PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ACALYPHA COMMUNIS MULL. ARG. FOR THEIR HEPATOPROTECTIVE ACTIVITY
Objective: Acalypha communis is a synonym of Ricinocarpus communis (MÃ¼ll.Arg.) belonging to the family of Euphorbiaceae. A. communis possess a
wide variety of activities like antimicrobial. Hence, the present study was intended to evaluate ethanolic leaf extract of A. communis for hepatoprotective
Methods: The hepatoprotective activity was studied by paracetamol (2 g/kg) and D-galactosamine (400 mg/kg) induced models. Acute toxicity study
and preliminary phytochemical screening were also studied to evaluate the toxicity.
Results: No toxicity profile was observed in rats after oral administration of the ethanolic leaf extract at the dose of 5 g/kg body weight. The
different dose of 200 mg/kg and 400 mg/kg administered with the extract of A. communis. There was significant (p<0.001) reduction in biochemical
parameters with respect to control. Phytochemical screening of the plant extract revealed the presence of tannins, alkaloids, flavonoids and saponins,
Conclusion: It can be concluded that the hepatoprotective activity elucidated by A. communis could be mainly due to the presences of high-value class
of compound like the phenolic group as the major content in the plants.
Keywords: Acalypha communis, Paracetamol, D-galactosamine, Biochemical parameters and histopathological studies.
other botanicals in the Sikh community in London. Phytother Res
2. Gupta MP, SolÃs PN, CalderÃ³n AI, Guionneau-Sinclair F, Correa M,
Galdames C, et al. Medical ethnobotany of the Teribes of Bocas del
Toro, Panama. J Ethnopharmacol 2005;96(3):389-401.
3. Hayden WJ, Hayden SM. Wood anatomy of Acalyphoideae
(Euphorbiaceae). IAWA Bull 2000;21:213-35.
4. Kokate CK. In: Practical Pharmacognosy, Preliminary Phytochemical
ed. New Delhi: Vallabh Prakashan; 1986. p. 111.
5. Darbar S, Bose A, Chatterjee N, Roy B, Chattaraj TK, Pal TK. Antioxidant
and hepatoprotective activity of ascorbic acid against diclofenac
induced hepatotoxicity in rats. Indian Drugs 2009;46(8):35-41.
6. Mao SA, Glorioso JM, Nyberg SL. Liver regeneration. Transl Res
7. Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB.
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
J Pharmacol Exp Ther 1973;187(1):185-94.
8. Udem SC, Madubunyy I, Okoye JO, Anika SM. Anti-hepatotoxic
effects of the ethanolic extracts of Combretum dolichopetalum root
bark and Morinda lucida leaf. Fitoterapia. 1997;68:21-6.
9. Langeswaran K, Jagadessan AJ, Vijayaprakash S, Balasubramanian MP.
Hepatoprotective and antioxidant activity of Scoparia dulcis Linn,
against N-nitrosodiethylamine (DEN) induced hepatotoxicity in
experimental rats. Int J Drug Dev Res 2012;4:295-303.
10. Chaudhary CD, Kamboj P, Singh I, Kalia AN. Herbs as liver savers a
review. Indian J Nat Prod Res 2010;1:397-408.
11. Jaishree V, Badami S. Antioxidant and hepatoprotective effect of
swertiamarin from Enicostemma axillare against D-galactosamine
induced acute liver damage in rats. J Ethnopharmacol 2010;130(1):103-6.
12. Chaung SS, Lin CC, Lin J, Yu KH, Hsu YF, Yen MH. The hepatoprotective
effects of Limonium sinense against carbon tetrachloride and beta-Dgalactosamine
intoxication in rats. Phytother Res 2003;17(7):784-91.
13. Nakagiri R, Hashizume E, Kayahashi S, Sakai Y, Kamiya T. Suppression
by Hydrangeae Dulcis Folium of D-galactosamine-induced liver injury
in vitro and in vivo. Biosci Biotechnol Biochem 2003;67(12):2641-3.
14. Tang XH, Gao L, Gao J, Fan YM, Xu LZ, Zhao XN, et al. Mechanisms of
hepatoprotection of Terminalia catappa L. extract on D-galactosamineinduced
liver damage. Am
J Chin Med 2004;32(4):509-19.
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