A RANDOMIZED CONTROLL TRIAL TO COMPARE THE EFFICACY OF SACCHAROMYCES BOULARDII, BACILLUS CLAUSII, AND LACTOBACILLUS RHAMNOSUS GG PREPARATION IN THE TREATMENT OF ACUTE DIARRHEA IN CHILDREN
DOI:
https://doi.org/10.22159/ajpcr.2022.v15i4.44199Keywords:
Probiotics, Saccharomyces Boulardii, Bacillus Clausii, Lactobacillus RhamnosusGGAbstract
Objective: Probiotics have been recommended as an adjunct to standard treatment of acute diarrhea but the choice of probiotics is unclear. The aim of study is to compare the efficacy of Saccharomyces boulardii, Bacillus clausii versus Lactobacillus rhamnosus in children with acute diarrhea and to expand the tolerability of S. boulardii, B. clausii versus L. rhamnosus GG in acute diarrhea.
Methods: Hospital based Randomized Controlled Clinical trial (chit in box) carried out at the Department of Pediatrics, Mahatma Gandhi Hospital, Jaipur Rajasthan from January 2020 to June 2021. 120 Children were enrolled in the study and randomized to either Group A or Group B or Group C. Group A received S. boulardii, Group B received B. clausii and Group C received L. rhamnosus GG. Sample size was 40 samples for each group. Statistical analysis was done with the SPSS software.
Results: There was statistically significant improvement in consistency observed in Group C as compared to Group A an Group B (p<0.001). Significant higher cases (87.5%) were improved in Group C compare to Group B (67.5%), followed by Group A (65%). While all patients were observed well tolerated and accepted during the study.
Conclusions: In our study, L. rhamnosus GG significantly reduce the frequency, improve the consistency of stools in diarrhea as compared to B. clausii and S. boulardii while tolerability of S. boulardii, B. clausii and L. rhamnosus GG was good with no adverse effect.
Downloads
References
WHO. The Treatment of Diarrhea .AManual for Physicians and other Senior HealthWorkers;WHO/CDR/95.3.Geneva:WorldHealthOrganization,199
UNICEF.―DiarrhoeaOctober2019.‖2019.Availableat:https://data.unicef.org/topic
/child-health/diarrhoeal-disease/
World Health Organization (WHO). Diarrhoeal Disease: Fact Sheet. 2017. Availableonline: http://www.who.int/mediacentre/factsheets/fs330/en/(accessed on 2 March2018).
Guarner,F.;Schaafsma,G.J.Probiotics.Int.J.FoodMicrobiol.1998;39:237–238.
Matsuzaki,,T.;Chin,J. Modulating immune responses with probioticbacteria.Immunol. Cell. Biol.2000;78:67–73.
Cheikhyoussef, A.; Pogori, N.; Chen, W.; Zhang, H. Antimicrobial proteinaceouscompounds obtained from bifidobacteria: From production to their application. Int. J.FoodMicrobiol.2008;125: 215–222
Abedi, D.; Feizizadeh, S.; Akbari, V.; Jafarian-Dehkordi, A.In vitro anti-bacterialand antiadherence effects of Lactobacillus delbrueckiisubsp bulgaricusonEscherichiacoli. Res. Pharm. Sci.2013;8 : 260–268.
Expert consensus document. The International Scientific Association for Probioticsand Prebiotics consensus statement on the scope and appropriate use of the termprobiotic.
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB,Flint HJ, Salminen S, Calder PC, Sanders MENat Rev GastroenterolHepatol. 2014Aug;11(8):506-14.
A proposed framework for an appropriate evaluation scheme for microorganisms asnovelfoods with a healthclaim in Europe.
MiquelS,BeaumontM,MartínR,LangellaP,BraescoV,ThomasMMicrobCellFact.
Apr9;14():48.
Theuseofprobioticsinpediatricgastroenterology:areviewoftheliteratureandrecommendationsbyLatin-American experts.
CruchetS,FurnesR,MaruyA,HebelE,PalaciosJ,MedinaF,RamirezN,OrsiM,RondonL, Sdepanian V, Xóchihua L, Ybarra M, Zablah RA
PaediatrDrugs.2015Jun;17(3):199-216.
