PHARMACOLOGICAL POTENTIAL OF POLYHERBAL AYURVEDIC FORMULATIONS – A REVIEW
Keywords:Arishta, Asava, Ayurveda
Ayurveda is an ancient traditional medical care system. The major aim of Ayurveda is to prevent unnecessary suffering and aiding healthy long life. Ayurveda incorporates natural constituents to make potential medicines that are believed to eliminate the root cause of the diseases. Forty-five thousand plant species are found in the subcontinent of India making it one of the largest biodiversity centers. In India alone, 15,000 medicinal plant species have been reported out of which 7500 species are used by the communities to cure different diseases. Ayurveda uses single or polyherbal for treatment. In these traditional medicine systems, various formulations are prepared one of which is fermented formulations, namely, arishtas and asavas. These formulations are prepared using a decoction of herbal drugs and contain self-generated alcohol. Fermented formulations are known for their stability and efficacy. Indian traditional literature states the usage of these formulations regularly with scientific validation strengthens one immunity and well-being. The current review focuses on Vidangarishta. Punarnavasava, Chandanasava, their preparations, therapeutics uses, and their toxic effects. A thorough understating of these formulations aids in standardizing Ayurveda as a marginalized medicine.
Chandra S. Ayurvedic research, wellness and consumer rights. J Ayurveda Integr Med 2016;6:6-10.
Sayyad SF, Randive DS, Jagtap SM, Chaudhari SR, Panda BP. Preparation and evaluation of fermented ayurvedic. J Appl Pharm Sci 2012;2:122-4.
Debas HT, Laxminarayan R, Straus SE. Complementary and Alternative Medicine in Disease Control Priorities in Developing Countries. Washington, DC: Oxford Univeristy Press; 2006.
Karunamoorthi K, Jegajeevanram K, Vijayalakshmi J, Mengistie E. Traditional medicinal plants: A source of phytotherapeutic modality in resource-constrained health care settings. J Evid Based Complement Altern Med 2013;272:67-74.
Hankey A. Ayurveda and the battle against chronic disease: An opportunity for ayurveda to go mainstream? J Ayurveda Integr Med 2010;1:9-12.
Chauhan A, Semwal DK, Mishra SP, Semwal RB. Ayurvedic research and methodology: Present status and future strategies. Ayu 2015;36:364-9.
Sawarkar G, Sawarkar P. Significance of diet and behavior during pandemic situation according to ayurveda. In: Contemporary Developments and Perspectives in International Health Security. London: Intech; 2021.
Talwar S, Sood S, Kumar J, Chauhan R, Sharma M, Tuli HS. Ayurveda and allopathic therapeutic strategies in coronavirus pandemic treatment. Curr Pharmacol Rep 2020;6:354-63.
Sekar S, Vinothkanna A. Polyherbal and submerge fermented medicines of ayurveda: Convergence of tradition with scientific trends and needs. South Afr J Bot 2019;121:410-7.
Kesarwani K, Gupta R, Mukerjee A. Bioavailability enhancers of herbal origin: An overview. Asian Pac J Trop Biomed 2013;3:253-66.
Das C, Ghosh G, Das D. Ayurvedic liquid dosage form asava and arista: An overview. Indian J Pharm Educ Res 2017;51:169-76.
Thakur A, Kumari S, Sharma S, Baghel D. Sandhana Kalpana: A progressive review. Int J Green Pharm 2018;12:1595.
Chaudhary A, Singh N, Dalvi M, Wele A. A progressive review of Sandhana Kalpana (biomedical fermentation): An advanced innovative dosage form of ayurveda. Ayu 2011;32:408-17.
Konwar A. A review on: Fermented alcoholic beverages; its preservation, shelf life extension and value addition. Curr Trends Pharm Res 2022;8:54-72.
Das C, Ghosh G, Bose A, Das D. Analytical methods for standardization of ayurvedic asavas and aristas; a review. Indian J Pharm Sci 2019;81:396-405.
Pandiar D, Baranwal HC, Kumar S, Ganesan V, Sonkar PK, Chattopadhyay K. Use of jaggery and honey as adjunctive cytological fixatives to ethanol for oral smears. J Oral Maxillofac Pathol 2017;21:317.
