SPLENIC PROTECTIVE EFFECT OF WHITE TURMERIC EXTRACT AGAINST COPPER TOXICITY IN MALE WISTAR RATS

  • LINDA CHIUMAN Department of , Faculty of Medicine, Universitas Prima Indonesia, North Sumatera, Indonesia.

Abstract

Objective: This study was aimed to investigate the protective effect of white turmeric against copper splenic toxicity in male Wistar rats.


Methods: This study used 30 rats divided into six groups: Negative groups, positive groups, Ethanol Extract of White Turmeric I-III. After 14 days, all rats were sacrificed by chloroform inhalation, and the spleen was excised and process to histopathology preparation and evaluation.


Results: The result of this study showed that white turmeric acutely protected spleen from the impact of copper by reducing congestion/vasodilatation of the blood vessel (p=0.002), neutrophil infiltration (p<0.05), and lymphoid necrosis (p<0.05). Nevertheless, white turmeric extract may induce chronic inflammation by increasing the number of macrophage cells (p=0.003).


Conclusion: Overall, it can be concluded that the white turmeric extracts acutely protect spleen from the impact of copper.

Keywords: Copper, Ethanol, Spleen, White turmeric

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CHIUMAN, L. “SPLENIC PROTECTIVE EFFECT OF WHITE TURMERIC EXTRACT AGAINST COPPER TOXICITY IN MALE WISTAR RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 14, no. 5, May 2021, pp. 66-69, doi:10.22159/ajpcr.2021.v14i5.40789.
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