ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF EUGENIA POLYANTHA WIGHT LEAF FROM INDONESIA IN DIABETIC RAT WISTAR STRAIN INDUCED BY ALLOXAN

  • Em Sutrisna Department of Pharmacology of Universitas Muhammadiyah Surakarta. Indonesia

Abstract

Objective: The purpose of this study is to determine the antidiabetic activity of 96% ethanolic extract of Eugenia polyantha wight leaves.

Methods: Twenty-five male Wistar rats were divided into 5 groups. Group I was negative control (aquabidest),group II was positive control (Glibenclamide 0.45 mg/kg), group III, IV, and V were treated by the 96% ethanolic extract of leaves of Eugenia polyantha wight with doses of 312,5; 625; and 1250 mg/kg respectively. Before the treatment, All rats were induced by  alloxan with dose of 150 mg / kg by intra peritoneal. On 3rd day after induction, rats with blood glucose level> 200 mg/dL were treated by drugs or extract appropriate to the group. On 10th day, after blood sampling, all rats were killed and the pancreas were taken for histophatology examination. The blood glucose level on 10th day was tested by  Kruskall- Wallis test followed by the Mann-Whitney with confidence level  95%.

Results:  The 96% ethanolic extract of leaves of Eugenia polyantha wight at doses of 312.5 mg/kg, 625 mg/kg and 1250 mg/kg body weight can reduce blood glucose levels in rat induced by alloxan. The 96% ethanolic extract of Eugenia polyantha wight at dose of 1250 mg/kg body weight potentially regenerate Langerhans  cell  induced by alloxan. This extract has potentials as antidiabetic agent

Conclusion: This study shows that the 96% ethanolic extract of  Eugenia polyantha wight can be developed as an antidiabetic agent

Author Biography

Em Sutrisna, Department of Pharmacology of Universitas Muhammadiyah Surakarta. Indonesia
Department of Pharmacology, Faculty of Medicine of Universitas Muhammadiyah Surakarta, Indonesia
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How to Cite
Sutrisna, E. “ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF EUGENIA POLYANTHA WIGHT LEAF FROM INDONESIA IN DIABETIC RAT WISTAR STRAIN INDUCED BY ALLOXAN”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 374-6, https://innovareacademics.in/journals/index.php/ajpcr/article/view/7995.
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