URARIA PICTA (JACQ.): A REVIEW ON ETHNOMEDICAL USES, PHYTOCHEMISTRY, AND BIOLOGICAL ACTIVITIES
Uraria Picta (Jacq.): A Review
The aim of this systematic review is to provide an in-depth study of ethnological uses, phyto-chemistry, pharmacological activities, and toxicological research in Uraria picta (Jacq.), to identify remaining gaps, and to provide a basis for future research. By searching for the words “U. picta” and “Prishnaparni” in electronic databases such as SciFinder, Web of Science, PubMed, and Google Scholar, information on common uses, phytochemistry, and pharmacological activities was systematically collected. Phytochemical analysis of U. picta shows various components such as alkaloids, flavonoids, steroids, terpenoids, phenols, and saponins. The extracts and their isolated components showed numerous in vitro and in vivo pharmacological effects, including urinary tract diseases, tumors, edema, smoking, and dyspnea. On the other hand, searches of patent databases found almost seven applications, highlighting the differences between a large number of published scientific articles and non-existent patent applications. This event demonstrates the technological potential of undiscovered species. Ethnographic research shows that U. picta, an important Asian medicinal plant, is used to treat many diseases. In this review, the ethnobotanical, phytochemical, pharmacological, and ethnological properties of various morphological parts of the U. picta plant are highlighted. Future research has provided information for commercial research and has shown that this herb has tremendous potential for pharmaceutical and nutritional applications.
2. Hooker JD. The flora of British India. In: The Flora of British India. Vol. 1. ???: ???; 1872.
3. Kirtikar KR, Basu BD. Indian Medicinal Plants. Allahabad: Lalit Mohan Publication; 1935.
4. Yusuf M, Chowdhury JU, Wahab MA, Begum J. Medical Plants of Bangladesh. Dhaka: BCSIR Chittagong Laboratory; 1994. p. 73.
5. McNeill J. International code of botanical nomenclature. In: Seventeenth International Botanical Congress Vienna. Vol. 568. Austria: International Atomic Energy Agency; 2005.
6. Ohashi H, Iokawa Y. A revision of Uraria (Leguminosae) in Taiwan. Taiwania 2007;52:177-83.
7. Billore KV, Yelne MB, Dennis TJ, Chaudhari BG. Database on Medicinal Plants Used in Ayurveda. Vol. 6. New Delhi: Central Council for Research in Ayurveda and Siddha; 2004. p. 314-20.
8. Yadav AK, Yadav D, Shanker K, Verma RK, Saxena AK, Gupta MM. Flavone glycoside based validated RP-LC method for quality evaluation of Prishniparni (Uraria picta). Chromatographia 2009;69:653-8.
9. Pathak JM, Krishnamurthy R, Chandorkar MS, Gulkari VD. Gupta R identification of high yielding genotypes of Dashmool Shalparni (Desmodium gangeticum) drug plant and its cultivation under high density planting. Indian J Hortic 2005;62:378-84.
10. Saxena HO, Soni A, Mohammad N, Kakkar A, Singh N. HPLC analysis of rhoifolin in different plant parts of Uraria picta: A dashmool species. Indian J Trop Biodivers 2014;22:199-201.
11. Government of India. The Ayurvedic Formulary of India, Part I. India: Government of India; 2003. p. 55.
12. Sastry K. Caraka Samhita of Agnivesa with Cakrapanidatta Tika. Varanasi: Chaukhambha Sanskrit Sansthan; 1997.
13. Bhattacharya A, Datta AK. A report on genetic male sterility in Uraria picta (Jacq.) DC. Cytologia 2011;76:55-62.
14. Kale RH, Halde UK, Biyani KR. Protective effect of aqueous extract of Uraria picta on acetaminophen induced nephrotoxicity in rats. Int J Res Pharm Biomed Sci 2012;3:110-3.
15. Saxena HO, Mohan B, Kakkar A. Assessment of variation in Rhoifolin content in aerial parts of Uraria picta Desv. from different locations of Madhya Pradesh. J Pharm Res 2016;10:185-90.
16. Gurav AM, Dhanorkar VM, Dhar BP, Lavekar GS. In vitro propagation of the medicinal plant Uraria picta (Jacq.) Desv. ex DC. from cotyledonary node and nodal explants. Pharmacogn Mag 2008;4:S239-45.
17. Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. Berlin: Springer; 2007. p. 699-700.
18. Rahman MM, Gibbons S, Gray AI. Isoflavanones from Uraria picta and their antimicrobial activity. Phytochemistry 2007;68:1692-7.
19. Igboechi AC, Osazuwa EO, Igwe UE. Laboratory evaluation of the acaricidal properties of extracts from Uraria picta (Leguminosae). J Ethnopharmacol 1989;26:293-8.
