• SOUPARNIKA SR Department of Anaesthesiology, Government Medical College, Kottayam. India
  • SANTHI KS Department of Anaesthesiology, Government Medical College, Kottayam. India
  • SUSAN T CHEERAN Department of Anaesthesiology, Government Medical College, Kottayam. India



Melatonin, Stress response, Laryngoscopy, Intubation



 Objective: The aim of the study was to study the effects of melatonin in attenuation of hemodynamic responses such as heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean blood pressure (MBP) to laryngoscopy and intubation (L&I) in general anesthesia.

Methods: This was a prospective and observational study conducted in a tertiary care teaching hospital on 120 patients aged 20–45 years belonging to American Society of Anaesthesiologists Grade I, undergoing elective surgery under general anesthesia. Selected patients were allotted into Group A (control group) and Group B (patients who took tablet melatonin 6 mg, 120 min before induction) of 60 patients each. Hemodynamic parameters such as HR, systolic, diastolic, and MBPs were recorded before the administration of drug (baseline), 120 min after administration of study drug (just before induction), immediately after induction, at L&I, just after L&I and at 1, 3, 5, and 10 min thereafter.

Results: The gender distribution and mean age of both groups were comparable. Both the groups were also comparable with respect to baseline values of HR, systolic, diastolic, and mean arterial pressure. The control group showed significant increases in HR, SBP, DBP, and mean arterial blood pressure after L&I and this increase persisted for the next 10 min. In the melatonin group, there was no significant increase in HR, systolic, diastolic, or MBP at any point of measurement after L&I.

Conclusion: Pre-treatment with 6 mg oral melatonin 120 min before induction of anesthesia is effective for attenuating hemodynamic responses to L&I without significant side effects.


Download data is not yet available.


Henderson J. Airway management in the adult. In: Miller RD, editor. Miller’s Anaesthesia. 7th ed. Philadelphia, PA: Churchill Livingstone; 2010. p. 1573-610.

Gill NP, Wright B, Reilly CS. Relationship between hypoxaemic and cardiac ischaemic events in the perioperative period. Br J Anaesth 1992;68:471-3.

Brian JP, Norton ML. Principles of airway management. In: Healy TE, Knight PR, editors. Wylie and Churchill-Davidson’s. 7th ed. London: Arnold Press; 2003. p. 443.

Ugur B, Ogurlu M, Gezer E, Aydin ON, Gürsoy F. Effects of esmolol, lidocaine and fentanyl on haemodynamic responses to endotracheal intubation: A comparative study. Clin Drug Investig 2007;27:269-77.

Maitra S, Baidya DK, Khanna P. Melatonin in perioperative medicine: Current perspective. Saudi J Anaesth 2013;7:315-21.

Rosenberg J, Gögenur I, Lykkesfeldt J. Modification of surgical stress response by perioperative melatonin administration. Dan Med Bull 2010;57:4144.

Mohamed AA, Atef HM, El Kassaby AM, Ismail SA, Helmy AM. Effects of melatonin premedication on the hemodynamic responses and perfusion index during laryngoscopy and endotracheal intubation. Med J Cairo Univ 2013;81:859-67.

Ismail SA, Mowafi HA. Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anaesthesia. Anesth Analg 2009;108:1146-51.

Gupta P, Jethava D, Choudhary R, Jethava DD. Role of melatonin in attenuation of haemodynamic responses to laryngoscopy and intubation. Indian J Anaesth 2016;60:712-8.

Naguib M, Samarkandi AH. Premedication with melatonin: A double blind, placebo controlled comparison with midazolam. Br J Anaesth 1999;82:875-80.

Naguib M, Samarkandi AH, Riad W, Thalaj A, Alotibi W, Aldammas F, et al. Melatonin vs. midazolam premedication in children: A double-blind, placebo controlled study. Eur J Anaesthesiol 2005;22:189-96.



How to Cite

SOUPARNIKA SR, SANTHI KS, and SUSAN T CHEERAN. “ROLE OF MELATONIN IN ATTENUATION OF HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND INTUBATION IN GENERAL ANAESTHESIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 3, Mar. 2023, pp. 159-62, doi:10.22159/ajpcr.2023.v16i3.47544.



Original Article(s)