INVESTIGATION OF ANALGESIC, ANTIOXIDANT, AND CYTOTOXIC PROPERTIES OF THE ETHANOLIC EXTRACT OF STREBLUS ASPER (ROOTS)

  • ANANTA KUMAR DAS Department of Pharmacy, Gono Bishwabidyalay, Mirzanagar, Savar, Dhaka.
  • ROZINA PARUL Department of Pharmacy, Gono Bishwabidyalay, Mirzanagar, Savar, Dhaka.
  • MD. MONIRUL ISLAM Department of Pharmacy, Gono Bishwabidyalay, Mirzanagar, Savar, Dhaka.
  • APU CHANDRA GHOSH Department of Pharmacy, Gono Bishwabidyalay, Mirzanagar, Savar, Dhaka.
  • MD. JAHIR ALAM Department of Pharmacy, Jahangirnagar University, Savar, Dhaka.

Abstract

Objective: This study evaluated the analgesic, antioxidant, and cytotoxic effects of ethanolic extract of Streblus asper roots.


Methods: Analgesic activities were carried out using paw licking and writhing tests. The extract was used at doses of 250 and 500 mg/kg per orally in Swiss albino mice of body weight 25–30 g. Antioxidant properties were investigated using 1, 1-diphenyl-1-picrylhydrazyl free-radical scavenging assay, total phenol content, total flavonoid content as well as reducing power capacity. The cytotoxic activity was determined by the Brine Shrimp lethality bioassay.


Results: The ethanolic extract of S. asper roots showed a significant effect in the formalin test (p<0.01). They also exhibit the highest analgesia (p<0.01) in the acetic acid-induced writhing model as well. The extract possessed antioxidant effects in all the models. It possessed a good cytotoxic activity.


Conclusion: The results suggested that S. asper root extract has a suitable analgesic, antioxidant effect as well as significant cytotoxic potential.

Keywords: Streblus asper, Analgesic, Antioxidant, Cytotoxicity, 1, 1-diphenyl-1-picrylhydrazyl free-radical scavenging assay

Author Biographies

APU CHANDRA GHOSH, Department of Pharmacy, Gono Bishwabidyalay, Mirzanagar, Savar, Dhaka.

Officer Production, Ziska Pharma. Ltd.  

MD. JAHIR ALAM, Department of Pharmacy, Jahangirnagar University, Savar, Dhaka.

M.Phil Student, Department of Pharmacy, Jahangirnagor University . 

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DAS, A. K., R. PARUL, M. M. ISLAM, A. C. GHOSH, and M. J. ALAM. “INVESTIGATION OF ANALGESIC, ANTIOXIDANT, AND CYTOTOXIC PROPERTIES OF THE ETHANOLIC EXTRACT OF STREBLUS ASPER (ROOTS)”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 14, no. 5, May 2021, pp. 126-31, doi:10.22159/ajpcr.2021.v14i5.39520.
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