NOVEL SPECTROPHOTOMETRIC METHODS FOR THE QUANTIFICATION OF DESVENLAFAXINE IN PURE AND PHARMACEUTICAL DOSAGE FORM


U Sreeja, Bm Gurupadayya, Rs Chandan

Abstract


 

Objectives: Two simple, sensitive and economic spectrophotometric methods are developed for the determination of desvenlafaxine in pure and its
pharmaceutical formulations.
Methods: The developed methods are based upon the reaction of oxidative coupling of desvenlafaxine with 3-methyl-2-benzthiazolinonehydrazone
(MBTH) (Method A) and 2, 2’ bipyridyl (Method B) in the presence of ferric chloride. The colored complex produced was measured at 663 nm,
522 nm for method A and B respectively against the reagent blank. The optimum experimental parameters for the color productions are
selected.
Results: Beer’s law is valid within a concentration range of 20-100 μg/ml and 5-25 μg/ml and for method A, B respectively. The percentage recoveries
were found in the range of 99.47±0.1789 for method A and 100.08±0.144 for method B. The limit of detection and limit of quantification were found
to be 0.825 μg/ml and 2.5 μg/ml respectively for method A and 0.1061 μg/ml and 0.321 μg/ml for method B respectively.
Conclusion: The developed methods are applied for the determination of desvenlafaxine in bulk and its pharmaceutical formulations without any
interference from excipients.
Keywords: Spectrophotometric, Desvenlafaxine, Oxidative coupling, 3-methyl-2-benzthiazolinone hydrazone, 2, 2- bipyridyl, FeCl3.


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About this article

Title

NOVEL SPECTROPHOTOMETRIC METHODS FOR THE QUANTIFICATION OF DESVENLAFAXINE IN PURE AND PHARMACEUTICAL DOSAGE FORM

Date

01-03-2015

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 8 Issue 2 (March - April) 2015 Page: 267-270

Print ISSN

0974-2441

Online ISSN

2455-3891

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268 Views | 286 Downloads

Authors & Affiliations

U Sreeja
J S S College of Pharmacy, J S S University Shivarathreeshwara Nagar, MYSORE-570 015
India

Bm Gurupadayya
Dr. B.M.Gurupadayya Professor, Dept. of Pharmaceutical Chemistry, J S S College of Pharmacy, J S S University Shivarathreeshwara Nagar, MYSORE-570 015
India

Rs Chandan
J S S College of Pharmacy, J S S University Shivarathreeshwara Nagar, MYSORE-570 015, India
India


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