• S SUNDAR Department of Biotechnology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India.




Bacterial resistance, Cefadroxil, Cephalexin, Agar disk diffusion


Objective: This study was aimed to overcome the problems of bacterial resistance to antibiotics used for the treatment of diseases.

Methods: In this aspect, two antibiotics were selected such as cefadroxil and cephalexin for the evaluation of antibiotic resistance against selected three Gram-positive microorganisms such as Bacillus subtilis, Staphylococcus aureus, and Bacillus cereus and three Gram-negative microorganisms such as E. coli, Pseudomonas aeruginosa, and Serratia marcescens. The selected antibiotics were evaluated by the determination of minimum inhibitory concentration and the agar disk diffusion method.

Results: According to the results obtained, cefadroxil was resistant against Bacillus cereus (25.6 μg/ml, 10 mm) and Serratia marcescens (25.6, 6 mm), sensitive against Pseudomonas aeruginosa (6.4 μg/ml, 18 mm), Bacillus subtilis (6.4 μg/ml, 30 mm), intermediate against E. coli (12.8 μg/ml, 16 mm), and Staphylococcus aureus (12.8 μg/ml, 15 mm). Similarly, cephalexin was resistant against Serratia marcescens (25.6 μg/ml, 10 mm), intermediate against E. coli (12.8 μg/ml, 14 mm), Pseudomonas aeruginosa (25.6 μg/ml, 14 mm), Bacillus subtilis (12.8 μg/ml, 15 mm), Staphylococcus aureus (6.4 μg/ml, 16 mm), and sensitive against Bacillus cereus (6.4 μg/ml, 18 mm) according to the CLSI report.

Conclusion: The increased illness of human beings by the usage of antibiotics frequently without prescriptions is a serious problem that dramatically raises the cost of health-care worldwide. Hence, the study was useful and effective for the determination of antibiotic resistance of cephalexin and cefadroxil for the future treatment in more efficacies with fewer side effects.


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How to Cite

SUNDAR, S. “EVALUATION OF BACTERIAL RESISTANCE OF CEFADROXIL, CEPHALEXIN AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE MICRO-ORGANISMS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 5, May 2022, pp. 54-57, doi:10.22159/ajpcr.2022.v15i5.37319.



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