THE CURIOUS CASE OF LOMITAPIDE

  • Shariq Naeem Syed Department of Clinical Pharmacology, Maulana Azad Medical College, New Delhi (INDIA) 110002
  • Vandana Roy Department of Clinical Pharmacology, Maulana Azad Medical College, New Delhi (INDIA) 110002
  • Piyush Misra Department of Clinical Pharmacology, Maulana Azad Medical College, New Delhi (INDIA) 110002
  • Akhil Dahiya Department of Clinical Pharmacology, Maulana Azad Medical College, New Delhi (INDIA) 110002

Abstract

Lomitapide is a new Microsomal transfer protein inhibitor. It has been approved as an orphan drug for treating homozygous familial hypercholetelemia. The drug went through various see-saw phases in its brief life. Understanding the life history of Lomitapide gives a unique opportunity to analyze diverse case scenarios during clinical trials and their rectification by using scientific methodology. 

Author Biographies

Shariq Naeem Syed, Department of Clinical Pharmacology, Maulana Azad Medical College, New Delhi (INDIA) 110002

Senior Resident Doctor, 

Department of Clinical Pharmacology

Vandana Roy, Department of Clinical Pharmacology, Maulana Azad Medical College, New Delhi (INDIA) 110002
Professor and Head of Department
Piyush Misra, Department of Clinical Pharmacology, Maulana Azad Medical College, New Delhi (INDIA) 110002
Senior Resident Doctor
Akhil Dahiya, Department of Clinical Pharmacology, Maulana Azad Medical College, New Delhi (INDIA) 110002
Junior Resident

References

1. Hussain MM, Shi J, Dreizen P. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res. 2003 Jan;44(1):22-32.
2. FDA approves new orphan drug for rare cholesterol disorder. FDA NEWS RELEASE (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm333285.htm, assessed on 1st May 2014)
3. Paracelsus. Toxipedia (http://www.toxipedia.org/display/toxipedia/Paracelsus, Accessed on 1st September 2014)
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How to Cite
Syed, S. N., V. Roy, P. Misra, and A. Dahiya. “THE CURIOUS CASE OF LOMITAPIDE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 1, Jan. 2015, p. 69, https://innovareacademics.in/journals/index.php/ajpcr/article/view/3705.
Section
Letter to Editor