Sharma R, Garg P, Kumar P, Bhatia SK, Kulshrestha S. Microbial fermentation and its role in quality. Fermentation 2020;6:1-20.
Gurung N, Ray S, Bose S, Rai V. A broader view: Microbial enzymes and their relevance in industries. Medicine, and beyond. BioMed Res Int 2013;2013:1-19.
Manwar J, Mahadik K, Paradkar A, Sathiyanarayanan L, Vohra M, Patil S. Isolation, biochemical and genetic characterizations of alcohol-producing yeasts from the flowers of Woodfordia fruticosa. J Young Pharm 2013;5:191-4.
Suma MV, Mallikarjun A, Aithal R. Relevance of dhataki flowers in fermentation procedure, pharamceutico-analytical and microbiological study. J Natl Ayurvedic Med 2019;3:000207.
International Centre for Science and High Technology. Extraction Technologies for Medicinal and Aromatic Plants. Trieste, Italy: United Nations Industrial Development Organization and the International Centre for Science and High Technology; 2008.
Mulay S, Khale A. Asavarishtas through improved fermentation technology. Int J Pharm Sci Res 2011;2:1421-245.
Neve J, Dharkar N. Review on ushirasava (fermented traditional medicine of ayurveda). J Ayurveda Integr Med Sci 2019;4:218-25.
Balakrishnan R, Vijayraja D, Jo SH, Ganesan P, Su-Kim I, Choi DK. Medicinal profile, phytochemistry, and pharmacological activities of Murraya koenigii and its primary bioactive compounds. Antioxidants 2020;9:101.
Singh V, Narwaria A, Katiyar C. Asava-aristha: A Multi-advantageous Fermented Product in Ayurveda. High Value Fermentation Products, Kolkata, Research and Development Ayurveda-health Care Division. Kolkata: Emami Limited; 2019. p. 89-108.
Sekar S, Mariappan S. Traditionally fermented biomedicines, arishtas and asavas from ayurveda. Indian J Tradit Knowl 2008;7:548-56.
Jäger S, Beffert M, Hoppe K, Nadberezny D, Frank B, Scheffler A. Preparation of herbal tea as infusion or by maceration at room temperature using mistletoe tea as an example. Sci Pharm 2011;79:145-55.
Shankar K, Amritpal S. Standardisation of polyherbal ayurvedic formulation-chandanasava. Int J Res 2011;2:665-9.
Haridas M, Sabu A. Fermentation in ancient ayurveda: Its present implications. Front Life Sci 2015;8:324-31.
Alam M, Rukmani B, Shanmughadasan KK, Purushothaman KK. Effect of time on the fermentation and storage of chandanasava. Anc Sci Life 1984;4:51-5.
Vinothkanna A, Sekar S. Influence of intrinsic microbes on phytochemical changes and antioxidant activity of the ayurvedic fermented medicines: Balarishta and chandanasava. Ayu 2018;39:169-81.
Sekar S, Mariappan S, Annadurai V. Tracking the organoleptic and biochemical changes in the ayurvedic polyherbal and native fermented traditional medicines: Balarishta and chandanasava. Int J Pharm Pharm Sci 2014;6:521-6.
Badukale NA, Panchale WA, Manwar JV, Gudalwar BR, Bakal RL. Phytochemistry, pharmacology and botanical aspects of Madhuca indica: A review. Pharmacogn Phytochem 2021;10:1280-6.
Kumar R, Anjum N, Tripathi YC. Phytochemistry and pharmacology of Santalum album L: A review. World J Pharm Res 2015;4:1842-76.
Nath A, Dutta D, Kumar P, Singh JP. Review on recent advances in value addition of jaggery based products. J Food 2021;6:4.
Patel R, Gautam P. Medicinal importance of ficus bengalensis: A review. Int J Med Chem Anal 2014;4:53-8.
Aishwarya, Chopra V, Kaur A, Kalsi V. An insight of Vitis vinifera (Draksha). J Emerg Technol Innov Res 2018;5:11.
