• MOUNA BOUARFA Laboratory of Neuroendocrinology and Nutritional and Climatic Environment. Faculty of Sciences, Sidi Mohamed Ben Abdellah University, B.P. 1796, Atlas, Fez, Morocco.
  • ZOUHAIR SOUIRTI CHU Hassan II - Neurology - 30000 - Fez – Morocco.
  • PIERFRANCESCO CERRUTI 3Institute for Polymers, Composites and Biomaterials (IPCB-CNR), Naples, Italy.
  • MAURIZIO AVELLA Institute for Chemistry and Technology of Polymers (ICTP-CNR), Naples, Italy.
  • ABDELLAH FARAH Laboratory of Applied Organic Chemistry, Faculty of Sciences and Technology, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
  • DALILA BOUSTA Laboratory of Neuroendocrinology and Nutritional and Climatic Environment. Faculty of Sciences, Sidi Mohamed Ben Abdellah University, B.P. 1796, Atlas, Fez, Morocco.


Objective: The objective of the present study was to evaluate the anti-obesity activity of Cannabis sativa seed Flour (CSSF) on obese mice.

Methods: The experiment process was carried out in 8 weeks. In this time, three groups of animals were adopted: High caloric diet control group (HCD), group treated with 100 mg/kg of CSSF, group treated with 200 mg/kg of CSSF, and normal diet control group (ND). Then, the histopathological and biochemical parameters analysis has been realized at the end of the experiment.

Results: As a result, body weight gain, epididymal, and perirenal adipose tissue decreased in the CSSF (Cannabis sativa seed Flour) group in both doses (100 mg/kg and 200 mg/kg) compared to the HCD. CSSF lowered serum glucose level elevated by HCD. For lipid profiles, total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, and triglycerides (TG) significantly decreased in the CSSF group. The histopathological results of this study showed a regenerative effect of CSSF on the kidney and liver tissues.

Conclusion: It is concluded from the present study that CSSF can be used as a natural anti-obesity agent.

Keywords: Cannabis sativa seed flour, Anti-obesity, Mice, Kidney, Liver, Taounate, Kif, Khlalfa


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How to Cite
BOUARFA, M., Z. SOUIRTI, P. CERRUTI, M. AVELLA, A. FARAH, and D. BOUSTA. “ANTI-OBESITY EFFECT OF CANNABIS SATIVA SEED FLOUR FROM KHLALFA OF TAOUNATE REGION (NORTHERN OF MOROCCO) IN HIGH CALORIC DIET-INDUCED OBESE MICE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 11, Nov. 2020, pp. 139-44, doi:10.22159/ajpcr.2020.v13i11.39304.
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