ANTI-PYRETIC ACTION OF Caulerpa lentillifera, Hibiscus rosa-sinensis AND Piper sarmentosum AQUEOUS EXTRACT IN MICE

  • Dzulsuhaimi Daud Universiti Teknologi MARA
  • Nur Fazuliana Mohd Arsad Universiti Teknologi MARA
  • Asmida Ismail Universiti Teknologi MARA
  • Alene Tawang Universiti Pendidikan Sultan Idris


Objective: The present study was conducted to evaluate the anti-pyretic activity of Caulerpa lentillifera, Hibiscus rosa-sinensis, and Piper sarmentosum
aqueous extracts.
Methods: The suspension of yeast was injected intraperitoneally (0.1 g/kg of bodyweight [BWT]) to induce fever in experimental animals. Rectal
temperature was recorded every hour with a lubricated digital thermometer and animals with at least 0.7°C elevations in body core temperature
were included in the experiment. The animals with fever were administered orally with aqueous extracts of C. lentillifera, H. rosa-sinensis, and
P. sarmentosum (500 mg/kg of BWT). Another group was given the commercial drug, acetaminophen (10 mg/kg of BWT), to serve as a control.
Results: The result of the study showed that C. lentillifera and H. rosa-sinensis aqueous extracts significantly (p<0.05) effective in combating fever.
However, P. sarmentosum aqueous extract has no potential as an anti-pyretic agent.
Conclusion: H. rosa-sinensis and C. lentillifera aqueous extracts have anti-pyretic potential but not P. sarmentosum aqueous extract.
Keywords: Caulerpa lentillifera, Hibiscus rosa-sinensis, Piper sarmentosum, Anti-pyretic, Fever, Pyrexia, Yeast.


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How to Cite
Daud, D., N. F. Mohd Arsad, A. Ismail, and A. Tawang. “ANTI-PYRETIC ACTION OF Caulerpa Lentillifera, Hibiscus Rosa-Sinensis AND Piper Sarmentosum AQUEOUS EXTRACT IN MICE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 167-70,
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