20. Manonmani S, Vishwanathan VP, Subramanian S, Govindasamy S. Biochemical studies on the antiulcerogenic activity of cauvery 100, an ayurvedic formulation in experimental ulcers. Indian J Pharmacol 1995;27:101.
21. Occhiuto F, Limardi F. Comparative effects of the flavonoids luteolin, apiin and rhoifolin on experimental pulmonary hypertension in the dog. Phytother Res 1994;8:153-6.
22. Occhiuto F, Circosta C, de Pasquale A, Briguglio F. Comparative haemodynamic effects of the flavonoids rhoifolin and vitexin in the dog. Phytother Res 1990;4:118-20.
23. Singh NK. Anti-inflammatory and hepatoprotective activities of the roots of Uraria picta. Int J Green Pharm 2017;11:S116-73.
24. Rastogi C, Paswan SK, Verma P, Vishwakarma V, Srivastava S, Rao CV. Chapter-6 Uraria picta: A comprehensive review and its pharmacological action. Recent Adv Pharm Sci ???; ???:93.
25. Groom A. Uraria picta, in IUCN Red List of Threatened Species. International Union for Conservation of Nature and Natural Resources, IUCN; 2012.
26. Saxena HO, Soni A, Mohammad N, Choubey SK. Phytochemical screening and elemental analysis in different plant parts of Uraria picta Desv.: A dashmul species. J Chem Pharm Res 2014;6:756-60.
27. Committee AP. The Ayurvedic Pharmacopoeia of India, Part-I. New Delhi, India: Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy (AYUSH); 2004.
28. Parrotta JA. Healing Plants of Peninsular India. United Kingdom: CABI Publishing; 2001.
29. Ved DK, Goraya GS. Demand and supply of medicinal plants in India. Bangalore, New Delhi, India: FRLHT, NMPB; 2007. p. 18.
30. Xueqin M, Chengjian Z, Changling H, Khalid R, Luping Q. The genus desmodium (fabaceae)-traditional uses in Chinese medicine, phytochemistry and pharmacology. J Ethnopharmacol 2011;138: 314-32.
31. Naik K, Krishnamurthy R. Anti-inflammatory activity of methanolic extracts of Pseudarthria viscida and Uraria picta against carrageenan induced paw edema in albino rat. J Med Aromat Plants 2018;9:1.
32. Olufemi AO, Omoniyi YK, Akinyinka AA, Ibitayo AM. Mechanistic evaluation of toxicity, antinociceptive, antiinflammatory and antioxidant actions of leaf extract of Uraria picta. LASU J Med Sci 2016;1:1-10.
33. Ghildiyal S, Gautam MK, Joshi VK, Goel RK. Anti-inflammatory activity of two classical formulations of laghupanchamula in rats. J Ayurveda Integr Med 2013;4:23-7.
34. Arka G, Anindita K, Ankit S, Kumar SA, Kumar MS. Preliminary evaluation of hepatoprotective potential of the polyherbal formulation. J Intercult Ethnopharmacol 2015;4:118-24.
35. Kumar B, Prasad P, Mehdi J, Gupta A, Shanker K, Singh M, et al. Morpho-metric and molecular characterization of Uraria picta (Jacq.) Desv. ex DC.-a medicinal plant. J Appl Res Med Aromat Plants 2020; ???:100242.
36. Srilakshmi US, Raj GA. Standardizationo of dashamoola kwatha choorna: A herbal compound drug used for parisheka in spastic cerebral palsy. Int J Pharm Sci Res 2018;9:4937-40.
37. Osazuwa EO, Igboechi AC. Anti-microbial activity of a chemical isolate from the leaves of Uraria picta. Phytother Res 1988;2:204-6.
38. Laxman AM, Goga GS, Dayaram NT. Seed viability and influence of presowing treatments on germination and seedling development of Uraria picta (Jacq.) DC. Seed Sci Biotech 2009;3:48-53.
39. Amole OO, Mofomosara SH, Ekene OA. Evaluation of the antidiarrhoeal effect of Lannea welwitschii Hiern (Anacardiaceae) bark extract. Afr J Pharm Pharmacol 2010;4:151-7.
40. Agrawal K. Review of drugs under laghupanchmula. J Pharmacogn Phytochem 2018;7:3363-9.
41. Patel BD, Kamariya YH, Patel MB. Free radical scavenging potential of ethanolic extract of Uraria picta Linn. Pharmacologyonline 2011;2:134-45.
42. Mohan B, Saxena HO, Kakkar A, Mishra MK. Determination of antioxidant activity, total phenolic and flavonoid contents in leaves, stem and roots of Uraria picta Desv. Environ Conserv J 2019;20:1-8.
