SYNTHESIS AND MOLECULAR DOCKING STUDIES OF ETHYL 1-BENZENESULFONYL -2-[(E)-2-(2 METHYLPHENYL) ETHENYL] INDOLE -3-CARBOXYLATE WITH HUMAN RENIN COMPLEXED WITH INHIBITOR

Authors

  • C. RAMATHILAGAM AMET University,Kanathur- 603112.Chennai.India.
  • AKHILESH UPGADE
  • ANUSHA BHASKAR
  • P.R.UMARANI
  • V.MANIVANNAN

Abstract

Various proteins play important roles in hypertension and a number of drugs have been tested for their efficacy in modulating hypertension. Renin is an aspartyl protease involved in the production of angiotensin II, a potent vasoconstrictor. Renin inhibitors can prevent blood vessel constriction and therefore could be useful for the treatment of hypertension. With this rationale, some new indole compound are synthesized and evaluated for their antihypertensive activity. Docking studies using Molegro Virtual Docker (MVD) on the human Renin complexed with inhibitor (PDB ID : 2IKO) show their role in the antihypertensive  activity of the molecule  and explain the higher potency of compound based on ReRanking score and binding poses of the molecule.

Keywords: Indole, Human Renin complexed with inhibitor, Molegro Virtual Docker,    Antihypertensive, Single XRD.

Author Biography

C. RAMATHILAGAM, AMET University,Kanathur- 603112.Chennai.India.

Physics Department

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Published

2013-10-01

How to Cite

RAMATHILAGAM, C., A. UPGADE, A. BHASKAR, P.R.UMARANI, and V.MANIVANNAN. “SYNTHESIS AND MOLECULAR DOCKING STUDIES OF ETHYL 1-BENZENESULFONYL -2-[(E)-2-(2 METHYLPHENYL) ETHENYL] INDOLE -3-CARBOXYLATE WITH HUMAN RENIN COMPLEXED WITH INHIBITOR”. Asian Journal of Pharmaceutical and Clinical Research, vol. 6, no. 4, Oct. 2013, pp. 96-99, https://innovareacademics.in/journals/index.php/ajpcr/article/view/501.

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