STEVENS-JOHNSON SYNDROME DUE TO ADVERSE DRUG REACTIONS: A CASE SERIES

ZAFAR MASOOD ANSARI; BHAVANA SRIVASTAVA; ARUNIMA ROHATGI; KALPANA JOSHI

doi:10.22159/ajpcr.2021.v14i2.40089

Authors

ZAFAR MASOOD ANSARI Department of Pharmacology, Government Medical College, Haldwani, Nainital, Uttarakhand, India.
BHAVANA SRIVASTAVA Department of Pharmacology, Government Medical College, Haldwani, Nainital, Uttarakhand, India.
ARUNIMA ROHATGI Department of Pharmacology, Government Medical College, Haldwani, Nainital, Uttarakhand, India.
KALPANA JOSHI Department of Pharmacology, Government Medical College, Haldwani, Nainital, Uttarakhand, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i2.40089

Keywords:

Stevens-Johnson syndrome, Ofloxacin, Chloroquine, Blisters

Abstract

Stevens-Johnson syndrome (SJS) is a rare, serious disorder affecting skin and mucous membranes. It is one of the few serious dermatological adverse effects of drugs encountered in clinical practice which is characterized by blisters and rash on skin, mucous membranes, swelling over face and lips, and hyperpigmentation. After that, the outer layer of affected skin becomes dead, sheds, and starts to heal after several days of inflicting injury. Here, we present a case series of ofloxacin and chloroquine induced SJS after the consent given by patients. First case is a 62 years old male received Ofloxacin and second patient is a 40 years old male received chloroquine. Both patients experienced a severe skin reaction which was diagnosed as SJS. The above-mentioned medications will be implicated in cases of SJS. We should prescribe these medications with extreme caution.

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