INHIBITORY EFFECT OF ETHANOLIC ROOT EXTRACT OF COIX LACHRYMAJOBI ON HYALURONIDASE AND L-AMINO ACID OXIDASE OF NAJA NAJA AND DABOIA RUSSELLI VENOM

  • C. Vaman Rao
  • Rajesh Ks
  • Ishwara Bhat K

Abstract

Objective: This study was carried out to investigate the efficacy of inhibitory effect of ethanolic root extract (ERE) of plant Coix lachrymajobi (Poaceae) on hyaluronidase and L-amino acid oxidase (LAAO) of Daboia russelii and Naja naja venom. 

Methodology: The ethanolic root extract of C. lachrymajobi is used to treat snake bite victims by traditional healers as folk medicine for centuries, was tested in-vitro to determine its ability to inhibit D. russelli and N. naja hyaluronidase and LAAO activities.  In-vitro studies were carried out with different doses of ERE.

Results & Discussion: which effectively neutralized hyaluronidase and LAAO activities of both D. russelli and N. naja venom.  ERE at doses of 2000µg successfully inhibited D. russelli (50 µg) hyaluronidase activity by 67.04% and LAAO activity by 77.86%.  The hyaluronidase activity of N. naja venom (50 µg) was inhibited by 71.83% and LAAO activity was reduced by 74.83%.  From the results, It is evident that the ERE of Coix lachrymajobi effectively neutralizes important toxic enzymes of the D. russelli and Naja naja venoms.

Keywords: Daboia russelii; Naja naja; Coix lacryma-jobi; Hyaluronidase; L-amino acid oxidase

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How to Cite
Rao, C. V., R. Ks, and I. B. K. “INHIBITORY EFFECT OF ETHANOLIC ROOT EXTRACT OF COIX LACHRYMAJOBI ON HYALURONIDASE AND L-AMINO ACID OXIDASE OF NAJA NAJA AND DABOIA RUSSELLI VENOM”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 5, Sept. 2015, pp. 206-8, https://innovareacademics.in/journals/index.php/ajpcr/article/view/7320.
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