• JINISH JOSE Department of Pharmacology, Government Medical College, Kottayam, Kerala, India.
  • KALA KESAVAN P Department of Pharmacology, Government T. D. Medical College Alappuzha, Kerala, India.




Asparagus racemosus root, Soxhlet extraction, Anti-oxytocic property, Partial agonist


Objective: The objective of the study was to evaluate the anti-oxytocic activity of ethanolic extract of Asparagus racemosus root.

Methods: Ethanolic extract of A. racemosus root was taken by Soxhlet extraction method. Wistar strain albino non-pregnant female rats of weight 200–300 g were pre-treated with estrogen and were sacrificed to take their uterus. The tissue was then mounted in an organ bath containing de Jalon’s solution. The response of the tissue to various doses of oxytocin alone and then on adding increasing doses of the alcoholic extracts of A. racemosus along with the dose of oxytocin which produces sub-maximal contraction were recorded on a smoked drum.

Results: Extract in doses up to 40 mg when given along with oxytocin 0.1 unit produced graded increase in contractions in rat uterus. From 80 mg onward graded blockade of contractions occurred with complete blockade at 200 mg. On complete removal of the extract by thorough washing, it was seen that oxytocin was again able to produce contractions of the rat uterus tissue.

Conclusion: The ethanolic extract of A. racemosus root had demonstrated good anti-oxytocic property.


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Author Biography

KALA KESAVAN P, Department of Pharmacology, Government T. D. Medical College Alappuzha, Kerala, India.

Professor and Head

Department of Pharmacology

Government Medical College




Villamil PA, Burbano AC, Ospina LP, Palacios JA, Aguirre OE. Determination of antimicrobial activity in leaves and flowers of Chromolaena scabra (L.F) R.M King and H. Rob. Asian J Pharm Clin Res 2020;13:53-6.

Pruthvi ML, Mahesh MK, Rohini SM. Efficacy of Euphorbia heterophylla latex against pathogenic bacteria and fungi. Asian J Pharm Clin Res 2020;13:141-5.

Dimple, Kumar A, Kumar V, Tomer V. Traditional medicinal systems for treatment of diabetes mellitus: A review. Int J Pharm Pharm Sci 2018;10:7-17.

Raval PK, Nishteshwar K, Patel BR, Shukla VJ. Asparagus racemosus Willd. A comparative phytochemical analysis of fresh dried roots of Shatavari. Int J Pharm Bio Arch 2012;3:1458-61.

Jose J, Devassykutty D. Evaluation of antibacterial activity of Asparagus racemosus in urinary tract infection. Natl J Physiol Pharm Pharmacol 2016;6:596-8.

Nadkarni KM, Nadkarni AK. Dr. K.M. Nadkarni’s Indian Materia Medica with Ayurvedic, Unani-Tibbi, Siddha, Allopathic, Homeopathic, Naturopathic and Home Remedies, Appendicces and Indexes. 3rd ed. Bombay: Popular Prakashan; 1976. p. 151-5.

Roy S, Pradhan S, Mandal S, Das K, Patra A, Samanta A, et al. Phytochemical analysis, antimicrobial activity and assessment of potential compounds by thin layer chromatography of ethanol fraction of Asparagus racemosus roots. Int J Pharm Sci 2014;6:367-70.

Foong SC, Tan ML, Foong WC, Marasco LA, Ho JJ, Ong JH. Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants. Cochrane Database Syst Rev 2020;5:CD011505.

Choudhary D, Sharma D. A phytopharmacological review on Asparagus racemosus. Int J Sci Res 2014;3:742-6.

Drugs and Lactation Database (LactMed). Bethesda, MD: National Library of Medicine; 2006.

Ritter J, Flower R, Henderson G, Loke YK, MacEwan D, Rang H. Rang And Dale’s Pharmacology. 9th ed. Edinburgh: Elsevier; 2019.

Lund LR, Rømer J, Thomasset N, Solberg H, Pyke C, Bissell MJ, et al. Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and dependent pathways. Development 1996;122:181-93.

Uvnäs-Moberg K, Eriksson M. Breastfeeding: Physiological, endocrine and behavioral adaptations caused by oxytocin and local neurogenic activity in the nipple and mammary gland. Acta Paediatr 1996;85:525-30.

Prevost M, Zelkowitz P, Tulandi T, Hayton B, Feeley N, Carter CS, et al. Oxytocin in pregnancy and the postpartum: relations to labor and its management. Front Public Health 2014;2:1.

Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z. The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents. Int J Endocrinol 2011;2011:350546.



How to Cite

JINISH JOSE, and KALA KESAVAN P. “EVALUATION OF ANTI-OXYTOCIC ACTIVITY OF ASPARAGUS RACEMOSUS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 14, no. 3, Mar. 2021, pp. 103-5, doi:10.22159/ajpcr.2021.v14i3.39726.



Original Article(s)