PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ACALYPHA COMMUNIS MULL. ARG. FOR THEIR HEPATOPROTECTIVE ACTIVITY
Abstract
Objective: Acalypha communis is a synonym of Ricinocarpus communis (Müll.Arg.) belonging to the family of Euphorbiaceae. A. communis possess a
wide variety of activities like antimicrobial. Hence, the present study was intended to evaluate ethanolic leaf extract of A. communis for hepatoprotective
activities.
Methods: The hepatoprotective activity was studied by paracetamol (2 g/kg) and D-galactosamine (400 mg/kg) induced models. Acute toxicity study
and preliminary phytochemical screening were also studied to evaluate the toxicity.
Results: No toxicity profile was observed in rats after oral administration of the ethanolic leaf extract at the dose of 5 g/kg body weight. The
different dose of 200 mg/kg and 400 mg/kg administered with the extract of A. communis. There was significant (p<0.001) reduction in biochemical
parameters with respect to control. Phytochemical screening of the plant extract revealed the presence of tannins, alkaloids, flavonoids and saponins,
and terpenoids.
Conclusion: It can be concluded that the hepatoprotective activity elucidated by A. communis could be mainly due to the presences of high-value class
of compound like the phenolic group as the major content in the plants.
Keywords: Acalypha communis, Paracetamol, D-galactosamine, Biochemical parameters and histopathological studies.
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