A REVIEW ON RESEALED ERYTHROCYTE AS A NOVEL DRUG DELIVERY SYSTEM
Cellular carriers possess great potential and merits in various modules of drug delivery. Among such cellular carriers, erythrocytes have been found
to possess huge merits for the targeted and controlled drug delivery since they are non-immunogenic, non-toxic and their circulation can be readily
controlled and could be manipulated with reference to time. Erythrocytes mediated drug delivery has been reported with therapeutic enzymes
and antiviral agents to maximize therapeutic performance, reduce the side effects, as circulating depots for controlled drug release, drug targeting,
treatment of parasitic diseases, hepatic tumors, removal of toxic agents etc. In this review, isolation of carrier erythrocytes, methods of drug loading,
characterization parameters methods and clinical applications of resealed erythrocytes were presented.
Keywords: Resealed erythrocyte, Drug targeting, Controlled release, Carrier mediated drug delivery system.
1. Kumar A, Verma M, Jha KK. Resealed erythrocytes as a carrier for drug targeting: A review. 2010;1(2).
2. Magnani M, Laguerre M, Rossi L, Bianchi M, Ninfali P, Mangani F, et al. Acetaldehyde dehydrogenase-loaded erythrocytes as bioreactors for the removal of blood acetaldehyde. Alcohol Clin Exp Res 1989;13(6):849.
3. Erich S. Biological membranes architecture and function. In: Handbook of Biological Physics. London: Elsevier; 1995. p. 1.
4. Bhagwat RR, Vaidhya IS. Novel drug delivery systems: An overview. Int J Pharm Sci Res 2013;4(3):970.
5. Gupta A, Mishra AK, Bansal P, Kumar S, Gupta V, Singh R, et al. Cell based drug delivery system through resealed erythrocyte: A review. Int J Pharm 2010;2:23-30.
6. Tortora GJ, Grabowski SR. The cardiovascular system: The blood. In: Principles of Anatomy and Physiology. Vol. 7. New York: Harper Collins College Publishers; 1993. p. 566-90.
7. Lewis DA, Alpar HO. Therapeutic possibilities of drugs encapsulated in erythrocytes. Int J Pharm 1984;22:137-46.
8. Summer MP. Recent advances in drug delivery. Pharm J 1983;230:643-5.
9. Alvarez FJ, JordÃ¡n JA, Calleja P, Lotero LA, Olmos G, DÃez JC, et al. Cross-linking treatment of loaded erythrocytes increases delivery of encapsulated substance to macrophages. Biotechnol Appl Biochem 1998;27 Pt 2:139-43.
10. Alvarez-Figueroa MJ, Blanco-MÃ©ndez J. Transdermal delivery of methotrexate: Iontophoretic delivery from hydrogels and passive delivery from microemulsions. Int J Pharm 2001;215(1-2):57-65.
11. Tajerzadeh H, Hamidi M. Evaluation of hypotonic preswelling method for encapsulation of enalaprilat in intact human erythrocytes. Drug Dev Ind Pharm 2000;26(12):1247-57.
12. Hamidi M, Tajerzadeh H, Dehpour AR, Rouini MR, Ejtemaee-Mehr S. In vitro characterization of human intact erythrocytes loaded by enalaprilat. Drug Deliv 2001;8(4):223-30.
13. Jaitely V, Kanaujia P, Venkatesan N, Jain S, Vyas SP. Resealed erythrocytes: Drug carrier potentials and biomedical applications. Indian Drugs 1996;33:589-94.
14. Pei L, Omburo G, McGuinn WD, Petrikovics I, Dave K, Raushel FM, et al. Encapsulation of phosphotriesterase within murine erythrocytes. Toxicol Appl Pharmacol 1994;124(2):296-301.
15. DeLoach JR. Encapsulation potential of a trypanocidal drug homidium bromide in bovine carrier erythrocytes. Res Exp Med (Berl) 1985;185(5):345-53.
16. Jain S, Jain SK, Dixit VK. Erythrocytes based delivery of isoniazid: Preparation and in vitro characterization. Indian Drugs 1995;32:471-6.
