• Biswajit Biswal
  • Hardik Parmar
  • Jyotiranjan Nayak



Objective: Nicorandil is a vasodilatory drug used to treat angina. Nicorandil has oral bioavailability (70%) and half-life 1 hr. It is administered through
the buccal mucosa enters directly in the systemic circulation, thereby minimizing the first pass hepatic metabolism and adverse gastro-intestinal
effects. Therefore, the present investigation is concerned with the development of the buccal tablets.
Methods: The present work was performed to develop and evaluate buccal tablet containing anti-diabetic drug (nicorandil). Ethyl cellulose was used
as backing membrane and carbopol 934p and hydroxypropyl methyl cellulose K100M was used as bucco adhesive polymer. Aspartame was used as a
sweetener. Thickness, hardness, weight variation and drug uniformity were investigated.
Results: The tablet formulations were also subjected to drug release in 250 ml 6.8 phosphate buffer. Ex vivo bioadhesion, retention time and
permeation through porcine buccal mucosa membrane. F5 formulations showed maximum amounts of drugs release (89.24%) at the end of 10 hrs
dissolution study. F5 also showed maximum bioadhesion (0.0791 N) and the resident time of F5 formulation was 9.5 hrs. It shows 49.32% drug
release after 10 hrs permeation study through porcine buccal mucosa mounted in Franz cell.
Conclusion: The results of the study suggested that new buccal tablet formulations of combined bucco adhesive polymers can be suitably developed
as an alternate to conventional dosage forms.

Keywords: Nicorandil, Buccal tablet, Ex vivo bioadhesion, Ex vivo permeation.


Harris D, Robinson JR. Drug delivery via the mucous membranes of the oral cavity. J Pharm Sci 1992;81(1):1-10.

Beckett AH, Hossie RD. Buccal absorption of drugs. In: Gillette JR, editor. Handbuch Der Experimentellen Pharmakologie. Vol. 28. Berline: Springer-Verlag; 1971. p. 57-64.

Sweetman SC. Martindale: The Complete Drug Reference. 35th ed. London: Pharmaceutical Press; 2007. p. 5432.

Chavhan S, Anantwar S, Derle D. Design and evaluation of once daily sustained release matrix tablets of nicorandil. Int J Pharm Pharm Sci 2011;3(2):13-8.5. Biswal B, Karna N, Bhavsar B. Formulation and evaluation of repaglinide buccal tablet: Ex vivo bioadhesion study and ex vivo permeability study. J Appl Pharm Sci 2014;4:096-103.

Patel M, Pandya N, Bhaskar VH. Preparation, characterization and in vitro evaluation of repaglinide binary solid dispersions with hydrophilic polymers. Int Drug Dev Res 2011;3:111-21.

Swamy PV, Kinagi MB, Biradar SS, Gada S, Shilpa H. Formulation design and evaluation of bilayer buccal tablets of granisetron hydrochloride. Indian J Pharm Educ Res 2011;45:242-7.

Thanda V, Firoz S, Yerram C, Vikram A, Divya SK, Murali KT. Design and characterisation sustained release matrix tablets of repaglinide using natural polymers. Int J Pharm 2012;2:73-83.

Sellappan V, Srinivas P. Formulation and in vitro evaluation of losartan potassium mucoadhesive buccal tablets. Asian J Pharm Clin Res 2013;6:125-30.

Velmurugan S, Deepika B, Nagaraju K, Sundar V. Formulation and in-vitro evaluation of buccal tablets of piroxicam. Int J Pharm Tech Res 2010;2:1958-68.

Desai KG, Kumar TM. Preparation and evaluation of a novel buccal adhesive systems. AAPS Pharm Sci Tech 2004;5:1-9.

Vaidya M, Manwar V, Mahajan M, Sakarkar M. Design and in vitro evaluation of mucoadhesive buccal tablets of terbutaline sulphate. Int J Pharm Tech Res 2009;1:588-97.

Jadhav KR, Pawar AY, Talele GS. Development of gastroretentive optimized once a day floating and/or bioadhesive tablet of alfuzosin. Asian J Pharm Clin Res 2013;6:225-30.

Nakamura F, Ohta R, Machida Y, Nagai T. In vitro and in vivo nasal mucoadhesion of water soluble polymers. Int J Pharm 1996;134:173‑81.

Velmurugan S, Srinivas P. Formulation and in vitro evaluation of losartan potassium mucoadhesive buccal tablets. Asian J Pharm Clin Res 2013;6:125-30.

Shirsand SB, Wadageri GV, Raju SA, Kolli G, Reddy V. Design and evaluation of mucoadhesive bilayer buccal tablets of nebivolol. RGUHS J Pharm Sci 2013;3:40-7.

Shanker G, Kumar CK, Gonugunta CS, Kumar BV, Veerareddy PR. Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets. AAPS PharmSciTech 2009;10(2):530‑9.



How to Cite

Biswal, B., H. Parmar, and J. Nayak. “DESIGN DEVELOPMENT AND EVALUATION OF BUCCAL TABLET CONTAINING NICORANDIL AS A MODEL DRUG”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 2, Mar. 2015, pp. 102-6,



Original Article(s)