AN OUTLOOK ON THE MECHANISMS OF DRUG INTERACTIONS WITH OTHER DRUGS, FRUITS, HERBS AND THEIR PREVENTIVE MEASURES

  • ASHA K Rajan
  • Kousalya K
  • Senthil Nathan B
  • Valentina P

Abstract

Drugs taken by a person are affected by a number of ways. A number of interactions are known to affect the drugs, change its efficacy or result in
toxicity. Habits of a common person could also cause such interactions. Most of the people have habits of smoking, consumption of alcohol and taking
dietary supplements without the advice of their physicians. Some drug interactions such as those between drug-herbs and drug-citrus fruit would
bring us shock; even small fruit could sometimes bring adverse drug reactions to occur in our body. Due to drug interactions, there would sometimes
be an increase or decrease in the efficacy of a drug. Being a pharmacist, it would be their ultimate role to check at a person's hygienic record, looking
and gathering information of the past recorded drugs, dietary supplements, hereditary diseases, etc. They would have to gather information about
the recently releasing drugs and know complete information on the reactions which occur on their administration. Knowledge to people about herbal
and food-drug interactions is very less. They take them to be natural and do not care about its consequences. However, this interaction depends on the
amount and the potency of pharmacologically active ingredient present in the compounds. These herbal drugs are known to contain a varying number
of phytochemicals which may cause a change to the transporters, enzymatic systems, causing failure of the therapeutic effect of the drug interactions.
The elimination of some particular drugs is also affected due to these interactions. As a result of this interaction, a number of drugs which had taken
birth had quickly been removed from the US markets. Thus, the ways for a person to avoid these interactions can only be the above mentioned
advices given by the health practitioners, not to administer drugs by self-medication methods, taking a note of all the additional supplements taken
by a patient to his physician, so that there is a clear picture about the interactions at their initial stage. (1) There are various drug interactions with a
number of factors. (2) Unless there is clear knowledge about the pathway of drug elimination, drug interaction stands to be very difficult to be avoided.
Keywords: Drug-food interactions, Pharmacokinetic, Pharmacodynamic, Drug-drug interactions.

 

References

1. Rowland M, Tozer TN. Clinical Pharmacokinetics and
Pharmacodynamics: Concepts and Applications. 4
ed. Philadelphia:
Lippincott William and Wilkins; 2011.
th
2. Brahmankar DM, Jaishwal SB. Basic considerations. In:
Biopharmaceutics and Pharmacokinetics: A Treatise. 2
ed. New Delhi:
Vallabh Prakashan; 2009.
nd
3. Narayanan N, Balasubramanian S. Hospital and Clinical Pharmacy.
1
ed. Hyderabad: Pharma Med Press; 2013.
4. Ismail MY. Drug food interactions and role of pharmacist. Asian J
st
Pharm Clin Res 2009;2(4):1-10.
5. Wanwimolruk S, Phopin K, Prachayasittikul V. Cytochrome P450
enzyme mediated herbal drug interactions (Part 2). EXCLI J
2014;13:869-96.
6. Yaheya M, Ismail M. Herb drug interactions and patient counseling. Int
J Pharm Pharm Sci 2009;1(1):151-7.
7. Anke J, Ramzan I. Pharmacokinetic and pharmacodynamic drug
interactions with Kava (Piper methysticum Forst. f.). J Ethnopharmacol
2004;93(2-3):153-60.
8. Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drugcitrus
fruit and other food interactions: What
have we learned? J
Clin
Pharmacol
2004;44(6):559-69.
9. Nidhi S. Concept of drug interaction. Int Res J Pharm 2012;3(7):120-2.
10. Midlav P. Pharmacokinetics and pharmacodynamics in the elderly. OA
Elder Med 2013;1(1):1-5.
11. Adverse Drug-Drug and Drug Food Medication Interactions. The Ohio
Department of Ageing, the Ageing Network, Department of Agriculture
and County Commissioners Cooperating (Seniors Series); 2008.
12. Wan-Chih T. Alcohol-related drug interactions. Pharm Lett Prescr Lett
2008;24:240106.
13. Gibaldi M. Biopharmaceutics and clinical pharmacokinetics. 4
ed.
reprint. Laurier Books Limited;2005.
14. Rodríguez-Fragoso L, Martínez-Arismendi JL, Orozco-Bustos D,
Reyes-Esparza J, Torres E, Burchiel SW. Potential risks resulting
from fruit/vegetable-drug interactions: Effects on drug-metabolizing
enzymes and drug transporters. J Food Sci 2011;76:R112-24.
15. Medicines Information Centre, Pharmacy Department, Smoking and
Drug Interactions, Mersey Care NHS Trust. June 2007. http://www.
merseycare.nhs.uk/Library/What_we_do/Clinical_Services/Public_
Health/Smoking_Interactions.pdf.
16. Lindsey WT, Stewart D, Childress D. Drug interactions between
common illicit drugs and prescription therapies. Am J Drug Alcohol
Abuse 2012;38:334-43.
17. Niewstraten C, Alolbroob A, Labiris NR. Systematic review of
drug interactions with antidepressant medications Can J Psychiatry
2006;51(5):1-17.
18. Kashuba ADM, Bertino Jr JS. Mechanisms of drug interactions I:
Absorption, metabolism and excretion. In: Piscitelli SC, Rodvold KA,
editors. Drug Interactions in Infectious Diseases. Totowa, NJ: Human
Press; 2005. p. 13-39.
19. Percha B, Garten Y, Altman RB. Discovery and explanation of drugdrug
interactions via text mining. Pac Symp Biocomput 2012:410-21.
20. Synder BD, Polosek TM, Doogue MP. Drug interactions: Principles and
practice. Aust Prescr 2012;35(3):85-8.
Statistics
441 Views | 465 Downloads
How to Cite
Rajan, A. K., K. K, S. Nathan B, and V. P. “AN OUTLOOK ON THE MECHANISMS OF DRUG INTERACTIONS WITH OTHER DRUGS, FRUITS, HERBS AND THEIR PREVENTIVE MEASURES”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 10-18, https://innovareacademics.in/journals/index.php/ajpcr/article/view/8515.
Section
Review Article(s)