USAGE OF SUGAR ESTER IN THE PREPARATION OF AVOCADO OIL NANOEMULSION

  • Nagib A. Elmarzugi 1- Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia. 2- Biotechnology Research Center, LARST, Tripoli, Libya and Faculty of Pharmacy, Tripoli University.
  • Ahmad M. Eid 1- Research and Innovation Dept., Institute of Bioproduct Development, Universiti Teknologi Malaysia. 81310 UTM Johor Bahru, Johor, Malaysia 2- Faculty of Medicine and Health Sciences, Department of Pharmacy, An-Najah National University, Nablus Palestine.
  • Nabil S. Elnattah Biotechnology Research Center, LARST, Tripoli, Libya and Faculty of Pharmacy, Tripoli University
  • Assad A. Elmahgoubi Biotechnology Research Center, LARST, Tripoli, Libya and Faculty of Pharmacy, Tripoli University
  • Mariani Abdul Hamid Research and Innovation Dept., Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia.
  • Rosnani Hasham Research and Innovation Dept., Institute of Bioproduct Development, Universiti Teknologi Malaysia. 81310 UTM Johor Bahru, Johor, Malaysia
  • Azila Aziz Research and Innovation Dept., Institute of Bioproduct Development, Universiti Teknologi Malaysia. 81310 UTM Johor Bahru, Johor, Malaysia
  • Farah Diana Ariffin Research and Innovation Dept., Institute of Bioproduct Development, Universiti Teknologi Malaysia. 81310 UTM Johor Bahru, Johor, Malaysia
  • Mohamed Salama Faculty of Pharmacy, Universiti Teknologi Mara, Selangor, Malaysia.

Abstract

ABSTRACT
Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology are
becoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllable
droplet size, long-term stability, and power solubilization ability. It is beneficial in various delivery systems either for transdermal, ocular, nasal,
vaginal, and parenteral drug delivery. The objective of the study was to prepare avocado oil NE using different surfactants to find the most suitable
nanosized droplets, as avocado oil offers a variety of purported nutritional and medicinal benefits.
Methods: Sucrose esters, glycerol, and avocado oil with different ratio were used to produce pre-NE by phase inversion technique then pre-NE
were self-emulsified with water to produce NE. The influence of the sucrose esters surfactants on the NE formulations were determined using three
different types of sucrose esters surfactant (laureate, oleate, and palmitate). Stability study was conducted for NE at different temperatures (4°C, 25°C,
and 40°C) for 6 months.
Results: The NE contained sucrose laureate produced best nanosized formulations compared to other oleate and palmitate, with optimum droplet
size 106 ± 1.70 nm, size distribution 0.156 ± 0.01, and zeta potential −30.4 ± 0.70. The NE formulations were very stable at 4°C compared to 25°C and
40°C while at 25°C NE showed moderate stability, but it was unstable at 40°C.
Conclusion: Sucrose laureate was able to produce NE with phase inversion and self-emulsification techniques and the ideal storage condition for NE is 4°C.
Keywords: Avocado oil, Nanoemulsions, Self-nanoemulsification, Phase inversion technique, Sucrose ester, Stability.

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How to Cite
Elmarzugi, N. A., A. M. Eid, N. S. Elnattah, A. A. Elmahgoubi, M. Abdul Hamid, R. Hasham, A. Aziz, F. D. Ariffin, and M. Salama. “USAGE OF SUGAR ESTER IN THE PREPARATION OF AVOCADO OIL NANOEMULSION”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 4, July 2015, pp. 66-69, https://innovareacademics.in/journals/index.php/ajpcr/article/view/5285.
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