DESIGN, OPTIMIZATION, AND EVALUATION OF IBUPROFEN FAST-DISSOLVING TABLETS EMPLOYING STARCH VALERATE – A NOVEL SUPER DISINTEGRANT

  • ANTHOSH KUMAR RADA GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, India.
  • RAMYA M GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, India.
  • SHAMBHAVI KANDUKURI GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, India.

Abstract

Objective: The main aim is to design, optimize, and evaluate ibuprofen fast-dissolving tablets by employing starch valerate-A novel super disintegrant.


Methods: The fast-dissolving tablet of ibuprofen was prepared by employing starch valerate as super disintegrant in different proportions in each case by direct compression method using 23 factorial design, sodium starch glycolate, and crospovidone used as super disintegrants. In the 23 factorial design, these super disintegrants were applied to investigate the interaction effects of three variables, that is, (a) starch valerate, (b) sodium starch glycolate, and (c) crospovidone. The drug content, hardness, friability, disintegration time, and other dissolution characteristics were determined.


Results: The starch valerate prepared was found to be fine, free-flowing, slightly crystalline powder. Starch xanthate exhibited good swelling in water with 125.2%. All the fast-dissolving tablets formulated employing starch valerate were of good quality with regard to drug content (100±5%), hardness (3.6–3.8 kg/sq. cm), and friability (0.11-0.12%). The disintegration time of all the formulated tablets was found to be in the range of 12±0.02 to 30±0.02s. The optimized formulation FL8 has the least disintegration time, that is, 12±0. 02s. The in vitro wetting time of the formulated tablets was found to be in the range of 21±0.09 to 44±0.10s. The in-vitro wetting time was less (i.e., 90s) in optimized formulation FL8. The water absorption ratio of the formulated tablets was found to be in the range of 30±0.12 to 100±0.09%.


Conclusion: Starch valerate was found to be a super disintegrant which enhanced the dissolution efficiency when combined with sodium starch glycolate, crospovidone, with the ibuprofen.

Keywords: Fast dissolving, Super disintegrant, Starch valerate, Optimization

References

1. Bhavani PD, Rao NG. Formulation and evaluation of valsartan fast disintegrating tablets by vacuum drying technique. Asian J Pharm Clin Res 2016;9:73-9.
2. Kumar S, Garg SK. Fast dissolving tablets (FDTs): Current status, new market opportunities, recent advances in manufacturing technologies and future prospects. Int J Pharm Pharm Sci 2014;6:22-35.
3. Kumar S, Mudili S. Formulation and evaluation of statistically designed ibuprofen fastdissolving tablets employing starch glutamate as a novel superdisintegrant. Asian J Pharm Clin Res 2019;12:85-94.
4. Kumar RS, Yagnesh TN, Kumar VG. Optimisation of ibuprofen fast dissolving tablets employing starch xanthate using 23 factorial design. Int J Appl Pharm 2017;9:51-9.
5. Tayebi H, Mortazavi SA. Formulation and evaluation of a novel matrix-type orally disintegrating ibuprofen tablet. Iran J Pharm Res 2011;10:469-79.
6. Kumar RS, Yagnesh TN. Synthesis, characterization and evaluation of starch xanthate as a superdisintegrant in the formulation of fast dissolving tablets. Int J Appl Pharm 2018;10:249-58.
7. Kumar RS, Annu K, Latha BK, Mallika T. Design, optimization and evaluation of ibuprofen fast dissolving tablets employing starch phthalate-a novel superdisintegrant. Int J Curr Pharm Res 2019;11:47-53.
8. Swain RP, Satish P, Subudhi BB, Panda S. Formulation and optimization of orodispersible tablets of ibuprofen. Int J Pharm Pharm Sci 2015;7:441-7.
9. Purkayastha HD, Nath B. Formulation and evaluation of oral fast disintegrating tablet of ibuprofen using two super disintegrants. Int J Curr Pharm Res 2017;9:92-5.
Statistics
35 Views | 46 Downloads
Citations
How to Cite
KUMAR RADA, A., R. M, and S. KANDUKURI. “DESIGN, OPTIMIZATION, AND EVALUATION OF IBUPROFEN FAST-DISSOLVING TABLETS EMPLOYING STARCH VALERATE – A NOVEL SUPER DISINTEGRANT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 14, no. 5, May 2021, pp. 91-98, doi:10.22159/ajpcr.2021.v14i5.41256.
Section
Original Article(s)