IN VITRO ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF PYRENACANTHA VOLUBILIS (EEPV)

ANJALI P; VIMALAVATHINI R; KAVIMANI S

doi:10.22159/ajpcr.2020.v13i8.38017

ANJALI P Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry, India.
VIMALAVATHINI R Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry, India.
KAVIMANI S Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry, India.

DOI https://doi.org/10.22159/ajpcr.2020.v13i8.38017

Abstract

Objectives: The study was undertaken to evaluate the in vitro anti-inflammatory and anti-arthritic activity of the ethanolic extract of leaves of Pyrenacantha volubilis (EEPV) using human red blood cells (HRBCs) membrane stabilization and protein denaturation methods.

Methods: In the present study, the in vitro anti-inflammatory and anti-arthritic activity of EEPV was carried out using HRBC membrane stabilization by hypotonicity-induced hemolysis and protein denaturation using egg albumin methods at various concentrations (100, 200, 400, 800, and 1000) of EEPV. Diclofenac sodium was used as reference standard.

Results: P. volubilis was effective in inhibiting HRBC membrane stabilization and protein denaturation in a dose-dependent manner and was comparable to the standard drug diclofenac sodium.

Conclusion: The study suggests that P. volubilis has potential anti-inflammatory and anti-arthritic activity.

Keywords: Pyrenacantha volubilis, Anti-inflammatory, Anti-arthritic activity

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