EVALUATION OF ANXIOLYTIC POTENTIAL OF VARIOUS EXTRACTS OF TAMARINDUS INDICA FLOWERS

  • BALAKRISHNA VUYYALA GNITC-SCHOOL OF PHARMACY
  • SENTHIL KUMAR D Department of pharmacology, Annamalai University, Chidambaram, Tamil Nadu, India.
  • THAKKALAPALLY LAKSHMI LAKSHMI1

Abstract

Objective: The objective of this study was designed to gauge the antianxiety activity of varied extracts, namely, n-hexane, chloroform, ethyl acetate, and methanol of the flowers of Tamarindus indica using elevated plus maze (EPM) model in albino mice.


Methods: Coarsely powdered tamarind was powdered and subjected to exhaustive Soxhlet extraction using n-hexane, chloroform, ethyl acetate, and methanol. Solvents were recovered from all extracts using a rotary vacuum evaporator under reduced pressure. Albino mice have ministered orally with different doses of the extracts (i.e., 200 and 400 mg/kg) and behavior was observed on the EPM. The standard (positive control) employed in the study Diazepam (2 mg/kg, P.O).


Results: Results indicate that the methanol extract of T. indica flowers showed maximum and significant dose-dependent effect at 200 and 400 mg/kg on EPM, the results were just like the standard antianxiety agent diazepam (2 mg/kg). Locomotor activity evaluated with two different doses of T. indica (200 and 400 mg/kg) using actophotometer. The results were shown to be decreased in a dose dependent model compared to control.


Conclusion: The methanol extract shows that the presence of polyphenols could be liable for the anxiolytic potential of T. indica. Hence, this plant could also be used as a useful antianxiety agent.

Keywords: Tamarind, Elevated plus maze, Diazepam, Anxiety

Author Biography

BALAKRISHNA VUYYALA, GNITC-SCHOOL OF PHARMACY
pharmacology

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VUYYALA, B., S. KUMAR D, and T. LAKSHMI. “EVALUATION OF ANXIOLYTIC POTENTIAL OF VARIOUS EXTRACTS OF TAMARINDUS INDICA FLOWERS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 11, Sept. 2020, pp. 136-8, doi:10.22159/ajpcr.2020.v13i11.39288.
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