VITAMIN D DEFICIENCY IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS

  • JINAN Q MOHAMMED Dermatology Unit in Basrah Teaching Hospital Basrah, Iraq.
  • ABDULSATAR J MATHKHOR Rheumatology Unit in Basrah Teaching Hospital Basrah, Iraq.
  • AMER S KHUDHAIRY Rheumatology Unit in Alfayhaa Teaching Hospital Basrah, Iraq.

Abstract

Objective: The objective of this study is to investigate the association between Vitamin D level and psoriasis, in particular in our city of the long, hot, and sunny weather, in an attempt to add a clarification to this controversial subject.


Methods: A case–control study included 120 patients with psoriasis and 38 patients with psoriatic arthritis (PsA); 89 (56.3%) patients were male. Psoriasis area and severity index (PASI) was calculated for all patients with psoriasis and disease activity score using 28 joints (DAS28) and erythrocyte sedimentation rate (DAS28) was measured for all patients with PsA. The control group comprised 164 age- and sex-matched participants (91 males and 73 females). Vitamin D serum level was performed for both patients and controls.


Results: Vitamin D levels in both patients and controls were 17.4±7.7 and 28.3±5.6, respectively. The level of Vitamin D was lower in a patient with disease duration equal and more than 10 years than those with a disease duration <10 years. There is no significant difference in Vitamin D levels between the two patient subgroups. Lower Vitamin D levels were associated with high PASI and high DAS28 in psoriasis and PsA, respectively.


Conclusion: Patients with psoriasis and PsA associated with low levels of serum Vitamin D. Vitamin D deficiency was found to be associated with long disease duration in both psoriasis and PsA. Patients with active disease have lower Vitamin D levels.

Keywords: Vitamin D, Psoriasis, Psoriatic arthritis, Psoriatic area, Disease severity index

