• LONG HOANG NGO VK-Tech Center, Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City.
  • THI HAI YEN NGUYEN Faculty of Science, Dong Nai University, Bien Hoa City.
  • VU KHAC TRAN Department of Pharmaceutical Chemistry and Pesticides Technology, School of Chemical Engineering, Hanoi University of Science and Technology.
  • VU VAN DOAN Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
  • MINH VAN NGUYEN Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, Jeollabuk-do, Korea.
  • HIEU TRUNG BUI VK-Tech Center, Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City.


Objectives: Infectious diseases caused by bacteria are a leading cause of death worldwide. Hence, the objectives of the study are aimed to evaluate the antibacterial activity against five human pathogenic bacteria of methanolic extracts from 66 plants collected from Vietnam.

Methods: The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of methanol extracts of 66 plant species against five bacterial strains.

Results: In this study, all the plant extracts were active against at least one train with MIC values ranging from 24 to 2048 μg/mL. Twenty-five plant extracts were active against all three Gram-positive bacteria (Bacillus cereus, Bacillus subtilis, and Staphylococcus aureus). Of these, the extracts of Macaranga trichocarpa (Rchb. f. and Zoll.) Mull. Arg. (Euphorbiaceae), Calophyllum inophyllum L. (Clusiaceae) and Caryodaphnopsis baviensis (Lecomte) Airy Shaw (Lauraceae) exhibited the highest antibacterial activity (MIC =24–128 μg/mL), followed by extracts of Betula alnoides Buch.- Ham. e × . D. Don (Betulaceae), Acronychia pedunculata (L.) Miq. (Rutaceae), Croton alpinus A. Chev. ex Gagnep. (Euphorbiaceae) (MIC =64–256 μg/mL). Furthermore, the extract of Rhus chinensis Mill. (Anacardiaceae) and Annona reticulata L. (Annonaceae) exhibited potent antibacterial activity against the two Bacillus species (MIC =32–64 μg/mL).

Conclusion: Results of this study reveal that plant extracts from Vietnam have highly antibacterial activity against Gram-positive bacteria. These results suggest that Vietnamese plant extracts may be a rich source of antibacterial drugs.

Keywords: Screening, Antibacterial, Human pathogenic bacteria, Vietnamese plant extracts


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How to Cite
NGO, L. H., T. H. Y. NGUYEN, V. K. TRAN, V. V. DOAN, M. V. NGUYEN, and H. T. BUI. “SCREENING ANTIBACTERIAL ACTIVITY OF VIETNAMESE PLANT EXTRACTS AGAINST HUMAN PATHOGENIC BACTERIA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 14, no. 6, Apr. 2021, pp. 62-65, doi:10.22159/ajpcr.2021.v14i6.39790.
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