VARIATIONS IN HEMATOLOGICAL PROFILE DURING DIFFERENT TRIMESTERS OF PREGNANCY
Objectives: The present study was aimed to determine the hematological parameters in pregnant women during different trimesters.
Methods: This is the case–control study, conducted to assess and compare the hematological profile among 120 pregnant (each trimester n=40) and 40 non-pregnant women attending the obstetrics and gynecology department, Santosh Medical College and Hospital, National Capital Region Delhi. SPSS software 17.0 was used for data statistical analysis. Unpaired Student’s t-test used to compare various hematological parameters between different trimesters of pregnancy and non-pregnant females. It is considered that p<0.05 is statistically significant. Analysis of variance with a post hoc test was used.
Results: It has been observed in this study that significant differences found in parameters such as systolic blood pressure (SBP), pulse pressure (PP), heart rate, white blood cell (WBC), hematocrit (HCT), Hb%, mean corpuscular volume (MCV), mean corpuscular hemoglobin (Hb) (MCH), and MCH concentration (MCHC). Significant differences in mean hematological values in between the trimesters (p<0.05): 1st trimester (WBC, HB, and HCT), 2nd trimester (SBP, diastolic blood pressure [DBP], PP, WBC, HB, HCT, and MCHC), and 3rd trimester (SBP, DBP, PP, WBC, HB, HCT, MCV, MCH, and MCHC) were seen, but no significant difference in age and erythrocytes count.
Conclusion: A considerable change in some hematological values between different trimesters evaluated, also decreased Hb, HCT values, and increased leukocyte values observed in the present study. These changes suggesting that it is very important to follow up hematological parameters of pregnant females during all trimesters of pregnancy so that any late complications can be avoided.
2. Banhidy F, Acs N, Puho EH, Czeizel AE. Iron deficiency anemia: Pregnancy outcomes with or without iron supplementation. Nutrition 2011;27:65-72.
3. Shaw J, Dey SK, Critchley HO, Horne AW. Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update 2010;16:432-44.
4. Das SC, Debasish S, Sanjay S, Tushar K, Biswas S. Study of hematological parameters in pregnancy. IOSR J Dent Med Sci 2013;12:42-4.
5. Ajzenberg N, Dreyfus M, Kaplan C, Yvart J, Weill B, Tchernia G. Pregnancy-associated thrombocytopenia revisited: Assessment and follow-up of 50 cases. Blood 1998;92:4573-80.
6. Barriga C, Rodriguez AB, Orega E. Increased phagocytic activity of polymorphonuclear leucocytes during pregnancy. Eur J Obstet Gynecol Reprod Biol 1994;57:43-6.
7. Technical Working Group on Prevention and Treatment of Severe Anaemia in Pregnancy. World Health Organization. Maternal Health and Safe Motherhood Programme. Prevention and Management of Severe Anaemia in Pregnancy : Report of a Technical Working Group, Geneva, 20-22 May 1991. Geneva, Switzerland: Technical Working Group on Prevention and Treatment of Severe Anaemia in Pregnancy; 1993.
8. Fleming AF. Hematological changes in pregnancy. Clin Obstet Gynecol 1975;2:269-83.
9. Shehlata N, Burrows RF, Kelton JG. Gestational thrombocytopenia. Clin Obstet Gynecol 1999;42:327-34.
10. Nathan HL, Duhig K, Hezelgrave NL, Chappell LC, Shennan AH. Blood pressure measurement in pregnancy. Obstet Gynaecol 2015;17:91-8.
11. Finkelstein I, Bgeginski R, Tartaruga MP, Alberton CL, Kruel LF. Heart rate and blood pressure behavior throughout pregnancy, with training in water medium. Rev Bras Med Esporte 2006;12:376-80.
12. Barrilleaux PS, Martin JN Jr. Hypertension therapy during pregnancy. Clin Obstet Gynecol 2002;45:22-34.
13. Wolfe LA, Davies GA, School of Physical and Health Education, Department of Obstetrics and Gynaecology and Physiology, Queen’s University, Kingston, Ontario, Canada. Canadian guidelines for exercise in pregnancy. Clin Obstet Gynecol 2003;46:488-95.
14. Ullah MZ, Khan MI, Shah M. Prevalence of anemia in pregnant women in district Karak, Khyber Pakhtunkhwa, Pakistan. Int J Biosci 2013;3:1-7.
15. James TR, Reid HL, Mullings AM. Are published standards for haematological indices in pregnancy applicable across populations: An evaluation in healthy pregnant Jamaican women. BMC Pregnancy Childbirth 2008;8:8.
16. Chandra S, Tripathi AK, Vaish K. Physiological changes in hematological parameter during pregnancy. Indian J Hematol Blood Transfus 2012;28:144-6.
17. Pughikumo OC, Pughikumo DT, Omunakwe HE. White blood cell counts in pregenant women in port Harcourt, Nigeria. IOSR J Dent Med Sci 2015;14:1-3.
18. Costantine MM. Physiologic and pharmacokinetic changes in pregnancy. Front Pharmacol J 2014;5:65.
19. Luppi P. How immune mechanisms are affected by pregnancy. Vaccine 2003;21:3352-7.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.