A REPORT ON A POTENT ANTHELMINTIC AGENT - UNBAKED COFFEE ARABICA BEAN EXTRACTS


Jamila Rampurawala, Vedamurthy A.B, Joy Hoskeri H

Abstract


Objective: Evaluation of anthelmintic activity of Coffee arabica unbaked bean extracts.

Methods: C. arabica is most commonly found in India and possess major economic value, as is one of the common beverage consumed worldwide. Once ripe, coffee berries are picked, processed ground and brewed to create consumable coffee. During coffee processing, coffee berry pulp was produced as waste which may contain large amount of phytochemicals. Moreover, ripe coffee bean before subjecting to processing and brewing, it contains many potential secondary metabolites with various therapeutic applications. However, these potential molecules are lost during processing. Helminthes infections have devastating impact on humans from the time immemorial. Helminthes are one of the most common infectious agents mainly in developing countries. Pherithema posthuma is a commonly known helminth used as model organism, because of identical physiology with Ascaris. In this connection the anthelmintic property of Coffee arabica bean extracts were evaluated against Pherithema posthuma as an experimental helminthes model. Albendazole was used as the standard reference.

Results: Among the various concentrations of chloroform extract tested, 200 µg/ml showed efficient anthelmintic activity and among all the concentrations of ethanolic extract tested, 200 µg/ml showed significant results. This investigation revealed that chloroform extract of C. arabica proved to be significant anthelmintic activity against Pheretima posthuma when compared aqueous extract, ethanolic extract and the standard drug.

Conclusion: This investigation reports a new potent anthelmintic agent that can be used as a potent drug for the treatment of helminthes infection.

Keywords:  Coffee Arabica; Anthelmintic activity; Pheretima posthuma; Ethanolic extract; Chloroform extract.


| PDF |

References


Yashwanth K, Mayank A, Pramoditha SC, Vedamurthy AB, Krishna V, Joy HH. Manilkara zapota seed embryo extract: a potent anthelminthic agent. Asian J Pharm Clin Res 2012; 5(3): 159-161.

Satish BK, Ravindra AF. Investigation of in vitro anthelmintic activity of Thespesia lampas (Cav.). Asian J Pharm Clin Res 2009; 2(2), 69-71.

Okon ED, Ogunsusi RA, Fabiyi JP. Survey and feasibility studies on fascioliasis and parasitic gastroenteritis of ruminants in Nigeria. Federal Livestock Department of Nigeria Report, Lagos; 1980; 1-55.

Geerts S, Gryseels B. Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock. Clin Microbiol Rev 2000; 13(2): 207–222.

Sophia P. Coffee, Caffeine and Health: The Real Story. Nut Food Sci 1993; 93(1): 28-33.

Kolawole VO, Achie LN. Caffeine alters skeletal muscle contraction by opening of calcium ion channels. Current Res J Biol Sci 2011; 3(5): 521-525.

Ajaiyeoba EO, Onocha PA, Olarenwaju OT. In vitro properties of Buchholzia coriaceae and Gynandropis gynandra extract. Pharm Biol 2001; 39: 217-220.

Vigar Z. Atlas of Med Parasitology. 2nd ed.P.G. Publishing House Singapore 1984. p. 242.

Dash GK, Suresh P, Kar DM, Ganpaty S, Panda SB. Evaluation of Evolvulus alsinoides Linn. for antihelmintic and antimicrobial activities, J Nat Rem 2002; 2: 182-185.

Shivkumar YM, Kumar VL. Antihelminthic activity of latex of Calotropis procera. Pharma Biol 2003; 41: 263-265.

Tagbota S, Townson S. Antiparasitic properties of medicinal and other naturally occurring products. Adv Parasitol 2001; 50: 199-205.

Bundy DA. Immuno epidemiology of intestinal helminthic infection I: The global burden of intestinal nematode disease. Trans Royal Soc Trop Med Hyg 1994; 8: 259-261.

Chaturvedi M, Dwivedi S, Dwivedi A, Barpete PK, Sachan R. Formulation and evaluation of polyherbal anthelmintic preparation. Ethnobot Leaflet 2009; 13: 329-331.

Geert S, Dorny P. Anthelmintic resistance in helminthes of animals of man in the tropics. Bull Sea Acad Roy Sci 1995; 3: 401–423.

Coles GC. Nematode control practices and anthelmintic resistance on British sheep farms. Vet Rec 1997; 141: 91–93.

Kaushik RK, Katiyar JC, Sen AB. Studies on the mode of action of anthelmintics with Ascardia galli as a test parasite. Indian J Med Res 1974; 64: 1367-1375.

Arun KY, Temjenmongla. Anthelmintic activity of Gynura angulosa against Trichinella spiralis infections in mice. Pharmacologyonline 2006; 2: 299-306.

Lal J, Chandra S, Raviprakash V, Sabir M. In vitro anthelmintic action of some indigenous medicinal plants on Ascardia galli worms. Indian J Physiol Pharm 1976; 20: 64-68.

Mali RG, Shailaja M, Patil KS. Anthelmintic activity of root bark of Capparis spinosa. Indian J Nat Prod 2005; 21: 50-51.

Chandrashekar MB, Rajanaika, Vinayaka KS, Joy HH. Evaluation of anthelmintic and antioxidant activities of Epiprinus mallotiformis leaf extracts. Asian J Pharm Clin Res 2013; 6(4): 199-202.

Yashwanth Kumar DR, Vurivi H, Mayank A, Pramoditha SC, Vedamurthy AB, Krishna V, Joy HH. Manilkara zapota seed embryo extract: a potent anthelminthic agent. Asian J Pharm Clin Res 2012; 5(3): 159-161.




About this article

Title

A REPORT ON A POTENT ANTHELMINTIC AGENT - UNBAKED COFFEE ARABICA BEAN EXTRACTS

Date

01-11-2013

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 6 Suppl 5 (Oct-Dec) 2013 Page: 119-121

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Jamila Rampurawala

Vedamurthy A.B

Joy Hoskeri H


Article Tools


Email this article (Login required)
Email the author (Login required)

Refbacks

  • There are currently no refbacks.