STUDY OF RATIONAL PRESCRIBING AND DISPENSING OF PRESCRIPTIONS WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN ORTHOPEDIC OUTPATIENT DEPARTMENT
Objective: To study the prescribing pattern of non-steroidal anti-inflammatory drugs (NSAIDs) in outpatient orthopedic hospitals from a rural area
of Maharashtra, India.
Methods: A total of 237 prescriptions containing NSAIDs evaluated for their distribution according to the classification of NSAIDs and World Health
Organization core indicators for prescribing practices and patient care.
Results: The average number of drugs per prescription was 3.5. The average number of NSAIDs per prescription found to be 1.12. The incidence
of generic prescribing was very low. The overall average consultation time and dispensing time found to be 4.5 and 1.9 minutes respectively.
The percentage of drugs adequately labeled was 61.44%. Out of the 843 drugs, 267 were systemic NSAIDs, of which 50.56% and 49.43% used
as monotherapy and fixed dose combinations respectively. The prescriptions are containing either one or two NSAIDs. Non-selective NSAIDs most
commonly prescribed than selective cyclooxygenase-2 (COX2) inhibitors and highly selective COX2 inhibitors. The ratio of non-selective to selective
NSAID usage pattern was 1:1.28.
Conclusion: The study shows more use of traditional NSAIDs and underutilization of COX2 inhibitors. The study suggests that there is the immense
scope of improvement for prescribing in the hospitals.
Keywords: Prescribing pattern of non-steroidal anti-inflammatory drugs, Rational use of non-steroidal anti-inflammatory drugs, World Health
Organization core drug use indicators.
2. Rahman MS, Begum ZA , Samad MK. Prescribing pattern of non-steroidal anti-inflammatory drugs at outpatient departments of teaching hospitals. Bangladesh J Pharmacol 2007; 2: 1-6.
3. Ong CKS, Lirk P, Tan Ch, Seymour RA. An Evidence-Based Update on Nonsteroidal Anti-Inflammatory Drugs. CM& R, 2007; 5: 19-34.
4. Pravin Ingle, Vibhavari Lathi, Prakash Patil, Sanjay Surana, Narendra Shirsath. Evaluation of symptomatic efficacy and safety of diclofenac versus etrocoxib in combination with serratiopeptidase in knee osteoarthritis. Genesis Journals â€“ Pharamegene.. 2014, Jan-April; 1(4): 10-14.
5. Murray CJL, Lopez AD, editors. The global burden of disease: a comprehensive assessment of mortality and disability from disease, injury and risk factors in 1990 and projected to 2020. Cambridge (MA): Harvard University Press; 1996.
6. Yuen YH, Chang S, Chong CK, Lee SC, Critchlev JA, Chan JC. Drug utilization in a hospital general medical outpatient clinic with particular reference to antihypertensive and antidiabetic drugs.
7. WHO Action Programme on Essential Drugs and Vaccines. How to investigate drug use in health facilities: selected drug use indicators. Geneva, World Health Organization, 1993. Brian S. Phamacoepidemiology. 4 th ed. British library cataloguing in publication data. John wily and sons. P. 408.
8. Frolich JC. A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. Trends Pharmacol Sci 1997; 18: 30-4.
9. Alam K, Mishra P, Prabhu M, Shankar PR, Palaian S, Bhandari RB et.al. A study on rational drug prescribing and dispensing in outpatients in a tertiary care teaching hospital of Western Nepal. Kathmandu University Medical Journal 2006; 16: 436- 43.
10. Sharif SI, Al-Shaqra M, Hajjar H, Shamout A, Wess L. Patterns of drug prescribing in a hospital in Dubai, United Arab Emirates. Libyan J Med, AOP: 070928.
11. P. V. Ingle, J. P. Aravadiya, S. D. Patil, S. J. Surana. Efficacy of Cefoperazone and Sulbactam as a Surgical Antibiotic in Hip Surgery. International Journal of Pharma & Bio sciences 2011, Jan-Mar 2(1):211-219.
12. National Essential Drug List, Drug information center, Maharashtra State Pharmacy Council 2008.
13. S. Otoom, A. Batieha, H. Hadidi, M. Hasan, K. Al-Saudi. Evaluation of drug use in Jordan using WHO prescribing indicators. Eastern Mediterranean Health Journal 2002; 8 (4 & 5).
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.