• Nirmala D Assistant professor, chemical engineering department, Sathyabama University.


Objective: A study which involves in detecting anticonvulsant activity from Anacyclus pyrethrum roots by using maximal electroshock seizure (MES)
in a dose-dependent way with the production of ethanolic extraction.
Methods: The MES test is considered to be a predictor of likely therapeutic efficacy against generalized tonic-clonic seizures.
Results: MES-induced tonic seizures can be prevented either by drugs that inhibit voltage dependent Na+ channels, such as phenytoin, valproate, and
lamotrigine or by drugs that block glutamatergic excitation mediated by the N-methyl-D-aspartate receptor like felbamate.
Conclusion: The efficiency of A. pyrethrum will be detected after the incubation time of the animal, and the values of the ethanolic extraction will be
tested for the anticonvulsant activity.
Keywords: Anacyclus pyrethrum, Albino mice, Maximal electroshock seizure, Anticonvulsant activity, Drugs.


1. Chauhan DK, Singh RN. Contribution of medieval India to ayurvedic materia medica. Indian J Hist Sci 1981;16(1):17-21.
2. Bentley R. Medicinal Plant. New Delhi: Omsons Publications; 2002. p. 151.
3. The Wealth of India. A Dictionary of Indian Raw Materials and Industrial Products. Vol. 9. New Delhi, India: NISCAIR; 1948. p. 250‑4.
4. Khare CP. Encyclopedia of Indian Medicinal Plants. New York: Springerverlog, Berlin, Heidelberg; 2007. p. 46-7.
5. Veeraraghvan P. Expert Consultant, CPCSEA, OECD Guideline No. 420 (Annexure-2nd) 2000.
6. Sayyah M, Valizadeh J, Kamalinejad M. Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole and maximal electroshock-induced seizures. Phytomedicine 2000;9:212-6.
7. Sayyah M, Mandgary A. Anticonvulsant effect of Ferula gummosa root extract against experimental seizures. Iran Biomed J 2003;7(3):139-43.
8. Bolton S, Bon C. Pharmaceutical Statistics. Blacksburg: Marcel Dekker Publication; 2004. p. 265.
9. Löscher W, Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res 1988;2(3):145-81.
10. Macdonald RL, Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia 1995;36 Suppl 2:S2-12.
11. Rogawski MA, Porter RJ. Antiepileptic drugs: Pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev 1990;42(2):223-86.
12. Subramaniam S, Rho JM, Penix L, Donevan SD, Fielding RP, Rogawski MA. Felbamate block of the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther 1995;273(2):878-86.
13. Mahe M, Driessche JV, Girre L. Pharmacological properties of several indigenous plants on the nervous system. Plant Med Phytother 1978;12:248-58.
14. Nadkarni KM. Indian Materia Medica. Vol. 1. Bombay, India: Popular Prakashan; 1976.
15. Rimbau V, Risco E, Canigueral S, Iglesias J. Anti-inflammatory activity of some extracts from plants used in the traditional medicine of North African countries. Farmacognesia 1995;10:150-3.
16. Bendjeddou D, Lalaoui K, Satta D. Immunostimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum,Alpinia galanga and Citrullus colocynthis. J Ethnopharmacol 2003;88(2-3):155-60.
17. Vikas S, Mayank T, Nagendra SC, Vinod KD. Evaluation of the anabolic, aphrodisiac and reproductive activity of Anacyclus pyrethrum DC in male rats. Sci Pharm 2009;77:97-110.
18. Kokate CK. Practical Pharmacognosy. New Delhi: Vallabh Prakashan; 1994. p. 107-11.
19. Ecobichon DJ. The Basis of Toxicity Testing. 2nd ed. New York: CRC Press; 1997. p. 43-60.
20. Dixit VK, Varma KC. Effects of essential oil of leaves of Blumea lacera DC on central nervous system. Indian J Pharmacol 1976;18:7-11.
21. Murugesan T, Ghosh L, Das J, Pal M, Saha BP. CNS activity of Jussiaea Suffruticosa Linn in rats and mice. J Pharm Pharm Community 1999;5:663-6.
22. Turner RA. Depressants of the central nervous system. In: Screening procedure in Pharmacology. Vol. 1. 1st ed. New York: Academic Press; 1972. p. 78-88.
23. Oztürk Y, Aydin S, Beis R, Baser KH, Berberoglu H. Effects of Hypericum perforatum L. and Hypericum calycinum L. extracts on the central nervous system in mice. Phytomedicine 1996;3(2):139-46.
24. Wolfman C, Viola H, Paladini A, Dajas F, Medina JH. Possible anxiolytic effects of chrysin, a central benzodiazepine receptors ligand isolated from Passiflora coeruiea. Pharmacol Biochem Behav 1994;47(1):1-4.
25. File SE, Pellow S. The effects of triazolobenzodiazepines in two animal tests of anxiety and in the holeboard. Br J Pharmacol 1985;86(3):729‑35.
26. Parle M, Dhingra D. Ascorbic Acid: A promising memory-enhancer in mice. J Pharmacol Sci 2003;93(2):129-35.
27. Porsolt RD, Bertin A, Jalfre M Behavioral despair in mice: A primary screening test for antidepressants. Arch Int Pharmacodyn Ther 1977;229(2):327-36.
28. Cryan JF, Markou A, Lucki I. Assessing antidepressant activity in rodents: Recent developments and future needs. Trends Pharmacol Sci 2002;23(5):238-45.
29. Muruganandam AV, Kumar V, Battacharya SK. Status report on neuropharmacology. Indian J Pharmacol 2000;32:119-33.
30. Nalini K, Karanth KS, Rao A, Aroor AR. Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats. J Ethnopharmacol 1995;47(2):101-8.
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How to Cite
D, N. “STUDIES ON ANTICONVULSANT ACTIVITY OF ANNACYCLUS PYRETHRUM IN ALBINO MICE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 4, July 2015, pp. 178-87,
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