• Preeti Chaudhary Translam Institute of Pharmaceutical Education & Research, Meerut
  • Shamim Ahmad
  • Najam Ali Khan


Liver diseases have become one of the major causes of morbidity and mortality all over the world. From among, drug-induced liver injury is one of
the most common causative factors that possess a major clinical and regulatory challenge. Herbal plants have been used traditionally by herbalist
worldwide for the prevention and treatment of liver disease. Herbal medicines have recently attracted much attention as alternative medicines useful
for treating or preventing lifestyle related disorders and relatively very little knowledge is available about their mode of action. There has been a
growing interest in the analysis of plant products which has stimulated intense research on their potential health benefits. Allopathic drugs cause
toxicity to the liver by elevating the levels of various biomarkers present in the liver. At present, no single allopathic drug is available in the market for
liver damage. Only Liv.52 and silymarin are herbal medicine for this purpose, so herbal drugs have a strong potential in the treatment of liver diseases.
The herbal market, in the recent times, is growing day by day and is accepted at the global level. The present review focused on different herbal plants
that have been tested for hepatotoxicity in different animal models.
Keywords: Hepatoprotective activity, Liver, Hepatotoxicity, Serum enzymes, Silymarin, Liv.52, Herbal plants.

Author Biography

Preeti Chaudhary, Translam Institute of Pharmaceutical Education & Research, Meerut


Assistant Professor


1. Osadebe PO, Okoye FB, Uzor PF, Nnamani NR, Adiele IE, Obiano NC.
Phytochemical analysis, hepatoprotective and antioxidant activity of
Alchornea cordifolia methanol leaf extract on carbon tetrachlorideinduced
hepatic damage
rats. Asian
Pac J Trop
Med 2012;5(4):289-93.
2. Rajesh MG, Latha MS. Preliminary evaluation of the antihepatotoxic
activity of Kamilari, a polyherbal formulation. J Ethnopharmacol
3. Mohamed Saleem TS, Chetty M, Ramkanth S, Rajan VS, Mahesh KK,
Gauthaman K. Hepatoprotective herbs – A review. Int J Res Pharm Sci
4. Nwaehujor CO, Udeh NE. Screening of ethyl acetate extract of Bridelia
micrantha for hepatoprotective and anti-oxidant activities on Wistar
rats. Asian Pac J Trop Med 2011;4(10):796-8.
5. Vermeulen NP, Bessems JG, Van de Straat R. Molecular aspects
of paracetamol-induced hepatotoxicity and its mechanism-based
prevention. Drug Metab Rev 1992;24(3):367-407.
6. Cohen SD, Khairallah EA. Selective protein arylation and
acetaminophen-induced hepatotoxicity. Drug Metab Rev
7. Parmar SR, Patel HV, Kalia K. Hepatoprotective activity of some plants
extract against paracetamol induced hepatotoxicity in rats. J Herb Med
Toxicol 2010;4(2):101-6.
8. Lynch T, Price A. The effect of cytochrome P450 metabolism on
drug response, interactions, and adverse effects. Am Fam Physician
9. Blazka ME, Wilmer JL, Holladay SD, Wilson RE, Luster MI. Role of
proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol
Appl Pharmacol 1995;133(1):43-52.
10. Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB.
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
J Pharmacol Exp Ther 1973;187(1):185-94.
11. Shah VN, Deval K. Hepatoprotective activity of leaves of Parkinsonia
aculeata linn against paracetamol induced hepatotoxicity in rats. Int J
Pharm 2011;1(2):59-66.
12. Bourdi M, Masubuchi Y, Reilly TP. Protection against acetaminopheninduced
interleukin 10,
oxide synthase. J
13. Rubinstein D, Roska AK, Lipsky PE. Liver sinusoidal lining cells express
class II major histocompatibility antigens but are poor stimulators of
fresh allogeneic T lymphocytes. J Immunol 1986;137(6):1803-10.
14. Handa SS, Sharma A, Chakraborti KK. Natural products and plants as
liver protecting drugs. Fitoterapia 1989;57:307-51.
15. Kirtikar KR, Basu BD. Indian Medicinal Plants. Vol. 3. New Delhi:
International Book Distributors; 2005. p. 340-5.
16. Jafri MA, Jalis Subhani M, Javed K, Singh S. Hepatoprotective activity
of leaves of Cassia occidentalis against paracetamol and ethyl alcohol
intoxication in rats. J Ethnopharmacol 1999;66(3):355-61.
17. Trease GE, Evans WC. Pharmacognosy. Vol. 10. New Delhi: Elsevier
Publishers; 2007. p. 414-8.
18. Stickel F, Schuppan D. Herbal medicine in the treatment of liver
diseases. Dig Liver Dis 2007;39(4):293-304.
19. Kuran JC. Plants that heal, Owners Oriental Watchman Publishing
House, Pune, 1995, 217-219.
20. Nirmala M, Girija K, Lakshman K, Divya T. Hepatoprotective activity
of Musa paradisiaca on experimental animal models. Asian Pac J Trop
Biomed 2012;2(1):11-5.
21. Akilavalli N, Radhika J, Brindha P. Hepatoprotective activity of
Ocimum sanctum linn. against lead induced toxicity in albino rats.
Asian J Pharm Clin Res 2011;4(2):84-7.
22. Chattopadhyay RR, Sarkar SK, Ganguly S, Medda C, Basu TK.
Hepatoprotective activity of Ocimum sanctum leaf extract against
paracetamol induced hepatic damage in rats. Indian J Pharmacol
23. Bhakta T, Banerjee S, Mandal SC, Maity TK, Saha BP, Pal M.
Hepatoprotective activity of Cassia fistula leaf extract. Phytomedicine
24. Ajayi GO, Adeniyi TT, Babayemi DO. Hepatoprotective and some
haematological effects of Allium sativum and Vitamin C in leadexposed
wistar rats. Int J Med Sci 2009;1:64-7.
25. Takate SB, Pokharkar RD, Chopade VV, Gite VN. Hepatoprotective
activity of the ethyl acetate extract of Launaea intybacea (jacq) beauv
in paracetamol induced hepato-toxicity in albino rats. Int J Pharm Sci
Rev Res 2010;1(2):72-4.
26. Chattopadhyay RR, Bandyopadhyay M. Possible mechanism of
hepatoprotective activity of Azadirachta indica leaf extract against
paracetamol induced hepatic damage in rats. Indian J Pharmacol
27. Somchit MN, Sulaiman MR, Noratunlina R, Ahmad Z. Hepatoprotective
effects of Curcuma longa rhizomes in paracetamol induced liver
damage in rats. Vol. 1. Proceedings of the Regional Symposium on
Environment and Natural Resources Kuala Lumpur, Malaysia. 2002.
p. 698-702.
28. Kiso Y, Suzuki Y, Watanabe N, Oshima Y, Hikino H. Antihepatotoxic
principles of Curcuma longa rhizomes. Planta Med 1983;49(3):185-7.
29. Das S. Hepatoprotective activity of methanol extract of fenugreek seeds
on rats. IJPSR 2014;5(4):1506-13.
440 Views | 1161 Downloads
How to Cite
Chaudhary, P., S. Ahmad, and N. Ali Khan. “HERBAL PLANTS - A BOON FOR HEPATOTOXICITY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 37-40, https://innovareacademics.in/journals/index.php/ajpcr/article/view/8737.
Review Article(s)