ALOE VERA ATTENUATES GENTAMICIN-INDUCED NEPHROTOXICITY IN WISTAR ALBINO RATS: HISTOPATHOLOGICAL AND BIOCHEMICAL CHANGES

  • Shalini Virani Maharaja Agarsen Medical College, Agroha
  • Shaily Bhatt Department of Pharmacology LLRM Medical College, Meeut
  • Manish Saini Department of Pharmacology LLRM Medical College, Meeut
  • Kk Saxena Department of Pharmacology LLRM Medical College, Meeut

Abstract

Objectives: To evaluate the nephroprotective properties of ethanol extract of leaves of Aloe vera against gentamicin-induced nephrotoxicity in rats.
Methods: Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 40 mg/kg/days for 5 days. Effect of concurrent
administration of ethanol extract of leaves of A. vera at a dose of 20 ml/kg/day given by oral route was determined using serum creatinine and blood
urea nitrogen as biochemical indicators of renal damage; after 10, 20, and 30 days. The study included a control group which received oral saline only,
gentamicin treated group, received gentamicin and oral saline and A. vera group, received oral A. vera prior to gentamicin administration. Each group
had six rats.
Results: It was observed that in A. vera treated rats, prevented elevation of the biochemical indicators of nephrotoxicity and significantly reduced
histopathological scores.
Conclusion: Ethanol extract of A. vera contains constituents with nephroprotective activities.
Keywords: Gentamicin-induced nephrotoxicity, Aloe vera, Wister rats, Histopathological change.

Author Biography

Shalini Virani, Maharaja Agarsen Medical College, Agroha

Assistant Professor

Department of Pharmacology

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How to Cite
Virani, S., S. Bhatt, M. Saini, and K. Saxena. “ALOE VERA ATTENUATES GENTAMICIN-INDUCED NEPHROTOXICITY IN WISTAR ALBINO RATS: HISTOPATHOLOGICAL AND BIOCHEMICAL CHANGES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 113-7, https://innovareacademics.in/journals/index.php/ajpcr/article/view/8237.
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