ANTIOXIDANT ACTIVITY AND HEPATOPROTECTIVE POTENTIAL OF BALANITES ROXBURGHII FRUITS

  • RAJANANDA SWAMY T Andhra University
  • GANGA RAO B
  • Haritha P Andhra University

Abstract

ABSTRACT
Objectives: The objective of the present study was to evaluate antioxidant activity and hepatoprotective potential of a hydroalcoholic extract of
Balanites roxburghii (BR) fruits.
Methods: Extraction was performed by triple maceration using ethanol:water as a solvent. The extracts were vaporated using rotavapor. Then
antioxidant capacities were tested using superoxide, hydroxyl, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Determination of hepatoprotective
model was performed by thiocetamide induced liver models.
Results: The hydroalcoholic extract of BR fruits produced a dose-dependent percentage inhibition on tested free radicals, i.e., superoxide anion
(50% inhibition concentrations [IC50] value 190.50 μg/ml), hydroxyl radical (IC50 value 266.30 μg/ml), and DPPH radical (IC50 value 175 μg/ml). After
treatment with silymarin and hydroalcoholic extract of BR in respective groups, they had showed good protection against thioacetamide induced liver
toxicity.
Conclusion: The results of the present investigation clearly indicate the free radical scavenging activity and hepatoprotective potential of a
hydroalcoholic extract of BR fruits and this activity is comparable with that of the standard drugs ascorbic acid and silymarin.
Keywords: Balanites roxburghii, Antioxidant activity, Hepatoprotective activity, Ascorbic acid.

References

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How to Cite
T, R. S., G. R. B, and H. P. “ANTIOXIDANT ACTIVITY AND HEPATOPROTECTIVE POTENTIAL OF BALANITES ROXBURGHII FRUITS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 4, July 2015, pp. 270-3, https://innovareacademics.in/journals/index.php/ajpcr/article/view/6647.
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