EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF THE AERIAL PARTS OF PHYLLANTHUS RETICULATES AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN RATS

  • Swagatika Dash aInstitute of Pharmacy and Technoloy, Salipur, Odisha- 754202, India.
  • Sovan Pattanaik School of Pharmaceutical Sciences Siksha ‘O’Annusandhan University Bhubaneswar- 751003, Odisha, India.
  • Sudhanshu Sekhar Rout School of Pharmaceutical Sciences Siksha ‘O’Annusandhan University Bhubaneswar- 751003, Odisha, India.
  • Anindya Bose School of Pharmaceutical Sciences Siksha ‘O’Annusandhan University Bhubaneswar- 751003, Odisha, India.

Abstract

ABSTRACT
Objective: The present study deals with evaluation of hepatoprotective effect against paracetamol induced hepatitis in rats and in-vitro antioxidant
activity of aerial parts of ethanolic extract (70%) of Phyllanthus reticulates.
Methods: Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and total Bilirubin were tested in both treated and
untreated groups.
Results: Treatment with ethanolic extract of Phyllanthus reticulates (400 mg/kg) has brought back the altered levels of biochemical markers to the
near normal level which is comparable with the standard drug Silymarin.
Conclusion: Further the in-vitro antioxidant activity and total phenolic content showed significant result which in turn encourages further evaluation
of this plant in future.
Keywords: Phyllanthus, Hepatitis, Biochemical markers, Antioxidant activity, Total phenolic content.

References

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Table 2: Effect of ethanolic extract of P. reticulates on some biochemical parameters of paracetamol intoxicated rats
Parameters
Normal control
Paracetamol control
EATE (400 mg/kg)
Silymarin (25 mg/kg)
AST (U/L)
32.7±4.3
148.3±8.8a
58.7±6.2***
45.3±5.7***
ALT (U/L)
13.2±1.2
70.5±5.9a
24.5±2.1**
17.08±1.8**
ALP (U/L)
133.21±3.82
210.67±4.04a
157.22±2.58***
163±10.9***
Bilirubin (mg/dl)
0.10±0.04
0.44±0.07a
0.22±0.05*
0.14±0.04*
Values are mean±SEM, (n=6), ap<0.01: Paracetamol control group compared with normal control group, *p<0.01: Experimental groups compared with paracetamol control group, AST: Aspartate aminotransferase, ALT: Alanine aminotransferase, ALP: Alkaline phosphate, SEM: Standard error of mean, P. reticulates: Phyllanthus reticulatus
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Dash, S., S. Pattanaik, S. S. Rout, and A. Bose. “EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF THE AERIAL PARTS OF PHYLLANTHUS RETICULATES AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 4, July 2015, pp. 221-4, https://innovareacademics.in/journals/index.php/ajpcr/article/view/6507.
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