Keya Lahiri elat.BacillusClausii As An Adjuvant Therapy In Acute ChildhoodDiarrhoea. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS).1st May2015; 14 (5):74-76.www.iosrjournals.org
Irfan,Muhammad&Zaidi,Mustansir&Waseem,Hira.(2017).Associationofsocio-demographic factors with diarrhea in children less than five years: a secondaryanalysis of multiple indicator cluster survey sindh 2014. Pakistan journal of PublicHealth.7. 85-89.
DrAjeetGopchade.ElectrolyteDisturbancesinChildrenPresentingwithAcuteDiarrhea:A ProspectiveCohortStudy.JMSCR 2019;9(7).J
MWilundaC,PanzaA.Factors associated with diarrhea among children lessthan5yearsoldinThailand:asecondaryanalysisofThailandmultipleindicatorclustersurvey2006. Jhealth Res. 2009;23:17-22
SiziyaS,MuulaAS,RudatsikiraE.Diarrhoeaand acute respiratory infectionsprevalenceandriskfactorsamongunder-□vechildreninIraqin2000.ItalianJPediat.2009;35(1):1
Dr. G. KalyanChakravarthi, &Dr. R. Praveen Kumar. (2019). Study on incidences ofelectrolytedisordersamongchildrenwithdehydration. PediatricReview:InternationalJournal of Pediatric Research, 6(7),352-358.
NistaEC,CandelliM,CremoniniF,CazzatoIA,ZoccoMA,FranceschiF,etal.
Bacillus clausii therapy to reduce side effects of anti-helicobacter pylori treatment:randomized, double-blind, placebo-controlled trial. AlimetPhamacolTher.2004;20:1181–1188. doi: 10.1111/j.1365-2036.2004. 02274.
Lanata CF, Fischer-Walker CL, Olascoaga AC, Torres CX, Aryee MJ, Black RE:Globalcauses of diarrheal diseasemortalityin children
RobertoBerniCanani.Probioticsfortreatmentofacutediarrhoeainchildren:randomisedclinicaltrialoffivedifferentpreparations. BritishMedicalJournal.18August2007;335(7615):340-342
Salloju Vineet etal. Efficacy of Bacillus clausii Vs Saccharomycesboulardii inTreatment ofAcute Rotaviral Diarrhea in Pediatric Patients. Indonesian Journal ofClinicalPharmacy.June2017;6(2):1-6
Ianiro G, Rizzatti G, Plomer M, Lopetuso L, Scaldaferri F, Franceschi F, CammarotaG, Gasbarrini A. Bacillus clausii for the Treatment of Acute Diarrhea in Children: ASystematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients.2018;10(8):1074. https://doi.org/10.3390/nu10081074
Velasco, María et al. Probiotic Yogurt for the Prevention of Antibiotic-associatedDiarrheainAdults.JournalofClinicalGastroenterology.November/December2019;53 (10): 717-723 .doi:10.1097/MCG.0000000000001131
de Castro JA, Guno MJ, Perez MO. Bacillus clausii as adjunctive treatment for acutecommunity-acquireddiarrheaamong Filipino children: a large-scale,multicenter,open-labelstudy (CODDLE).TropDisTravelMedVaccines.2019;5:14. https://doi.org/10.1186/s40794-019-0089-5.
Szajewska H, Guarino A, Hojsak I, Indrio F, Kolacek S, Shamir R, et al. Use ofprobioticsformanagementofacutegastroenteritis:apositionpaperbytheESPGHAN Working Group for Probiotics and Prebiotics. J PediatrGastroenterolNutr2014;58:531-9.
VanNiel CW, Feudtner C, Garrison MM, Christakis DA. Lactobacillus therapy foracuteinfectiousdiarrheainchildren:ameta-analysis.Pediatrics.2002;109(4):678–84.
Boyle RJ, Robins-Browne RM, Tang ML. Probiotic use in clinical practice: what aretherisks?. American Journal ofClinical Nutrition 2006;83(6):1256–64. 55
Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and safety of Saccharomycesboulardiiforacutediarrhea. Pediatrics.2014; 134:e176–e191.10.1542/peds.2013-3950
Published
How to Cite
Issue
Section
Copyright (c) 2022 Abhishek kumar Sharma, NEERAJ PURI, MADHU MATHUR, AMIT MATHUR
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
