• SHAKEEL AHMAD MIR Department of Clinical Pharmacology, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Jammu and Kashmir, India.
  • DANISH SHAKEEL Department of Computer Science Engineering, University Institute of Engineering, Chandigarh University, Mohali, Punjab, India.



Objective: Adherence is a multifactorial phenomenon. Medication-related factors have long been the focus of attention. However, the results are inconsistent.

Methods: In a cross-sectional questionnaire-based study of outpatients, we assessed 180 patients suffering from chronic conditions. The objective of this study is to determine the impact of medication regimen complexity on adherence to long-term drug therapies.

Results: 91.66% of patients receiving more than four drugs had good or high adherence. 80.94% of patients on thrice a day (or more) drug administration had good or high adherence. 91.66% of patients receiving drug therapy for more than 5 years had good or high adherence. In all other groups, the adherence was low. The adherence was significantly (p<0.05) and positively (rs=0.792 and 0.846) correlated to the frequency of drug administration and duration of treatment. Adherence was positively correlated to the number of drugs per day (rs=0.668) but the relationships were not statistically significant (p=0.102). All the correlations were large.

Conclusions: We found adherence positively correlated with medication regimen complexity. An improved understanding of the determinants of medication adherence is needed.

Keywords: Medication regimen complexity, Adherence, Long-term therapy, Chronic disease


Download data is not yet available.

Author Biography

SHAKEEL AHMAD MIR, Department of Clinical Pharmacology, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Jammu and Kashmir, India.

Associate Professor

Clinical Pharmacology


World Health Organization. Adherence to Long-Term Therapies: Evidence for Action. Geneva: World Health Organization; 2003.

Brown MT, Bussell JK. Medication adherence: WHO cares? Mayo Clin Proc 2011;86:304-14.

Gast A, Mathes T. Medication adherence influencing factors-an (updated) overview of systematic reviews. Syst Rev 2019;8:1-17.

Feenstra J, Grobbee DE, Jonkman FA, Hoes AW, Stricker BH. Prevention of relapse in subjects with congestive heart failure: The role of precipitating factors. Heart 1998;80:432-6.

Kim SJ, Kwon OD, Han EB, Lee CM, Oh SW, Joh HK, et al. Impact of number of medications and age on adherence to antihypertensive medications:A nationwide population-based study. Medicine 2019;98:e17825.

Naqvi AA, Hassali MA, Rizvi M, Zehra A, Iffat W, Haseeb A, et al. Development and validation of a novel general medication adherence scale (GMAS) for chronic illness patients in Pakistan. Front Pharmacol 2018;9:1124.

Andrew WR, Ginny DC, Denise AE, Mary TR, Morris W, Joel FF.Patterns of medication adherence and health care utilization among patients with chronic disease who were enrolled in a pharmacy assistance program.N C Med J 2014;75:310-8.

Shalansky SJ, Levy AR. Effect of number of medications on cardiovascular therapy adherence. Ann Pharmacother 2002;36:1532-9.

Billups SJ, Malone DC, Carter BL. The relationship between drug therapy noncompliance and patient characteristics, health-related quality of life, and health care costs. Pharmacotherapy 2000;20: 941-9.

Tamrat L, Gessesse GW, Gelaw Y. Adherence to topical glaucoma medications in Ethiopian patients. Middle East Afr J Ophthalmol 2015;22:59-63.

Monane M, Bohn RL, Gurwitz JH, Glynn RJ, Avorn J. Noncompliance with congestive heart failure therapy in the elderly. Arch Intern Med 1994;154:433-7.



How to Cite

MIR, S. A., and . D. SHAKEEL. “THE IMPACT OF MEDICATION REGIMEN COMPLEXITY ON ADHERENCE TO LONG-TERM THERAPIES”. Asian Journal of Pharmaceutical and Clinical Research, vol. 14, no. 9, Sept. 2021, pp. 40-43, doi:10.22159/ajpcr.2021.v14i9.42304.



Original Article(s)