ANTICONVULSANT PROPERTY OF SYNTHESIZED COMPOUND DHPM-5 IN LABORATORY ANIMALS

  • Ashutosh Kumar Yadav Asst. Prof. Department of pharmacology School of Pharmacy BBD University Lucknow 226028
  • Prabhat Upadhyay Research scholar
  • Dharamveer Panjwani Asst. Prof.
  • Narsigh Sachan Drug Analyst

Abstract

Objective: The present study was undertaken to investigate the anti-convulsant effects of dihydropyrimidinone-5 (DHPM-5) in animal models.
Materials and Methods: Swiss albino mice were used for the study. The test drug and standard drugs were administered once daily for a period of
14 days. Maximal electroshock (MES) induced convulsion and strychnine induced convulsion models were used for the study. Phenytoin (PHT) and
Diazepam were used as standard agents throughout the study.
Results and Discussion: Anti-convulsant studies with test drug showed a significant protection in MES induced convulsion models in a dosedependent
manner.
There
was
a significant
(p<0.05)
decrease
in the duration
of
tonic
hind limb extension
at both
the
doses of
test
drug (200
mg/kg)

in
MES
model. Compared
with
the control
group,
treatment
with
test
drug
had no
significant effect
on onset and
duration
of convulsions
in
the
strychnine
induced
seizure
model. As expected,
the animals treated
with diazepam
4
mg/kg
increased
onset,
duration
of
convulsions
and latency
to

death
as compared
with control
group.
In all groups,
all animals
had
seizures
and all died.
DHPM-5
has
an influence on the excitatory
and
inhibitory

neurotransmission,
of special interest
being the increase
in the gamma
amino butyric acid levels.
Conclusion: The presence of the chemical constituents gave strength to its anti-convulsant action. However, further research is warranted to
determine the specific mode of its anti-convulsant activity.
Keywords: Dihydropyrimidinone-5, Strychnine, Seizure, Neurotoxicity.

Author Biographies

Ashutosh Kumar Yadav, Asst. Prof. Department of pharmacology School of Pharmacy BBD University Lucknow 226028

Department of Pharmacology

Asst. Prof.

Prabhat Upadhyay, Research scholar
Pharmacology
Dharamveer Panjwani, Asst. Prof.
Pharmacology
Narsigh Sachan, Drug Analyst
Govertment Sector

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How to Cite
Yadav, A. K., P. Upadhyay, D. Panjwani, and N. Sachan. “ANTICONVULSANT PROPERTY OF SYNTHESIZED COMPOUND DHPM-5 IN LABORATORY ANIMALS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 5, Sept. 2015, pp. 139-42, https://innovareacademics.in/journals/index.php/ajpcr/article/view/7017.
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