ASSESSMENT OF ANTI-OBESITY ACTIVITY OF TECTONA GRANDIS LEAVES ON BUTTER INDUCED HYPERLIPIDEMIA IN MICE
Keywords:Obesity, AETG, High-fat diet, Antiobesity, Atorvastatin
Introduction: Obesity is one of the world’s leading problems, which is major cause of cardiovascular diseases. During COVID-19 pandemic many young children and all age group people are getting challenged by obesity due stagnant life style. To treat such life-threatening disorder natural remedies acquire prior position, plant produces a good deal of secondary metabolites which have a benefited mankind in various ways, including treatment of diseases. The present research work was focused on developing a natural remedy using Tectona grandis, an ancient plant with number of proven activities in traditional medicine.
Methods: In the literature survey, it was found that flavonoids, sterols, tannins, and alkaloids shown promising effects to tackle obesity by various mechanisms, T. grandis has shown the presence of saponins, alkaloids, flavonoids, proteins, and amino acids. With the above evidence, this plant has been selected for screening of its antiobesity activity against high-fat diet induced obesity in mice. Studies were conducted using aqueous extract of T. grandis leaves (AETG) on high-fat diet (butter) induced model of hyperlipidemia in mice. During 21 days’ time period AETI low and high doses were induced to respective animal groups along with butter where atorvastatin has been taken as standard drug. Butter enhanced the cholesterol and triglyceride, low-density lipoprotein (LDL) levels.
Results and Discussion: At the end of 21 days, blood samples were collected from the animal through retroperitoneal route. Biochemical parameters of AETG have been compared with that of standard drug group of animals. The test results were almost similar and for some particular parameters such as LDL and very low-density lipoprotein, AETG shown good results than standard drug results.
Conclusion: In congruence with these results, it may be confirmed that due to the presence of phytoconstituents such as saponins, flavonoids, proteins, terpenoids, amino acids, and alkaloids in the aqueous extract of T. grandis, it could be responsible for the observed significant anti-obesity activity.
Alasmari HD, Al-Shehri AD, Aljuaid TA, Alzaidi BA, Alswat KA. Relationship between body mass index and obesity awareness in school students. J Clin Med Res 2017;9:520-4. doi: 10.14740/jocmr2987w, PMID 28496554
Carbonell T, Freire E. Binding thermodynamics of statins to HMG-CoA reductage. Biochemistry 2005;44:11741-8. doi: 10.1021/bi050905v, PMID 16128575
Li J, Chen YP, Li X, Armitage J, Feng F, Liu JM, et al. Use of secondary preventive medications in patients with atherosclerotic disease in urban China: A cross-sectional study of 16, 860 patients. Chin Med J (Engl) 2012;125:4361-7. PMID 23253702
Gao F, Zhou YJ, Hu DY, Zhao YX, Liu YY, Wang ZJ, et al. Contemporary management and attainment of cholesterol targets for patients with dyslipidemia in China. PLoS One 2013;8:e47681.
Adams SP, Tsang M, Wright JM. Lipid lowering efficacy of atorvastatin. Cochrane Database Syst Rev 2012;12:CD008226.
Ye YC, Zhao XL, Zhang SY. Use of atorvastatin in lipid disorders and cardiovascular disease in Chinese patients. Chin Med J (Engl) 2015;128:259-66. doi: 10.4103/0366-6999.149226, PMID 25591572
Kamsu GT. Chuisseu DP, Gasting D, Chegaing SP, Feudjio HB, Famen LC, et al. Toxicological profile of the aqueous etraction of Tectona grandis. L. F.(Verbenaceae) Leaves: A medicinal plant used in the treatment of typhoid fever in traditional Cameroonian medicine. J Toxicol 2021;2021:6646771.
Asdaq SM, Nayeem N, Abida, Alam MT, Alaqel SI, Imran M, et al. Tectona grandis L.F: A comprehensive review on its patents, chemical constituents, and biological activities. Saudi J Biol Sci 2022;29:1456- 64. doi: 10.1016/j.sjbs.2021.11.026
Sachan K, Singh PK, Ashwlayan VD, Singh R. Evaluation of hepatoprotective activity of Tectona grandis linn. Int J Pharm Res 2014;2:105-8.
Lanka S, Paimala. Antimicrobial activities of Tectona grandis leaf and bark extracts. EJPMR 2017;4:245-8.
Ogunmefun OT, Ekundayo EA, Akharaiyinand FC, Ewhenodere D. Phytochemical screening and antibacterial activities of Tectona grandis. L.f.(Teak) leaves on microorganisms isolated from decayed food samples. Trop Plant Res 2017;4:376-82.
Kushwah AS, Kaur P, Ramandeep S. In-vitro antioxidant potential and phytochemical screening of Tectona grandis Linn. leaves. IJPMR 2013;1:33-8.
Ghareeb MA, Shoeb HA, Madkour HM, Refaey LA, Mohamed MA, Saad AM. Antioxidant and cytotoxic activities of Tectona grandis linn. leaves. IJP 2014;5:143-57.
Krishna MS, Nair AJ. Antibacterial, cytotoxic and Antioxidant potential of different extracts from leaf, bark, and wood of Tectona grandis. IJPSDR 2010;2:155-8.
Varma SB, Giri SP. Study of wound healing activity of Tectona grandis linn leaf exacts on rats. Anc Sci Life 2013;32:241-4.
Khan RA, Siddiqui SA, Azhar I, Ahmed SP. Preliminary screening of methanol and butanol extracts of Tamarindus indica for antiemetic activity. J Basic Appl Sci 2005;1:51-4.
Tayade P, Borde SN, Jagtap SA. Effect of Tamarindus indica Linn. Against isolated goat tracheal and guinea pig ileum preparation. Int J Compr Pharm. 2010;2:1-3.
Gundamaraju R, Mulaplli SB, Ramesh C. Evaluation of anti-obesity activity of Lantana camara Var Linn. by progesterone induced obesity on albino mice. Int J Pharmacogn Phytochem Res 2013;4:213-8.
Amatayakul K, Sivasomboon B, Thanangkul O. A study of the mechanism of weight gain in medroxyprogesterone acetate users. Contraception. 1980;22:605-22.
Berteri RA. Risk of coronary artery heart disease. Health Screen 2003;1:28-9.
Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet 2014;384:626-35. doi: 10.1016/S0140-6736(14)61177-6, PMID 25131982
Nordestgaard BG, Wootton R, Lewis B. Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media. Arterioscler Thromb Vasc Biol 1995;15:534- 42. doi: 10.1161/01.atv.15.4.534, PMID 7749867
Goldberg IJ, Eckel RH, McPherson R. Triglycerides and heart disease: Still a hypothesis? Arterioscler Thromb Vasc Biol 2011;31:1716-25.
Navab M, Reddy ST, Brian J. HDL and cardiovascular disease: Atherogenic and atheroprotective mechanisms. Nat Rev Cardiol 2011;8:222-32.
How to Cite
Copyright (c) 2022 JAKKA LAKSHMI PRASANNA, NAKKA MADHAVA RAO, BADDIGAM VENKATA SAI KUMAR REDDY
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.