• Swaraj Bandhu Kesh Department of Physiology, Government Medical College Rajnandgaon, Rajnandgaon, Chhattisgarh 491441.
  • Debashree Sarkar Department of Physiology, PT. JNM Medical College & Hospital, Raipur, Chhattisgarh, India.
  • Krishnendu Manna Department of Physiology, University College of Science & Technology, 92, APC Road, Kolkata-700009, West Bengal, India.


Environmental factors such as high saturated fat content in a diet affect pro- and antioxidative balances in metabolic tissues. High-dietary fat intake
promotes the development of obesity and metabolic disorders in humans and rodents as a result of disproportion between energy intake and energy
expenditure. The dreaded events of high-fat diet (HFD) are obesity, hypertension, cardiovascular and cerebrovascular anarchy, Type II diabetes,
infertility, and even cancer. HFD - induced systemic oxidative stress insults an imbalance between oxidants derivatives production and antioxidants
defenses. Reactive oxygen species are mostly reasoned to be detrimental for health. Many evidences regarding HFD - elicited oxidative stress gathered
over the past few years based on established correlations of biomarkers or end-products of free-radical-mediated oxidative stress. The hypothesis
that oxidative stress plays a prodigious role in the development of metabolic disorders, especially insulin resistance, hyperlipidemia, cardiovascular
disease or hepatic steatosis, and steatohepatitis. In this review, we elucidated the mechanistic links between HFD - induced oxidative stress and its
impact on metabolic complications development.
Keywords: Adenosine monophosphate-activated protein kinase, Complications, High-fat diet, Metabolic syndrome, Oxidative stress.


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Author Biographies

Swaraj Bandhu Kesh, Department of Physiology, Government Medical College Rajnandgaon, Rajnandgaon, Chhattisgarh 491441.

Assistant Professor

Department of Physiology

Debashree Sarkar, Department of Physiology, PT. JNM Medical College & Hospital, Raipur, Chhattisgarh, India.

Professor and Head, Department of Physiology

Krishnendu Manna, Department of Physiology, University College of Science & Technology, 92, APC Road, Kolkata-700009, West Bengal, India.

Senior Research Fellow, Department of Physiology


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How to Cite

Kesh, S. B., D. Sarkar, and K. Manna. “HIGH-FAT DIET-INDUCED OXIDATIVE STRESS AND ITS IMPACT ON METABOLIC SYNDROME: A REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 1, Jan. 2016, pp. 47-52, https://innovareacademics.in/journals/index.php/ajpcr/article/view/8915.



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