Kumar S, Kamboj J, Suman, Sharma S. Overview for various aspects of the health benefits of Piper longum Linn. Fruit. J Acupunct Merid Stud 2011;4:134-40.
Bhinge SD, Desai P, Magdum CS. In vitro anthelmintic activity of leaf extracts of Adhatoda vasica Nees (Acanthaceae) against Eudrilus eugeniae. Dhakia Univ J Pharm Sci 2016;5:153.
Hullatti KK, Sharada MS. Comparative phytochemical investigation of the sources of ayurvedic drug patha: A chromatographic fingerprinting analysis. Indian J Pharm Sci 2010;72:39-45.
Chandrashekar BS, Prabhakara S, Mohan T, Shabeer D, Bhandare B, Nalini M, et al. Characterization of Rubia cordifolia L. root extract and its evaluation of cardioprotective effect in Wistar rat model. Indian J Pharmacol 2018;50:12-21.
Meena V, Chaudhary A. Manjistha (Rubia cardifiolia) - A helping herb in cure of acne. J Ayurveda Holist Med 2015;3:11-17.
Sahoo S, Das A, Mahalik G. An overview of Boerhavia diffusa plant used for the treatment of various diseases in Odisha. 2021;12:37559-66.
Mishra S, Aeri V, Gaur PK, Jachak SM. Phytochemical, therapeutic, and ethnopharmacological overview for a traditionally important herb: Boerhavia diffusa Linn. BioMed Res Int 2014;2014:808302.
Kaur H. Boerhaavia diffusa: Bioactive compounds and pharmacological activities. Biomed Pharmacol 2019;12:1675-1682.
Aggarwal BB, Prasad S, Reuter S, Kannappan R, Yadev VR, Park B, et al. Identification of novel anti-inflammatory agents from ayurvedic medicine for prevention of chronic diseases: “Reverse pharmacology” and “bedside to bench” approach. Curr Drug Targets 2011;12:1595- 653.
Verma P, Lal VK. Punarnava-A natural remedy by ayurveda. Int J Pharm Sci 2014;6:1-6.
Reddy DD. A Comparative Pharmaceutical and Experimental Study of Punarnacasava in the Form of Asava and Arishta W.SR. to Their Anti-Inflammatory Property,” Department of Post Graduate Studies In Bhaishajya Kalpana, A. L.N. Rao Memorial Ayurvedic Medical College, Chikmagalur, Karnataka; 2010.
Meghwal M, Goswami TK. Chemical composition, nutritional, medicinal and functional properties of black pepper: A review. Open Access Sci Rep 2012;1:1-5.
Mashhadi NS, Ghiasvand R, Askari G, Hariri M, Darvishi L, Mofid MR. Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: Review of current evidence. Int J Prev Med 2013;4:36-42.
Grover HS, Deswal H, Singh Y, Bhardwaj A. Therapeutic effects of amla in medicine and dentistry: A review. J Oral Res Rev 2015;7:65-8.
Aruna S, Nandakishore. Haritaki A Boon To Herbalism -A review. Scholars Acad J Biosci 2014;2:132-6.
DeFilipps RA, Krupnick GA. The medicinal plants of Myanmar. PhytoKeys 2018;102:1-341.
Fierascu I, Dinu-Pirvu CE, Fierascu RC, Velescu BS, Anuta V, Ortan A, et al. Phytochemical profile and biological activities of Satureja hortensis L.: A review of the last decade. Molecules 2018;23:2458.
Kumar S, Bhowmik D, Chiranjib, Tiwari P, Kharel R. Indian traditional herbs Adhatoda vasica and its medicinal application. J Chem Pharm Res 2010;2:240-5.
Kumar S, Parmar R. Studies on qualitative and quantitative phytochemical analysis of eranda moola (Ricinus communis Linn). World J Pharm Res 2019;777:2413-8.
Bhattacharjee S, Bhattacharya S, Singh JD. A review on medicinally important species of Picrorhiza a review on medicinally important species of Picrorhiza. Int J Pharm Res Biosci 2013;2:1-16.