17. Deloach JR, Harris RL, Ihler GM. An erythrocyte encapsulator dialyzer used in preparing large quantities of erythrocyte ghosts and encapsulation of a pesticide in erythrocyte ghosts. Anal Biochem 1980;102(1):220-7.
18. Zimmermann U, Riemann F, Pilwat G. Enzyme loading of electrically homogeneous human red blood cell ghosts prepared by dielelctric breakdown. Biochim Biophys Acta 1976;436:460-74.
19. Kinosita K Jr, Tsong TY. Formation and resealing of pores of controlled sizes in human erythrocyte membrane. Nature 1977;268:438-41.
20. Zimmermann U, Pilwat G, Riemann F. Preparation of erythrocyte ghosts by dielectric breakdown of the cell membrane. Biochem Biophys Acta 1975;375(2):209-19.
21. Tsong TY, Kinosita K Jr. Use of voltage pulses for the pore opening and drug loading, and the subsequent resealing of red blood cells. Bibl Haematol 1985;108-14.
22. Mitchell DH, James GT, Kruse CA. Bioactivity of electric field-pulsed human recombinant interleukin-2 and its encapsulation into erythrocyte carriers. Biotechnol Appl Biochem 1990;12(3):264-75.
23. Mouneimne Y, Tosi PF, Gazitt Y, Nicolau C. Electro-insertion of xeno-glycophorin into the red blood cell membrane. Biochem Biophys Res Commun 1989;159:34-40.
24. Johnson KM, Tao JZ, Kennan RP, Gore JC. Gadolinium-bearing red cells as blood pool MRI contrast agents. Magn Reson Med 1998;40(1):133-42.
25. Kennan RP, Zhong J, Gore JC. Intravascular susceptibility contrast mechanisms in tissues. Magn Reson Med 1994;31(1):9-21.
26. MillÃ¡n CG, Marinero ML, CastaÃ±eda AZ, Lanao JM. Drug, enzyme and peptide delivery using erythrocytes as carriers. J Control Release 2004;95:27-49.
Asian J Pharm Clin Res, Vol 8, Issue 4, 2015, 101-107
Selvamani et al.
27. Benatti U, Zocchi E, Tonetti M, Guida L, Polvani C, De Flora A. Enhanced antitumor activity of adriamycin by encapsulation in mouse erythrocytes targeted to liver and lungs. Pharmacol Res 1989;21 Suppl 2:27-33.
28. Antonelli A, Sfara C, Mosca L, Manuali E, Magnani M. New biomimetic constructs for improved in vivo circulation of superparamagnetic nanoparticles. J Nanosci Nanotechnol 2008;8(5):2270-8.
29. Rina K. Tumour delivery of anticancer agents via colloidal carriers constructed with P-glcoprotein inhibitory excipients. London: Kingston University; 2010.
30. Vitvitsky M. Erythrocytes as Carriers of Anthracycline Antibiotics In Vitro and In Vivo Study.
31. Magnani M, Fraternale A, Casabianca A, Schiavano GF, Chiarantini L, Palamara AT, et al. Antiretroviral effect of combined zidovudine and reduced glutathione therapy in murine AIDS. AIDS Res Hum Retroviruses 1997;13(13):1093-9.
32. Magnani M, Rossi L, Brandi G, Schiavano GF, Montroni M, Piedimonte G. Targeting antiretroviral nucleoside analogues in phosphorylated form to macrophages: in vitro and in vivo studies. Proc Natl Acad Sci U S A 1992;89(14):6477-81.
33. Hamidi M, Zarrin A, Foroozesh M, Mohammadi-Samani S. Applications of carrier erythrocytes in delivery of biopharmaceuticals. J Control Release 2007;118(2):145-60.
34. Shavi GV, Doijad RC, Deshpande PB, Manvi FV, Meka SR, Udupa N, et al. Erythrocytes as carrier for prednisolone: in vitro and in vivo evaluation. Pak J Pharm Sci 2010;23(2):194-200.