References

1. Rasmussen GS, Maindal HT, Lomborg K. Self-management in daily life with psoriasis: An integrative review of patient needs for structured education. Nurs Res Pract 2012;2012:1-19.
2. Bardazzi F, Starace M, Bruni F, Magnano M, Piraccini BM, Alessandrini A. Nail psoriasis: An updated review and expert opinion on available treatments, including biologics. Acta Derm Venereol 2019;99:516-23.
3. Allayali A, Niaz G, Al Hawsawi K, Fatani M, Siddiqui I, Baghdadi R, et al. Association between Vitamin D deficiency and psoriasis: A case-control study. J Clin Exp Dermatol Res 2018;9:1000442.
4. Filoni A, Vestita M, Congedo M, Giudice G, Tafuri S, Bonamonte D. Association between psoriasis and Vitamin D: Duration of disease correlates with decreased Vitamin D serum levels: An observational case-control study. Medicine (Baltimore) 2018;97:10-3.
5. Keaney TC, Kirsner RS. New insights into the mechanism of narrow-band UVB therapy for psoriasis. J Invest Dermatol 2010;130:2534.
6. Dos M, Diniz S, Pinto JM, Marta M, Soares S. Serum levels of 25- oh Vitamin D in psoriatic patients and control subjects. JOJ Dermatol Cosmet 2019;1:65-8.
7. Sankowski AJ, ?ebkowska UM, ?wik?a J, Walecka I, Walecki J. Psoriatic arthritis. Polish J Radiol 2013;78:7-17.
8. Hallak A, Malhis M, Abajy MY. Vitamin-D deficiency and risk of acute coronary syndrome. Int J Pharm Pharm Sci 2018;10:171.
9. Soleymani T, Hung T, Soung J. The role of Vitamin D in psoriasis: A review. Int J Dermatol 2015;54:383-92.
10. Rendon A, Schäkel K. Psoriasis pathogenesis and treatment. Int J Mol Sci 2019;20:1-28.
11. Vestita M, Filoni A, Congedo M, Foti C, Bonamonte D. Vitamin D and atopic dermatitis in childhood. J Immunol Res 2015;2015:257879.
12. Solak B, Dikicier BS, Celik HD, Erdem T. Bone mineral density, 25-OH Vitamin D and inflammation in patients with psoriasis. Photodermatol Photoimmunol Photomed 2016;32:153-60.
13. Beata BC, Ligia BW. Serum Vitamin D level-the effect on the clinical course of psoriasis. Postep Dermatol Alergol 2016;33:445-9.
14. García de Tena J, Abejón L, Horcajo P. Vitamin D insufficiency. N Engl J Med 2011;364:248-54.
15. Kamangar F, Koo J, Heller M, Lee E, Bhutani T. Oral Vitamin D, still a viable treatment option for psoriasis. J Dermatol Treat 2013;24:261-7.
16. Taylor W, Gladman D, Helliwell P, Marchesoni A, Mease P, Mielants H. Classification criteria for psoriatic arthritis: Development of new criteria from a large international study. Arthritis Rheum 2006;54:2665-73.
17. Feldman SR, Krueger GG. Psoriasis assessment tools in clinical trials. Ann Rheum Dis 2005;64:65-8.
18. Salaffi F, Ciapetti A, Carotti M, Gasparini S, Gutierrez M. Disease activity in psoriatic arthritis: Comparison of the discriminative capacity and construct validity of six composite indices in a real world. Biomed Res Int 2014;2014:528105.
19. Mattozzi C, Paolino G, Richetta AG, Calvieri S. Psoriasis, Vitamin D and the importance of the cutaneous barrier’s integrity: An update. J Dermatol 2016;43:507-14.
20. Mostafa WZ, Hegazy RA. Vitamin D and the skin: Focus on a complex relationship: A review. J Adv Res 2013;6:793-804.
21. Gisondi P, Rossini M, Di Cesare A, Idolazzi L, Farina S, Beltrami G, et al. Vitamin D status in patients with chronic plaque psoriasis. Br J Dermatol 2012;166:505-10.
22. Orgaz-Molina J, Buendía-Eisman A, Arrabal-Polo MA, Ruiz JC, Arias-Santiago S. Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: A case-control study. J Am Acad Dermatol 2012;67:931-8.
23. Chandrashekar L, Kumari GR, Rajappa M, Revathy G, Munisamy M, Thappa DM. 25-hydroxy Vitamin D and ischaemia-modified albumin levels in psoriasis and their association with disease severity. Br J Biomed Sci 2015;72:56-60.
24. My?liwiec H, Kiluk P, ?elazowska-Rutkowska B, Baran A, Milewska AJ, My?liwiec P, et al. Vitamin D deficiency in psoriatic patients in North-East of Poland. Przegl Lek 2016;73:610-4.
25. Mattozzi C, Paolino G, Salvi M, Macaluso L, Scarnò M, De Vita G, et al. Correlation between plasmatic levels of Vitamin D and PASI score. G Ital Dermatol Venereol 2018;153:155-60.
26. Ibrahim A, Ltamimy H, Rayan M, Abdul-Hamied H. Measurement of Vitamin D and Its relation to psoriatic arthritis. Al Azhar Assiut Med J 2013;11:292-304.
27. Touma Z, Eder L, Zisman D, Feld J, Chandran V, Rosen CF, et al. Seasonal variation in Vitamin D levels in psoriatic arthritis patients from different latitudes and its association with clinical outcomes. Arthritis Care Res 2011;63:1440-7.
28. Bertrand KA, Giovannucci E, Liu Y, Malspeis S, Eliassen AH, Wu K, et al. Determinants of plasma 25-hydroxyvitamin D and development of prediction models in three US cohorts. Br J Nutr 2012;108:1889-96.
29. Cai Y, Fleming C, Yan J. New insights of T cells in the pathogenesis of psoriasis. Cell Mol Immunol 2012;9:302-9.
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Q MOHAMMED, J., A. J. MATHKHOR, and A. S KHUDHAIRY. “VITAMIN D DEFICIENCY IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 13, no. 11, Oct. 2020, pp. 168-70, doi:10.22159/ajpcr.2020.v13i11.39653.
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