MANAGEMENT OF COVID ASSOCIATED ORBITAL MUCORMYCOSIS IN TERTIARY CARE HOSPITAL

Authors

  • VEJENDLA BHAVYA SRI SAI Department of Ophthalmology, Government Regional Eye Hospital, Visakhapatnam, Andhra Pradesh, India. https://orcid.org/0000-0002-6818-5721
  • KATTOJU PADMAVATHI Department of Ophthalmology, Government Regional Eye Hospital, Visakhapatnam, Andhra Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i11.45339

Keywords:

COVID-19 associated mucormucosis, Orbital mucormycosis, Diabetes mellitus in mucormycosis, Corticosteroids in mucormycosis, Management of mucormycosis

Abstract

Objectives: The aim of the study was to study epidemiological characteristics and management of orbital mucormycosis in cases of rhino-orbital mucormycosis in tertiary care hospital.

Methods: It is a retrospective study of 258 patients presenting to KGH, Visakhapatnam, over a duration of 3 months from June to August 2021. After taking detailed history regarding symptoms of mucormycosis, visual acuity was noted, slit lamp examination was done and necessary investigations such as microbiology, pathology specimens were sent and analyzed, imaging done, and management done accordingly.

Results: The majority of patients came with ENT-related symptoms were treated with endoscopic debridement, that is, 216 (84%), endoscopic debridement with orbital decompression of 23 (9%), transcutaneous retrobulbar amphotericin B of 21 (8%), orbital exenteration of 17 (6.5%), total and partial maxillectomy of 28 (10.8%), temporal lobe abscess drainage of 7 (2.7%), frontal lobe abscess drainage of (1.16%), frontal bone abscess drainage of 3 (1.16%), dural abscess drainage of 6 (2.3%), 15 (5.8) treated conservatively, and 30 (11.6%) death.

Conclusion: COVID-19 infection in presence of glycemic dysregulation predisposes to development of Rhino-orbital-cerebral mucormycosis. Strict glycemic control and judicious use of corticosteroids might help in decrease incidence of mucormycosis cases. Most of the patients presents with ENT-related symptoms if not treated early may spread to orbit and intracranial sites. Early treatment during early presentation might help prevent spreading orbital extension and intracranial extension.

Downloads

Download data is not yet available.

References

Arora R, Goel R, Khanam S, Kumar S, Shah S, Singh S, et al. Rhino-orbito-cerebral-mucormycosis during the COVID-19 second wave in 2021-A preliminary report from a single hospital. Clin Ophthalmol 2021;15:3505-14. doi: 10.2147/OPTH.S324977, PMID 34429582, PMCID PMC8380130

Sen M, Honavar SG, Bansal R, Sengupta S, Rao R, Kim U, et al. Epidemiology, clinical profile, management, and outcome of COVID- 19-associated rhino-orbital-cerebral mucormycosis in 2826 patients in India-collaborative OPAI-IJO study on mucormycosis in COVID-19 (COSMIC), Report 1. Indian J Ophthalmol 2021;69:1670-92. doi: 10.4103/ijo.IJO_1565_21, PMID 34156034, PMCID PMC8374756

Ramaswami A, Sahu AK, Kumar A, Suresh S, Nair A, Gupta D, et al. COVID-19-associated mucormycosis presenting to the emergency department-an observational study of 70 patients. QJM 2021;114:464-70. doi: 10.1093/qjmed/hcab190, PMID 34254132, PMCID PMC8420631

Singh AK, Singh R, Joshi SR, Misra A. Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India. Diabetes Metab Syndr 2021;15:102146. doi: 10.1016/j.dsx.2021.05.019. PMID 34192610, PMCID PMC8137376

Pakdel F, Ahmadikia K, Salehi M, Tabari A, Jafari R, Mehrparvar G, et al. Mucormycosis in patients with COVID-19: A cross-sectional descriptive multicentre study from Iran. Mycoses 2021;64:1238-52. doi: 10.1111/myc.13334, PMID 34096653

Honavar SG. Code mucor: Guidelines for the diagnosis, staging and management of rhino-orbito-cerebral mucormycosis in the setting of COVID-19. Indian J Ophthalmol 2021;69:1361-5. doi: 10.4103/ijo. IJO_1165_21, PMID 34011699

Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, et al. Post-acute COVID-19 syndrome. Nat Med 2021;27:601-15. doi: 10.1038/s41591-021-01283-z, PMID 33753937

Published

07-11-2022

How to Cite

SRI SAI, V. B., and K. PADMAVATHI. “MANAGEMENT OF COVID ASSOCIATED ORBITAL MUCORMYCOSIS IN TERTIARY CARE HOSPITAL”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 11, Nov. 2022, pp. 3-6, doi:10.22159/ajpcr.2022.v15i11.45339.

Issue

Section

Case Study(s)

Most read articles by the same author(s)