Rajashekar V, Rao EU, Srinivas P. Biological activities and medicinal properties of Gokhru (Pedalium murex L.). Asian Pac J Trop Biomed 2012;2:581-5.
Joseph R, Rangasamy I, Patgiri BJ. Therapeutic potentials of Kantakari (Solanum xanthocarpum Schrad. and Wendl.). Ayurpharm Int J Ayur Alli Sci 2012;1:46-53.
Taru P, Syed S, Kute P, Shikalgar M, Kad D, Gadakh A. Dashamoola: A systematic overview. GIS Z Geoinform 2022;9:1334-45.
Sharma V, Hem K, Seth A, Maurya SK. Solanum indicum Linn.: An ethnopharmacological, phytochemical and pharmacological review. Curr Res J Pharm Allied Sci 2017;1:1-9.
Sofowora A, Ogunbodede E, Onayade A. The role and place of medicinal plants in the strategies for disease prevention. Afr J Tradit Complement Altern Med 2013;10:210-29.
Alzohairy MA. Therapeutics Role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evid Based Complement Altern Med 2016;2016:1-11.
Margaret S, Xinyue W, Tiffany H, James P. A comprehensive review of raisins and raisin components and their relationship to human health. J Nutr Health 2017;50:203-16.
Samarghandian S, Farkhondeh T, Samini F. Honey and health: A review of recent clinical research. Pharmacognosy Res 2017;9:121-7.
Nath AR, Awasthi V, Thamara K, Deepak NG, Kumar S. Evaluation of antibacterial and anthelminthic activity of fermented ayurvedic formulations. J Sci Res 2022;66:76-85.
Pantawane PG, Swan PS. Management of dadru kushtha: A case study. World J Pharm Res 2020;11:1826-33.
Patil RP, Patil PD, Thakar AB. Panchakarma in autoimmune pancreatitis: A single-case study. Ayu 2019;40:242-6.
Ministry of AYUSH. Ayurveda Standard Treatment Guidelines. New Delhi: Ministry of AYUSH- Government of India; 2017.
Goraya GS, Ved DK. Medicinal Plants in India: An Assessment of Their Demand and Supply. Dehradun: National Medicinal Plants Board and Indian Council of Forestry Research and Education- Government of India; 2017.
Tambekar DH, Khante BS, Chandak BR, Titare AS, Boralkar SS, Aghadte SN. Screening of antibacterial potentials of some medicinal plants from Melghat forest in India. Afr J Tradit Complement Altern Med 2009;6:228-32.
Choudhary N, Singh V. A census of P. longums phytochemicals and their network pharmacological evaluation for identifying novel drug-like molecules against various diseases, with a special focus on neurological disorders. PloS One 2018;13:e0191006.
Srivastava P. Therapeutic potential of Piper longum L. for disease. Int J Pharm Sci 2014;4:692-6.
Pandey P, Shankar P. Pluchea lanceolata- An overview. Int J Pharm Sci Rev Res 2018;52:133-41.
Jamadagni PS, PawarSD, Jamadagni SB, Chougule S, Gaidhani SN, Murthy SN. Review of Holarrhena antidysenterica (L.) Wall. ex A. DC. Pharmacognostic, pharmacological, and toxicological perspective. Pharmacognosy Rev 2017;11:141-4.
Mrinal S, Singh N. A review on pharmacological aspects of Holarrhena antidysenterica. Scholars Acad J Pharm 2018;7:488-92.
Mahto S, Mehta A, Roy S. Studies on antibacterial effects of bark, seed. The bioscan. An Int Q J Lifesci 2013;8:717-21.
Khan KH. Role of Emblica officinalis in medicine - A review. Bot Res Int 2009;2:218-28.
Jain PK, Das D, Pandey N, Jain P. Traditional Indian herb Emblica officinalis and its medicinal importance. Innov J Ayurvedic Sci 2016;4:1-15.
Bansal V, Medhi B, Pandhi P. Honey-a remedy rediscovered and its therapeutic utility. Kathmandu Univ Med J 2005;3:305-9.
Arawwawala M, Hewageegana S. Health benefits and traditional uses of honey: A review. J Apither 2017;2:9-14.
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