EVALUATION OF MUTAGENIC EFFECT (ANTIMUTAGENIC) OF DALBERGIA LATIFOLIA ON SWISS ALBINO MICE

Authors

  • Nagarathna Pkm
  • Chandrajeet Kumar Yadav
  • Saroj Kumar Yadav

Abstract

Dalbergia latifolia Roxb. (Family: Fabaceae) is a traditional herb, contain latinone and     dalcriodain flavonoid having excellence medicinal value8.

Thepresentstudy wasdesignedtoevaluatetheanti-mutagenicpotentialofMethanolic extractof Dalbergia latifolia,usingmicronucleus(MN)andchromosomalaberration(CA)assay inmice bonemarrow.Theanti-mutageniceffectofDalbergia latifoliawasassessed usingcyclophosphamideMNformationandCAinmice.Theanimalswerepre-treatedwiththe MethanolicextractofDalbergia latifoliaorallyattwodosesof100, 200mg/kgbody weightforsevendays.InMNandCAtestthetwodosesprovidedprotectionwhengiven24hrs priortoasinglei.padministrationofcyclophosphamide(100mg/kgbodyweight). Theseresults demonstrate thatMethanolic extractofDalbergia latifoliahas got anti-mutagenic potential.

Keywords: Dalbergia latifolia, Methanolic extract, anti-mutagenic activity

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Published

2015-05-01

How to Cite

Pkm, N., C. Kumar Yadav, and S. K. Yadav. “EVALUATION OF MUTAGENIC EFFECT (ANTIMUTAGENIC) OF DALBERGIA LATIFOLIA ON SWISS ALBINO MICE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 3, May 2015, pp. 154-8, https://innovareacademics.in/journals/index.php/ajpcr/article/view/5210.

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