• Harshal Nutanrao Pise Assistant Professor, SRTR Govt. Medical College, Ambajogai. Dist-Beed, Maharashtra.
  • Sudhir L. Padwal



Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed groups of drugs for variety of indications. However, they
are associated with many potential adverse drug reactions. The detailed information of these reactions is necessary to decrease the morbidity and
mortality associated with these reactions. Angioedema can be caused by many etiological factors including drugs. The NSAID induced angioedema
occurs infrequently but sometimes it may prove fatal if not treated promptly. The angioedema due to NSAIDs use may be caused due to increase in
production of Leukotriene due block in cyclooxygenase pathway. The mast cells and to lesser extent basophils plays a major role in pathogenesis of
angioedema. Early recognition and discontinuation of responsible NSAIDs should be done. Treatment with corticosteroids and antihistaminic is useful
in management of angioedema. The author reports a case of a patient with angioedema in association with use of Diclofenac.
Keywords: Angioedema, Diclofenac, Non-steroidal anti-inflammatory drugs, Leukotrienes.


Download data is not yet available.

Author Biography

Harshal Nutanrao Pise, Assistant Professor, SRTR Govt. Medical College, Ambajogai. Dist-Beed, Maharashtra.

Dept. Of Pharmacology,

Assistant Professor


Kaplan AP, Greaves MW. Angioedema. J Am Acad Dermatol 2005;53(3):373-88.

Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30(2):239-45.

Hartwig SC, Siegel J, Schneider PJ. Preventability and severity assessment in reporting adverse drug reactions. Am J Hosp Pharm 1992;49(9):2229-32.

Schumock GT, Thornton JP. Focusing on the preventability of adverse drug reactions. Hosp Pharm 1992;27(6):538.

Arnon B. Angioedema-Induced by angiotensin converting enzyme inhibitors. J Clin Case Rep 2012;2(10):153.

Ferdman RM. Urticaria and angioedema. Clin Ped Emerg Med 2007;8:72-80.

Leeyaphan C, Kulthanan K, Jongjarearnprasert K, Dhana N. Drug-induced angioedema without urticaria: Prevalence and clinical features. J Eur Acad Dermatol Venereol 2010;24(6):685-91.

Martín E, Gómez A, Hinojosa B, Sáenz de San Pedro B, Florido F, Quiralte J. Diclofenac-induced reactions: A clinical study of 32 patients. Alergol Immunol Clin 2001;16:202-8.

Zembowicz A, Mastalerz L, Setkowicz M, Radziszewski W, Szczeklik A. Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs. Arch Dermatol 2003;139(12):1577-82.



How to Cite

Pise, H. N., and S. L. Padwal. “DICLOFENAC INDUCED ANGIOEDEMA: A CASE REPORT”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 2, Mar. 2015, pp. 4-5, https://innovareacademics.in/journals/index.php/ajpcr/article/view/4259.



Case Study(s)