PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT PROPERTIES OF LEAF EXTRACTS OF CARICA PAPAYA
Objective: The objective of the present study aimed at investigating the phytochemical and antioxidant properties of Carica papaya leaf extracts.
Methods: As phytochemicals are biologically active compounds and a powerful group of plant chemicals, believed to stimulate the immune system along with antioxidants, the molecules which hinder oxidation of other molecules by the process of inhibiting or by generating the oxidizing chain reactions and preventing diseases. The total phenolic content (TPC) was determined by Folin-Ciocalteu method and total flavonoid contents (TFC) were determined aluminum chloride method and antioxidant by 2,2,1-diphenyl-1-picrylhydrazyl method.
Results: The results of phytochemical screening revealed the presence of bioactive compounds such as alkaloid, carbohydrates, and amino acids and TPC and TFC varied among the different solvent extracts, in which methanolic extracts showed highest amount of phytochemicals and TPC and TFC and antioxidants compared to other solvents.
Conclusion: The isolation and purification of specific bioactive compound may account as natural and promising medicines in exploration of new drug.
2. Samatha T, Shyamsundarachary R, Srinivas P, Swamy NR. Quantification of total phenolic and total flavonoid contents in extracts of Oroxylum indicum L. Kurz. Asian J Pharm Clin Res 2012;5:177-9.
3. Krishna KL, Paridhavi M, Patel JA. Review on nutritional, medicinal and pharmacological properties of Papaya (Carica papaya Linn.). Nat Prod Radiance 2008;7:364-73.
4. Abd Elgadir M, Salama M, Adam A. Carica papaya as a source of natural medicine and its utilization in selected pharmaceutical applications. Int J Pharm Sci 2014;6:880-4.
5. Parle M, Gurditta A, Basketful benefits of papaya. Int Res J Pharm 2011;2:6-12.
6. Ayoola PB, Adeyeye A. Phytochemical and nutrient evaluation of Carica papaya (Pawpaw) leaves. Int J Recent Res Appl Stud 2010;5:325-8.
7. Basalingappa KM, Anitha B, Raghu N, Gopenath TS, Karthikeyan M,Gnanasekaran A, et al. Medicinal uses of Carica papaya. J Nat Ayurvedic Med 2018;2:000144.
8. Meenakshi S, Umayaparvathi S, Arumugam M, Balasubramanian T. In vitro antioxidant properties of FTIR analysis of two sea weeds of Gulf of Mannar. Asian Pac J Trop Biomed 2011;1:S66-70.
9. Jaiswal P, Kumar P, Singh VK, Singh DK. Carica papaya Linn: A potential source for various health problems. J Pharm Res 2010;3:998- 1003.
10. Wu YY, Li W, Xu Y, Jin EH, Tu YY. Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analyses. J Zhejiang Univ Sci B 2011;12:744-51.
11. Ghosal M, Mandal PA. Phytochemical screening and antioxidant activities of two selected “bihi” fruits used as vegetables in Darjeeling Himalaya. Int J Pharm Pharm Sci 2012;4:567-74.
12. Nounagnon MS, Dah-Nouvlessounon D, Ntcha C, Legba B, Baba- Moussa F, Adjanohoun A, et al. Phytochemistry and biological activities of Crateva adansonii extracts. Int J Pharm Pharm Sci 2018;10:62-7.
13. Soni A, Sosa S. Phytochemical analysis and free radical scavenging potential of herbal and medicinal plant extracts. J Pharmacogn Phytochem 2013;2:22-9.
14. Ebrahimzadeh MA, Hosseinimehr SJ, Hamidinia A. Antioxidant and free radical scavenging activity of Feijoa sallowiana fruits peel and leaves. Pharmacologyonline 2008;1:7-14.
15. Rupeshkumar M, Kavitha K, Haldar PK. Role of herbal plants in the diabetes mellitus therapy: An overview. Int J Appl Pharm 2014;6:1-3.
16. Ainsworth EA, Gillespie KM. Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin-Ciocalteu reagent. Nat Protoc 2007;2:875-7.
17. Nandini G, Basalingappa KM. A review on significance of Carica papaya Linn: A promising medicinal plant. Int J Recent Sci Res 2019;11:37602-7.
18. Verma H, Prasad SB, Yashwant SH. Herbal drug delivery system: A modern era prospective. Int J Curr Pharm Rev Res 2013;4:88-101.
19. Pooja G Singh, Basalingappa KM. In vitro antioxidant, anti-inflammatory and anti-microbial activity of Carica papaya seeds. Glob J Med Res 2020;20:1-21.
20. Maisarah AM, Amira BN, Asmah R, Fauziah O. Antioxidant analysis of different parts of Carica papaya. Int Food Res J 2013;20:1043-8.
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