EVALUATION OF EFFECT OF AQUEOUS EXTRACT OF ZINGIBER OFFICINALE ROSCOE (GINGER) ON ACUTE AND CHRONIC INFLAMMATION IN ADULT ALBINO RATS


Nagaraj B Malipatil, Manjunath S, Shruthi Dp

Abstract


 

Objective: Zingiber officinale (ZO) Roscoe (Ginger) is known to have many medicinal properties. The present study was carried out to evaluate the
anti-inflammatory activity of aqueous extract of ginger in adult albino rats, both in acute and chronic inflammatory settings and to compare the same
with standard anti-inflammatory agent diclofenac sodium.
Methods: Anti-inflammatory activity of ginger at the dose of 500 mg/kg body weight administered orally was evaluated in adult albino rats divided
into different groups as control, test and standard. Effect of ginger on acute inflammation was evaluated by carrageenan in induced rat paw edema
method and chronic inflammation was evaluated by rexin pellet granuloma method. Histopathological analysis was also done to evaluate effect of
ginger on leukocyte migration and lymphocyte accumulation at the site of acute and chronic inflammation respectively.
Results: Aqueous extract of ginger decreased the signs of both acute and chronic inflammation. The percent inhibition of edema (for acute
inflammation) with ZO extract was 28.80%, whereas with diclofenac sodium 63.46%. Percentage inhibition of granulation tissue (for chronic
inflammation) for ginger was 31.04% and 63.42% for diclofenac sodium.
Conclusion: Aqueous extract of ginger decreased the signs of both acute and chronic inflammation and was comparable to standard anti-inflammatory
drug diclofenac sodium. As currently available anti-inflammatory drugs are associated with number of side-effects, ginger can be potentially explored
as an anti-inflammatory agent with minimal or no side-effects.

Keywords: Zingiber officinale Roscoe, Ginger, Acute inflammation, Chronic inflammation, Rat paw oedema, Rexin pellet granuloma, Diclofenac sodium.


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About this article

Title

EVALUATION OF EFFECT OF AQUEOUS EXTRACT OF ZINGIBER OFFICINALE ROSCOE (GINGER) ON ACUTE AND CHRONIC INFLAMMATION IN ADULT ALBINO RATS

Date

01-03-2015

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 8 Issue 2 (March - April) 2015 Page: 113-116

Print ISSN

0974-2441

Online ISSN

2455-3891

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259 Views | 476 Downloads

Authors & Affiliations

Nagaraj B Malipatil
Private Practice
India

Manjunath S

Shruthi Dp


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