• Swaraj Bandhu Kesh Department of Physiology, Government Medical College Rajnandgaon, Rajnandgaon, Chhattisgarh 491441.
  • Debashree Sarkar Department of Physiology, PT. JNM Medical College & Hospital, Raipur, Chhattisgarh, India.
  • Krishnendu Manna Department of Physiology, University College of Science & Technology, 92, APC Road, Kolkata-700009, West Bengal, India.


Environmental factors such as high saturated fat content in a diet affect pro- and antioxidative balances in metabolic tissues. High-dietary fat intake
promotes the development of obesity and metabolic disorders in humans and rodents as a result of disproportion between energy intake and energy
expenditure. The dreaded events of high-fat diet (HFD) are obesity, hypertension, cardiovascular and cerebrovascular anarchy, Type II diabetes,
infertility, and even cancer. HFD - induced systemic oxidative stress insults an imbalance between oxidants derivatives production and antioxidants
defenses. Reactive oxygen species are mostly reasoned to be detrimental for health. Many evidences regarding HFD - elicited oxidative stress gathered
over the past few years based on established correlations of biomarkers or end-products of free-radical-mediated oxidative stress. The hypothesis
that oxidative stress plays a prodigious role in the development of metabolic disorders, especially insulin resistance, hyperlipidemia, cardiovascular
disease or hepatic steatosis, and steatohepatitis. In this review, we elucidated the mechanistic links between HFD - induced oxidative stress and its
impact on metabolic complications development.
Keywords: Adenosine monophosphate-activated protein kinase, Complications, High-fat diet, Metabolic syndrome, Oxidative stress.

Author Biographies

Swaraj Bandhu Kesh, Department of Physiology, Government Medical College Rajnandgaon, Rajnandgaon, Chhattisgarh 491441.

Assistant Professor

Department of Physiology

Debashree Sarkar, Department of Physiology, PT. JNM Medical College & Hospital, Raipur, Chhattisgarh, India.
Professor and Head, Department of Physiology
Krishnendu Manna, Department of Physiology, University College of Science & Technology, 92, APC Road, Kolkata-700009, West Bengal, India.
Senior Research Fellow, Department of Physiology


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How to Cite
Kesh, S. B., D. Sarkar, and K. Manna. “HIGH-FAT DIET-INDUCED OXIDATIVE STRESS AND ITS IMPACT ON METABOLIC SYNDROME: A REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 47-52, https://innovareacademics.in/journals/index.php/ajpcr/article/view/8915.
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