FORMULATION AND CHARACTERIZATION OF SUSTAINED RELEASE TABLET USING MARDI GUM
Objective: The present research work was to develop and evaluate alprazolam sustained release tablet using Mardi gum, a comparative study on binding properties of gum and hydroxypropyl methylcellulose (HPMC) was performed.
Methods: Formulation of alprazolam tablets (f1–f6) was done by direct compression method using 15%, 30%, and 45% concentration of gum as a natural binder, and HPMC was used as synthetic matrix forming agent. Microcrystalline cellulose was used as diluents, talc, and magnesium stearate as a lubricant and PVP K30 as the binder. The formulated batches were evaluated for parameters such as tablet thickness, % friability, hardness, weight variation, and in vitro drug release characteristics. The release information was fitted into different dynamics models to decide the release mechanism of the drug.
Results: The results showed that all the parameters of the developed tablets (f1–f6) were in fulfillment with pharmacopeia limits. In vitro, drug release studies showed that formulation f1 had most controlled and sustained manner releaser with maximum drug release of 97.89±0.52% in 18 h with comparison to f2–f4 and f6 drug release is 98.12±0.55%, 97.24±0.57%, 98.16±0.74%, and 97.26±0.35%, respectively, in 16 h and f5 giving 97.89±0.85% release in 14 h.
Conclusion: On the basis of obtained result, it can be concluded that Mardi gum can be used to sustain the drug release as a natural polymer in tablet dosage form.
2. Niranjan P, Shanmugam S, Vetrichelvan T. Formulation and in-vitro evaluation of sustained release matrix tablets of ibuprofen. Res J Pharm Biol Chem Sci 2013;4:1656-64.
3. Alderman DA. A review of cellulose ethers in hydrophilic matrices for oral controlled release dosage forms. Int J Pharm 1984;5:1-9.
4. Yu L, Dean K, Li L. Polymer blends and composites from renewable resources. Prog Polym Sci 2006;31:576-602.
5. Kumare MM, Shendarkar GR. Isolation, purification and characterization of the gum exudates from Mardi (Terminalia tomentosa). Int J Pharm Bio Sci 2018;8:107-112.
6. Nandhini J, Rajalakshmi AN. Formulation development and evaluation of methylprednisolone dispersible tablets. Asian J Pharm Pharmacol 2018;4:514-21.
7. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. Vol. 24. Pune: Nirali Prakashan 2003.
8. Cooper J, Gunn G. Powder flow and compaction. In: Carter SJ, editor. Tutorial Pharmacy. New Delhi, India: CBS Publishers and Distributers; 1986. p. 211-33.
9. Shah D, Shah Y, Rampadhan M. Development and evaluation of controlled release diltiazem hydrochloride microparticles using cross-linked polymer (vinyl alcohol). Drug Dev Ind Pharm 1997;23:567-74.
10. Aulton ME, Well TI. Pharmaceutics. In: The Sciences of Dosage form Design. London, England: Churchill Livingstone; 1998.
11. Gunjal PT, Shinde MB, Gharge VS, Pimple SV, Gurjar MK, Shah MN. Design, development and optimization of S (-) atenolol floating sustained release matrix tablets using surface response methodology. Indian J Pharm Sci 2015;77:563-72.
12. Bharadwaj TR, Kanwar M, Lal R, Gupta A. Natural gums and modified natural gums as sustained-release carriers. Drug Dev Ind Pharm 2000;26:1025-38.
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