FORMULATION AND CHARACTERIZATION OF SUSTAINED RELEASE TABLET USING MARDI GUM

MANGESH M KUMARE; GIRIDHAR R SHENDARKAR

doi:10.22159/ajpcr.2021.v14i5.41138

Authors

MANGESH M KUMARE Department of Pharmacy, Smt. Kusumtai Wankhede Institute of Pharmacy, Katol, Maharashtra, India.
GIRIDHAR R SHENDARKAR Department of Pharmacy, Nanded Pharmacy College, Nanded, Maharashtra, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i5.41138

Keywords:

Alprazolam, Mardi gum, Matrix tablets, Natural polymer, Sustain

Abstract

Objective: The present research work was to develop and evaluate alprazolam sustained release tablet using Mardi gum, a comparative study on binding properties of gum and hydroxypropyl methylcellulose (HPMC) was performed.

Methods: Formulation of alprazolam tablets (f1–f6) was done by direct compression method using 15%, 30%, and 45% concentration of gum as a natural binder, and HPMC was used as synthetic matrix forming agent. Microcrystalline cellulose was used as diluents, talc, and magnesium stearate as a lubricant and PVP K30 as the binder. The formulated batches were evaluated for parameters such as tablet thickness, % friability, hardness, weight variation, and in vitro drug release characteristics. The release information was fitted into different dynamics models to decide the release mechanism of the drug.

Results: The results showed that all the parameters of the developed tablets (f1–f6) were in fulfillment with pharmacopeia limits. In vitro, drug release studies showed that formulation f1 had most controlled and sustained manner releaser with maximum drug release of 97.89±0.52% in 18 h with comparison to f2–f4 and f6 drug release is 98.12±0.55%, 97.24±0.57%, 98.16±0.74%, and 97.26±0.35%, respectively, in 16 h and f5 giving 97.89±0.85% release in 14 h.

Conclusion: On the basis of obtained result, it can be concluded that Mardi gum can be used to sustain the drug release as a natural polymer in tablet dosage form.

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