ANTIMICROBIAL UTILIZATION PATTERN OF URINARY TRACT INFECTION IN TERTIARY CARE HOSPITAL

  • Sunil Shivaputrayya Gidamudi BKL WALAWALKAR RURAL MEDICAL COLLEGE, KASARWADI, SAWARDE, DIST: RATNAGIRI, MAHARASHTRA, INDIA.
  • Sujata A Jadhav
  • Chitra C Khanwelkar
  • Vandana M Thorat
  • Rohit R Desai
  • Harish G Naik

Abstract

Objective: To study and analyze the pattern of antimicrobial utilization in urinary tract infection (UTI).
Methods: A descriptive retrospective study was conducted in tertiary care hospital for 6 months including both male and female patients of all age
groups. Case sheets diagnosed with UTI based on ICD-10 disease coding were collected from medical records department. The demographic data
and prescription pattern of each case sheet were evaluated in detail. Drug utilization pattern was compared among different age groups of patients.
Results: A total of 108 patients were included in the study, out of which 44.4% were males, and 55.6% were females. Most of the patients were in
40-60 years age group (40.7%). UTI confirmed by culture in 59.26% patients; in which Escherichia coli was isolated in 35.9% patients followed
by Klebsiella species (14.06%) and Pseudomonas aeruginosa (7.8%). Cephalosporins (70.37%) were most commonly used antibiotic followed by
fluoroquinolones (38.89%), penicillins (29.63%), azithromycin (17.59%), and aminoglycosides (15.74%). Among the cephalosporins, third generation
parenteral was most commonly used. In penicillins, amoxicillin + clavulanic acid combination was used in 9 patients. Amikacin was most commonly
used aminoglycoside followed by gentamicin. Mean duration of treatment was 6.28±3.02 days.
Conclusion: Third generation cephalosporins (ceftriaxone and cefixime) were used as first line drug in most of the cases irrespective of the causative
organism. This group should be reserved for complicated UTIs.
Keywords: Urinary tract infections, Escherichia coli, Cephalosporins, Fluoroquinolones.

Author Biography

Sunil Shivaputrayya Gidamudi, BKL WALAWALKAR RURAL MEDICAL COLLEGE, KASARWADI, SAWARDE, DIST: RATNAGIRI, MAHARASHTRA, INDIA.

ASSISTANT PROFESSOR,

DEPARTMENT OF PHARMACOLOGY.

 

References

. Hogarth J. Glossary of Health Care Terminology. Copenhagen:
Regional Office for Europe, World Health Organization; 1978. p. 313.
2. Vijayakumar T, Sathyavati D, Subhashini T, Sonika G, Dhanaraju M.
Assessment of prescribing trends and rationality of drug prescribing.
Int J Pharmacol 2011;7(1):140-3.
3. Hcl H. A clinico-pharmacological study of out-patient prescribing
pattern of dermatological drugs in an Indian tertiary hospital. Indian J
Pharmacol 2000;32:384-5.
4. Shankar RP, Roy S, Shenoy N. Patterns of prescription and drug use in
a psychiatry out-patient department in a teaching hospital in western
Nepal. Internet J Pharmacol 2002;1(2):41.
5. Hemminki E, Ghodse H, Khan I. Factors influencing prescribing.
Psychoactive Drugs: Improving Prescribing Practices. Geneva: World
Health Organization; 1988. p. 22-35.
163
Asian J Pharm Clin Res, Vol 8, Issue 6, 2015, 161-164
Gidamudi et al.
6. Pradhan S, Shewade D, Shashindran C, Bapna J. Drug utilization
studies. Natl Med J India 1988;1:185-9.
7. Soumerai SB. Factors influencing prescribing. Aust J Hosp Pharm
1988;18(3):9-16.
8. Goel R, Bhati Y, Dutt H, Chopra V. Prescribing pattern of drugs in the
outpatient department of a tertiary care teaching hospital in Ghaziabad,
Uttar Pradesh. J Appl Pharm Sci 2013;3:S48-51.
9. Ahmed SM, Swedlund SK. Evaluation and treatment of urinary tract
infections in children. Am Fam Physician 1998;57(7):1573-80, 1583-4.
10. Arul K, Prakasam K, Kumar D, Vijayan M. A cross sectional study
on distribution of urinary tract infection and their antibiotic utilization
pattern in Kerala. Int J Res Pharm Biomed Sci 2012;3(3):1125-30.
11. Alós JI. Epidemiology and etiology of urinary tract infections in the
community. Antimicrobial susceptibility of the main pathogens and
clinical significance of resistance. Enferm Infecc Microbiol Clin
2005;23 Suppl 4:3-8.
12. Chedi B, Wannang N, Halliru M, Bichi L. Seven months retrospective
study on urinary tract infection among patients at Aminu Kano Teaching
Hospital, Kano-Nigeria. Bayero J Pure Appl Sci 2009;2(2):95-8.
13. Schlager TA. Urinary tract infections in children younger than 5 years
of age: Epidemiology, diagnosis, treatment, outcomes and prevention.
Paediatr Drugs 2001;3(3):219-27.
14. Mahesh E, Ramesh D, Indumathi V, Punith K, Raj K, Anupama H.
Complicated urinary tract infection in a tertiary care center in South
India. Al Ameen J Med Sci 2010;3(2):120-7.
15. Pargavi B, Mekala T, Thamarai Selvi M. Prevalence of urinary tract
infection (UTI) among diabetics patients in Vandavasi, Tamil Nadu,
India. Int J Biol Technol 2011;2(2):42-5.
16. Qureshi AM. Clinical presentation of urinary tract infection among
children at Ayub Teaching Hospital, Abbottabad. J Ayub Med Coll
Abbottabad 2005;17(2):79-81.
17. Mohan J, Gopal KM, Meganathan M, Sasikala P, Gowdhaman N,
Balamurugan K, et al. A study on utilization pattern of antibiotics for
the complicated urinary tract infections in a tertiary care centre. Glob J
Pharmacol 2011;5:1-3.
18. Edson RS, Terrell CL. The aminoglycosides. Mayo Clin Proc
1999;74(5):519-28.
19. Bay AG, Anacleto F Jr. Clinical and laboratory profile of urinary tract
infection among children at the outpatient clinic of a tertiary hospital.
PIDSP J 2010;11(1):10-6.
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How to Cite
Gidamudi, S. S., S. A. Jadhav, C. C. Khanwelkar, V. M. Thorat, R. R. Desai, and H. G. Naik. “ANTIMICROBIAL UTILIZATION PATTERN OF URINARY TRACT INFECTION IN TERTIARY CARE HOSPITAL”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, no. 6, Nov. 2015, pp. 161-4, https://innovareacademics.in/journals/index.php/ajpcr/article/view/8093.
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