A CROSS-SECTIONAL PHARMACOVIGILANCE STUDY ON ADVERSE DRUG REACTION IN A TERTIARY CARE TEACHING HOSPITAL
DOI:
https://doi.org/10.22159/ajpcr.2022.v15i1.42347Keywords:
Adverse drug reaction, Adverse drug reaction reporting form, Adverse drug reaction incidence, CDSCO reporting form, WHO causality assessment scalesAbstract
Objectives: This study was conducted to identify and report the adverse drug reactions (ADRs) which are occurring in pediatric and medicine departments in a tertiary care hospital at Vadodara.
Methods: A cross-sectional study was conducted for 6 months in-patient at a tertiary care teaching hospital. We enrolled the patients based on inclusion criteria and data was analyzed with the help of MS excel 7 and Graph pad Prism. Further, the assessments of type, severity, and preventability of reported ADRs were done using Wills and Brown classification, modified Schumock and Thornton severity scale, modified Hartwig and Siegel preventability scale.
Results: Data were collected from a total of two hundred patients of which twenty-six (13%) patients were affected with ADRs. Among twenty-six patients, females (64%) were more affected with ADRs when compared to males (36%). According to the department, most ADRs were observed in the medicine ward than in the pediatric. The highest number of ADRs was associated with antibiotics (46.1%). Based on the type of ADRs, Type B ADRs (77%) were more observed followed by Type A (7%) and Type C (8%).
Conclusions: The information obtained from our study will help clinical pharmacists and healthcare professionals to take precautions in the future and adopt certain measures for preventing the ADRs and hence help in promoting safer and rational drug use in institutions and improving the quality of patient care.
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Sundaran S, Abhijith PS, Alex A, Krishnan A, Jacob AT, Babu G, et al. Spontaneous adverse drug reaction reporting in a tertiary care hospital in Calicut. Asian J Pharm Clin Res 2018;11:283-5.
Shamna M, Dilip C, Ajmal M, Mohan PL, Shinu C, Jafer CP, et al. A prospective study on adverse drug reactions of antibiotics in a tertiary care hospital. Saudi Pharm J 2014;22:303-8.
Parthasarthi G, Hansen KN, Nahata M. Medication error and adverse drugs events. In: A Textbook of Clinical Pharmacy Practice. 2nd ed., Ch. 28. Telangana: Orient Blackswan Private Limited; 2012. p. 486-506.
Venkaraddi MC, Allu H, Prasanna K, Nambari H, Majjaru C. Adverse drug reaction monitoring and reporting at HSK hospital and research center-Bagalkot. Indian J Pharm Pract 2016;9:49-56.
Kalyani SS, Srihitha P, Sharma KA, Dharanija P, Bheemreddy SK. A prospective observational study on the incidence of adverse drug reactions in a tertiary care teaching hospital: A pharmacovigilance study. Int J Basic Clin Pharmacol 2019;8:2423.
Sharma PK, Misra AK, Gupta A, Singh S, Dhamija P, Pareek P, et al. A retrospective analysis of reporting of adverse drug reactions to oncology drugs: An experience from a national center of clinical excellence. Indian J Pharmacol 2018;50:273-8.
Arulmani R, Rajendran SD, Suresh B. Adverse drug reaction monitoring in a secondary care hospital in South India. Br J Clin Pharmacol 2008;65:210-6.
Shajahan J, Parathoduvil AA, Purushothaman S. An analysis of seriousness, predictability, and preventability of adverse drug reactions reported at a tertiary care teaching hospital in Kerala, India: A retrospective observational record-based study. Int J Basic Clin Pharmacol 2018;7:2433-8.
Shajahan J, Parathoduvil AA, Purushothaman S. An analysis of seriousness, predictability and preventability of adverse drug reactions reported at a tertiary care teaching hospital in Kerala, India: A retrospective observational record based study. Int J Basic Clin Pharmacol 2018;7:2433-8.
Ramesh M, Pandit J, Parthasarathi G. Adverse drug reactions in a South Indian hospital their severity and cost involved. Pharmacoepidemiol Drug Saf 2003;12:687-92.
Bates DW, Leape LL, Petrycki S. Incidence and preventability of adverse drug events in hospitalized adults. J Gen Intern Med 1993;8:289-94.
Babu LP, Robin N, Babu JV, Jose J, George S. Adverse drug reactions among drug-resistant tuberculosis treatment: An observational cohort study. Int J Pharm Pharm Sci 2021;13:50-5.
Rhythm, Gor AP, Gajjar B, Dalwadi Z, Goyal A. Analysis of adverse drug events reported at peripheral ADR monitoring centre in Gujarat. Int J Pharm Pharm Sci 2021;12:72-5.
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