• PRIYANKA ASWAL Department of Pathology, Government Medical College, Haldwani, Uttarakhand, India.
  • UPASANA BHUMBLA Department of Microbiology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.



Arrhythmias, Chronic obstructive pulmonary disease, Comorbidities


Objective: Chronic obstructive pulmonary disease (COPD) is the vital cause of morbidity and mortality in Western world, though it has become an increasing cause of mortality in India also in the past decade. Another concern is that COPD patients use medications that stimulate the cardiovascular system, including anticholinergic agents and sympathomimetic medications to study the prevalence of cardiovascular comorbidities in patients with COPD.

Methods: It was a prospective observational study, which was conducted on inpatient subjects diagnosed to have COPD based on GOLD guidelines 2020, for a period of 1 year in tertiary care hospital.

Results: The most of the patients were in 60–80 year age group (70%) and majority was males (87%). All the males (n=87) were smokers (62 ex-smokers and 25 present smokers) while all females (n=13) were non-smokers. The mean BMI for patients with CVD was 25.85±4.19 kg/m2 while for patients without CVD, mean BMI was 27.46±3.98 kg/m2. About 63.2% of the males (n=87) had some cardiovascular comorbidity as compared to 38.5% of females (n=13). The prevalence of cardiovascular comorbidities in subjects with COPD was 60% in the present study. This was significantly higher in patients with COPD as compared to the reported prevalence value in the general population of comparable age group. The prevalence of associated cardiovascular abnormality in COPD patients with increased PCV (Packed cell volume), leukocytosis, and neutrophilia are 56.3%, 65%, and 60%, respectively. The most common cardiovascular comorbidity in subjects with COPD was ischemic heart disease (21%), followed by heart failure (20%), stroke (5%), arrhythmias (3%), and LVH (3%).


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Author Biography

UPASANA BHUMBLA, Department of Microbiology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.

Senior Resident , Dept. Of Microbiology, All India Institute of Medical Sciences


Mannino DM, Homa DM, Akinbami LJ, Ford ES, Redd SC. Chronic obstructive pulmonary disease surveillance: United States, 1971-2000. MMWR Surveill Summ 2002;51:1-16. PMID 12198919

Chen JC, Mannino DM. Worldwide epidemiology of chronic obstructive pulmonary disease. Curr Opin Pulm Med 1999;5:93-9. doi: 10.1097/00063198-199903000-00003, PMID 10813258

Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global burden of disease study. Lancet 1997;349:1436-42. doi: 10.1016/S0140-6736(96)07495-8, PMID 9164317

Murray CJ, Lopez AD. Regional patterns of disability-free life expectancy and disability-adjusted life expectancy: Global burden of disease study. Lancet 1997;349:1347-52. doi: 10.1016/S0140- 6736(96)07494-6, PMID 9149696

Finkelstein J, Cha E, Scharf SM. Chronic obstructive pulmonary disease as an independent risk factor for cardiovascular morbidity. Int J Chron Obstruct Pulm Dis 2009;4:337-49. doi: 10.2147/copd.s6400, PMID 19802349

Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease (GOLD 2021 Guidelines). Geneva: World Health Organization; 2021.

Mannino DM, Thorn D, Swensen A, Holguin F. Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. Eur Respir J 2008;32:962-9. doi: 10.1183/09031936.00012408, PMID 18579551

Gupta R. Burden of coronary heart disease in India. Indian Heart J 2005;57:632-8.

Ghaffar A, Reddy KS, Singhi M. Burden of non-communicable diseases in South Asia. Br Med J. 2004;328:807-10.

Feary JR, Rodrigues LC, Smith CJ, Hubbard RB, Gibson JE. Prevalence of major co morbidities in subjects with COPD and incidence of myocardial infarction and stroke: A comprehensive analysis using data from primary care. Thorax 2010;65:956-62. doi: 10.1136/ thx.2009.128082, PMID 20871122

Curkendall SM, DeLuise C, Jones JK, Lanes S, Stang MR, Goehring E, et al. Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients. Ann Epidemiol 2006;16:63-70. doi: 10.1016/j. annepidem.2005.04.008, PMID 16039877

Agusti A, Calverley PM, Celli B, Coxson HO, Edwards LD, Lomas DA, et al, Evaluation of COPD longitudinally to identify predictive surrogate endpoints (ECLIPSE) investigators. Characterisation of COPD heterogeneity in the eclipse cohort. Respir Res 2010;11:122. doi: 10.1186/1465-9921-11-122, PMID 20831787

Mannino DM, Doherty DE, Sonia Buist A. Global initiative on obstructive lung disease (gold) classification of lung disease and mortality: Findings from the atherosclerosis risk in communities (ARIC) study. Respir Med 2006;100:115-22. doi: 10.1016/j.rmed.2005.03.035, PMID 15893923

Barr RG, Celli BR, Mannino DM, Petty T, Rennard SI, Sciurba FC, et al. Co morbidities, patient knowledge, and disease management in a national sample of patients with COPD. Am J Med 2009;122:348-55. doi: 10.1016/j.amjmed.2008.09.042, PMID 19332230

Johnston AK, Mannino DM, Hagan GW, Davis KJ, Kiri VA. Relationship between lung function impairment and incidence or recurrence of cardiovascular events in a middle-aged cohort. Thorax 2008;63:599-605. doi: 10.1136/thx.2007.088112, PMID 18245145

Buch P, Friberg J, Scharling H, Lange P, Prescott E. Reduced lung function and risk of atrial fibrillation in the Copenhagen city heart study. Eur Respir J 2003;21:1012-6. doi: 10.1183/09031936.03.00051502, PMID 12797497

Gupta R. Trends in hypertension epidemiology in India. J Hum Hypertens 2004;18:73-8. doi: 10.1038/sj.jhh.1001633, PMID 14730320

Van Manen JG, Bindels PJ, Ijzermans CJ, van der Zee JS, Bottema BJ, Schadé E. Prevalence of comorbidity in patients with a chronic airway obstruction and controls over the age of 40. J Clin Epidemiol 2001;54:287-93. doi: 10.1016/s0895-4356(01)00346-8, PMID 11223326

Mapel DW, Hurley JS, Frost FJ, Petersen HV, Picchi MA, Coultas DB. Health care utilization in chronic obstructive pulmonary disease: A case-control study in a health maintenance organization. Arch Intern Med 2000;160:2653-8. doi: 10.1001/archinte.160.17.2653, PMID 10999980

Walsh JW, Thomashow BM. COPD and Co-morbidities: Results of COPD Foundation National Survey. Paper Presented at: COPD and Comorbidities: Treating the Whole Patient. San Diego: ATS 2006 San Diego International Conference; 2006.

Trinkmann F, Saur J, Borggrefe M, Akin I. Cardiovascular comorbidities in chronic obstructive pulmonary disease (COPD)- current considerations for clinical practice. J Clin Med 2019;8:1-14. doi: 10.3390/jcm8010069, PMID 30634565



How to Cite

ASWAL, P., and U. BHUMBLA. “PREVALENCE OF CARDIOVASCULAR COMORBIDITIES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN SUBURBAN AREAS OF SOUTH-WEST INDIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 5, May 2022, pp. 72-75, doi:10.22159/ajpcr.2022.v15i5.43639.



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