35. Lizano C, Weissig V, Torchilin VP, Sancho P, GarcÃa-PÃ©rez AI, Pinilla M. In vivo biodistribution of erythrocytes and polyethyleneglycol-phosphatidylethanolamine micelles carrying the antitumour agent dequalinium. Eur J Pharm Biopharm 2003;56(2):153-7.
36. Banz A, Cremel M, Rembert A, Godfrin Y. In situ targeting of dendritic cells by antigen-loaded red blood cells: A novel approach to cancer immunotherapy. Vaccine 2010;28(17):2965-72.
37. Zocchi E, Tonetti M, Polvani C, Guida L, Benatti U, De Flora A. In vivo liver and lung targeting of adriamycin encapsulated in glutaraldehyde-treated murine erythrocytes. Biotechnol Appl Biochem 1988;10(6):555-62.
38. Bertrand N, Leroux JC. The journey of a drug-carrier in the body: An anatomo-physiological perspective. J Control Release 2012;161:152-63.
39. Bird J, Best R, Lewis DA. The encapsulation of insulin in erythrocytes. J Pharm Pharmacol 1983;35(4):246-7.
40. Lizano C, Sanz S, Luque J, Pinilla M. In vitro study of alcohol dehydrogenase and acetaldehyde dehydrogenase encapsulated into human erythrocytes by an electroporation procedure. Biochim Biophys Acta 1998;1425:328-36.
41. Green R, Widder KJ. Methods in Enzymology. San Diego: Academic Press; 1987. p. 149.
42. Green R, Miller J, Crosby W. Enhancement of iron chelation by desferrioxamine entrapped in red blood cell ghosts. Blood 1981;57(5):866-72.
43. Guyton AC, Hall JE. Transport of Oxygen and Carbon Dioxide in the Blood and Body Fluids Textbook of Medical Physiology. Philadelphia, PA: W. B. Saunders; 1996. p. 513-23.
44. Alpar HO, Lewis DA. Therapeutic efficacy of asparaginase encapsulated. 1987.
45. Oâ€™Neil J. Controlling drug delivery for the application of extended or sustained-release drug products for parenteral administration. Chem Masterâ€™s Theses.
46. Pouliot R, Saint-Laurent A, Chypre C, Audet R, VittÃ©-Mony I, -Gaudreault RC, et al. Spectroscopic characterization of nanoc Erythrosomes in the absence and presence of conjugated polyethyleneglycols: An FTIR and (31)P-NMR study. Biochim Biophys Acta 2002;1564:317-24.
47. Verma RK, Garg S. Current status of drug delivery technologies and future directions. Pharm Technol Online 2001;25(2):1-14.
48. Staedtke V, BrÃ¤hler M, MÃ¼ller A, Georgieva R, Bauer S, Sternberg N, et al. In vitro inhibition of fungal activity by macrophage-mediated sequestration and release of encapsulated amphotericin B nanosupension in red blood cells. Small 2010;6:96-103.
49. Cuppoletti J, Mayhew E, Zobel CR, Jung CY. Erythrosomes: Large proteoliposomes derived from crosslinked human erythrocyte cytoskeletons and exogenous lipid. Proc Natl Acad Sci U S A 1981;78(5):2786-90.
50. Eichler HG, Rameis H, Bauer K, Korn A, Bacher S, Gasic S. Survival of gentamicin-loaded carrier erythrocytes in healthy human volunteers. Eur J Clin Invest 1986;16(1):39-42.
51. Field WN, Gamble MD, Lewis DA. A comparison of treatment of thyroidectomized rats with free thyroxin and thyroxin encapsulated in erythrocytes. Int J Pharm 1989;51(2):175-8.
52. GarÃn MI, LÃ³pez RM, Sanz S, Pinilla M, Luque J. Erythrocytes as carriers for recombinant human erythropoietin. Pharm Res 1996;13(6):869-74.
53. Gothoskar AV. Resealed erythrocytes: A review. Pharm Technol 2004;1:140-58.
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