• RAJASEKARAN S Jamia salafiya pharmacy college, pulikkal, malappuram(dt) kerala
  • Anandan R


Objective: Acalypha communis is a synonym of Ricinocarpus communis (Müll.Arg.) belonging to the family of Euphorbiaceae. A. communis possess a
wide variety of activities like antimicrobial. Hence, the present study was intended to evaluate ethanolic leaf extract of A. communis for hepatoprotective
Methods: The hepatoprotective activity was studied by paracetamol (2 g/kg) and D-galactosamine (400 mg/kg) induced models. Acute toxicity study
and preliminary phytochemical screening were also studied to evaluate the toxicity.
Results: No toxicity profile was observed in rats after oral administration of the ethanolic leaf extract at the dose of 5 g/kg body weight. The
different dose of 200 mg/kg and 400 mg/kg administered with the extract of A. communis. There was significant (p<0.001) reduction in biochemical
parameters with respect to control. Phytochemical screening of the plant extract revealed the presence of tannins, alkaloids, flavonoids and saponins,
and terpenoids.
Conclusion: It can be concluded that the hepatoprotective activity elucidated by A. communis could be mainly due to the presences of high-value class
of compound like the phenolic group as the major content in the plants.
Keywords: Acalypha communis, Paracetamol, D-galactosamine, Biochemical parameters and histopathological studies.


1. Sandhu DS, Heinrich M. The use of health foods, spices and
other botanicals in the Sikh community in London. Phytother Res
2. Gupta MP, Solís PN, Calderón AI, Guionneau-Sinclair F, Correa M,
Galdames C, et al. Medical ethnobotany of the Teribes of Bocas del
Toro, Panama. J Ethnopharmacol 2005;96(3):389-401.
3. Hayden WJ, Hayden SM. Wood anatomy of Acalyphoideae
(Euphorbiaceae). IAWA Bull 2000;21:213-35.
4. Kokate CK. In: Practical Pharmacognosy, Preliminary Phytochemical
Screening. 1
ed. New Delhi: Vallabh Prakashan; 1986. p. 111.
5. Darbar S, Bose A, Chatterjee N, Roy B, Chattaraj TK, Pal TK. Antioxidant
and hepatoprotective activity of ascorbic acid against diclofenac
induced hepatotoxicity in rats. Indian Drugs 2009;46(8):35-41.
6. Mao SA, Glorioso JM, Nyberg SL. Liver regeneration. Transl Res
7. Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB.
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
J Pharmacol Exp Ther 1973;187(1):185-94.
8. Udem SC, Madubunyy I, Okoye JO, Anika SM. Anti-hepatotoxic
effects of the ethanolic extracts of Combretum dolichopetalum root
bark and Morinda lucida leaf. Fitoterapia. 1997;68:21-6.
9. Langeswaran K, Jagadessan AJ, Vijayaprakash S, Balasubramanian MP.
Hepatoprotective and antioxidant activity of Scoparia dulcis Linn,
against N-nitrosodiethylamine (DEN) induced hepatotoxicity in
experimental rats. Int J Drug Dev Res 2012;4:295-303.
10. Chaudhary CD, Kamboj P, Singh I, Kalia AN. Herbs as liver savers a
review. Indian J Nat Prod Res 2010;1:397-408.
11. Jaishree V, Badami S. Antioxidant and hepatoprotective effect of
swertiamarin from Enicostemma axillare against D-galactosamine
induced acute liver damage in rats. J Ethnopharmacol 2010;130(1):103-6.
12. Chaung SS, Lin CC, Lin J, Yu KH, Hsu YF, Yen MH. The hepatoprotective
effects of Limonium sinense against carbon tetrachloride and beta-Dgalactosamine
intoxication in rats. Phytother Res 2003;17(7):784-91.
13. Nakagiri R, Hashizume E, Kayahashi S, Sakai Y, Kamiya T. Suppression
by Hydrangeae Dulcis Folium of D-galactosamine-induced liver injury
in vitro and in vivo. Biosci Biotechnol Biochem 2003;67(12):2641-3.
14. Tang XH, Gao L, Gao J, Fan YM, Xu LZ, Zhao XN, et al. Mechanisms of
hepatoprotection of Terminalia catappa L. extract on D-galactosamineinduced
liver damage. Am
J Chin Med 2004;32(4):509-19.
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How to Cite
S, R., and A. R. “PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ACALYPHA COMMUNIS MULL. ARG. FOR THEIR HEPATOPROTECTIVE ACTIVITY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 94-97,
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