FABRICATION AND ASSESSMENT OF LERCANIDIPINE HYDROCHLORIDE SOLID DISPERSIONS FOR SOLUBILITY PREFERMENT USING POLYMER COMBINATION

NAZEMOON REDDY; SWARNALATHA DUGASANI; DEVANNA NAYAKANTI

doi:10.22159/ajpcr.2021.v14i7.41972

Authors

NAZEMOON REDDY Research Scholar, Department of Research and Development, Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, India.
SWARNALATHA DUGASANI Principal and Professor, Department of Pharmacognosy, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India.
DEVANNA NAYAKANTI Director, Jawaharlal Nehru Technological University, Oil Technological and Pharmaceutical Research Institute, Anantapur, Andhra Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i7.41972

Keywords:

Lercanidipine, Polymer, Solid dispersions, Dissolution

Abstract

Objective: An attempt has made in fabricating solid dispersions (SDs) by taking lercanidipine hydrochloride (LCD) as a model drug.

Methods: The SDs were made using a poly mix of poly vinyl pyrrolidone (PVP) K-30, Poloxamer-188, and hydroxy propyl methyl cellulose (HPMC) K4M. Different proportions of LCD: polymer mix in 1:1, 1:3, 1:5, and 1:7 ratios were fabricated as SDs by solvent evaporation and melting method, further compressed into tablets. The LCD SDs were assessed for physicochemical, and LCD release possessions.

Results: The results were observed to be attractive with the increase in solubility LCD SD (F-3 and F-7) with 1:5 ratios of LCD.

Conclusion: The study concludes that the poly mix of PVP K-30, Poloxamer-188, and HPMC K4M and was found to be a better combination for elevating the solubility and release of LCD from the SDs.

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