STUDIES ON ANTICONVULSANT ACTIVITY OF ANNACYCLUS PYRETHRUM IN ALBINO MICE

  • Nirmala D Assistant professor, chemical engineering department, Sathyabama University.

Abstract

ABSTRACT
Objective: A study which involves in detecting anticonvulsant activity from Anacyclus pyrethrum roots by using maximal electroshock seizure (MES)
in a dose-dependent way with the production of ethanolic extraction.
Methods: The MES test is considered to be a predictor of likely therapeutic efficacy against generalized tonic-clonic seizures.
Results: MES-induced tonic seizures can be prevented either by drugs that inhibit voltage dependent Na+ channels, such as phenytoin, valproate, and
lamotrigine or by drugs that block glutamatergic excitation mediated by the N-methyl-D-aspartate receptor like felbamate.
Conclusion: The efficiency of A. pyrethrum will be detected after the incubation time of the animal, and the values of the ethanolic extraction will be
tested for the anticonvulsant activity.
Keywords: Anacyclus pyrethrum, Albino mice, Maximal electroshock seizure, Anticonvulsant activity, Drugs.

References

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How to Cite
D, N. “STUDIES ON ANTICONVULSANT ACTIVITY OF ANNACYCLUS PYRETHRUM IN ALBINO MICE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 4, July 2015, pp. 178-87, https://innovareacademics.in/journals/index.php/ajpcr/article/view/6313.
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