43. Patel BD, Kamariya YH, Patel MB. Antioxidant potential of aqueous extract of entire plant of Uraria picta Desv. J Int Pharm Res 2011;3:92-6.
44. Odubanjo VO, Oboh G, Ibukun EO. Antioxidant and anticholinesterase activities of aqueous extract of Uraria picta (Jacq.) DC. Afr J Pharm Pharmacol 2013;7:2768-73.
45. Bansal N, Parle M. Beneficial effect of chyawanprash on cognitive function in aged mice. Pharm Biol 2011;49:2-8.
46. Sonibare MA, Ayoola IO, Elufioye TO. Antioxidant and acetylcholinesterase inhibitory activities of leaf extract and fractions of Albizia adianthifolia (Schumach) WF Wright. J Basic Clin Physiol Pharmacol 2017;28:143-8.
47. Alias NZ, Idris MH, Somat NA, Mahmud N, Hasan S, Wai LK, et al. Synthesis, antioxidant, anticholinesterase activities and molecular docking studies of coumaryl 1, 3-selenazoles derivatives. Preprints 2020;1:1-10.
48. Prasad GU, Sankaran PS, Pande PJ. Studies on fracture healing by using radioactive P-32 and Ca-45 under the influence of Uraria picta. Indian J Med Res 1965;53:645-50.
49. Singla C, Drabu S, Verma R, Dhiman A, Sharma A. Recent update on proficient bone fracture revivifying herbs. Int Res J Pharm 2011;2:3-5.
50. Singh V. Medicinal plants and bone healing. Natl J Maxillofac Surg 2017;8:4-11.
51. Eldahshan OA. Rhoifolin; a potent antiproliferative effect on cancer cell lines. J Pharm Res Int 2013;3:46-53.
52. Al-Doaiss AA. Hepatotoxicity-induced by the therapeutic dose of acetaminophenand the ameliorative effect of oral co-administration of selenium/Tribulus terrestris extract in rats. Int J Morphol 2020;38:1444-54.
53. Hemlal H, Ravi S. GC-MS, HPTLC and antimicrobial analysis of root extracts of Pseudarthria viscida Wight and Arn and Desmodium gangeticum (Linn.) DC. Int Res J Biol Sci 2012;1:57-65.
54. Gaiuson WY, Solomon NE, Yaduma N, Samaila IM, Thagriki D. Preliminary evaluation of hepatorenal protective potentials of Kigelia africana Ethanolic leaf extract on carbon tetrachloride induced toxicity in adult male wistar rats. Am\ J Plant Sci 2020;11:1345.
55. Sivakrishnan S, Kottaimuthu A. Hepatoprotective activity of ethanolic extract of aerial parts of Albizia procera Roxb (Benth.) against paracetamol induced liver toxicity on wistar rats. Int J Pharm Pharm Sci 2014;6:233-8.
56. Fatokun FK, Danckwerts MP, Crowther N. Oral glucose tolerance of traditional medicines in a diabetes induced rat model. Int J Pharmacogn Phytochem Res 2012;4:41-8.
57. Ramaiah M, Amani P, Bhavitha S, Gayathri T, Lohitha T. A pharmacological and phytochemical based review on Uraria lagopodoides (L.) DC. J Integral Sci 2019;1:1-5.
58. Jayaprasad B, Thamayandhi D, Sharavanan PS. Traditionally using antidiabetic medicinal plants in Tamil Nadu. Int J Res Pharm Biosci 2012;2:1-8.
59. Gopalakrishnan G, Dhanapal CK. Evaluation of anti-diabetic activity of methanolic extract of Coleus vettiveroides Jacob in streptozotocin-induced diabetic rats. J Pharm Sci Res 2014;6:97.
60. Joshi PR, Patel BR. Pratinidhi dravya and its adaptation in current scenario-a birds eye view. Res Pharm 2012;1:1-5.
61. Garg N. Phytochemical studies and anti anxiey activity of Uraria Picta leaves. J Res Opin 2015;2:1-5.
62. Sarris J, McIntyre E, Camfield DA. Plant-based medicines for anxiety disorders, Part 1. CNS Drugs 2013;27:207-19.
63. De Sousa A. Herbal medicines and anxiety disorders: An overview. J Med Plants 2013;1:18-23.
64. Roy-Byrne PP, Bystritsky A, Russo J, Craske MG, Sherbourne CD, Stein MB. Use of herbal medicine in primary care patients with mood and anxiety disorders. Psychosomatics 2005;46:117-22.
65. Ernst E. Herbal remedies for anxiety-a systematic review of controlled clinical trials. Phytomedicine 2006;13:205-8.
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