HYPOGLYCEMIC AND ANTIHYPERLIPIDEMIC EFFECTS OF ADIANTUM CAUDATUM IN ALLOXAN INDUCED DIABETES IN RATS

  • Dipankar Saha GIPS
  • Surajit Kumar Ghosh GIPS
  • Trishna Das
  • Shanti Bhushan Mishra

Abstract

ABSTRACT
Objective: To investigate the hypoglycemic and antihyperlipidemic effect of a successive ethanolic extract of Adiantum caudatum (EEAC) whole plant
in alloxan induced diabetic rats.
Methods: Diabetes was induced in Wistar albino rats by the administration of alloxan (140 mg/kg b. w., i.p.). EEAC (200 mg/kg b. w., p.o.) was
administered to diabetic rats for 21 days in alloxan induced diabetic rats. The effect of EEAC on blood glucose and body weight was studied in alloxan
induced diabetic rats. All these effects were compared with glibenclamide (10 mg/kg b. w., p.o.) as a reference antidiabetic drug.
Results: The administration of EEAC (200 mg/kg b. w., p.o.) resulted in a significant decrease in blood glucose level and a significant increase in body
weight in alloxan induced diabetic rats. Furthermore, EEAC showed antihyperlipidemic activity as evidenced by a significant decrease in serum total
cholesterol and triglyceride levels in alloxan induced diabetic rats.
Conclusion: The results suggest that the EEAC possess a promising hypoglycemic effect in alloxan induced diabetic rats.
Keywords: Hypoglycemic, Antihyperlipidemic, Adiantum caudatum, Alloxan, Diabetes.

References

1. Atkinson MA, Maclaren NK. The pathogenesis of insulin‑dependent
diabetes mellitus. N Engl J Med 1994;331(21):1428‑36.
2. Pillai M. Reader’s Digest. Could you be a Diabetic. New Delhi: Living
Media India Limited Press; 2006. p. 138.
3. Venkatesh S, Thilagavathi J, Shyam Sundar D. Anti‑diabetic activity of
flowers of Hibiscus rosasinensis. Fitoterapia 2008;79(2):79‑81.
4. Tsuzuki K, Ohashi A, Arai Y, Masuda K, Takano A, Shiojima K, et al.
Terpenoids from Adiantum caudatum. Phytochemistry 2001;58(2):363‑7.
5. Muraleedharan N, Jalajakumari M, Johnson M, Mony M, Zachariah M,
Solomon J. Inter‑specific variation studies on the phyto‑constituents of
Christella and Adiantum using phytochemical methods. Asian Pac J
Trop Biomed 2012;2:S40‑5.
6. Kokate CK. Preliminary Phytochemical Screening, Practical
Pharmacognosy. 1
ed. New Delhi: Vallabh Prakashan; 1986. p. 111.
7. OECD. Organization of Economic Co‑operation and Development. In:
st
Acute Oral Toxicity Guidelines 420. Paris: OECD; 2001. p. 12‑4.
8. Joy KL, Kuttan R. Anti‑diabetic activity of Picrorrhiza kurroa extract.
J Ethnopharmacol 1999;67(2):143‑8.
9. Vogel GH, Gang W. Drug discovery and evaluation pharmacological
assay. In: Methods to Induce Experimental Diabetes Mellitus.
Heidelberg: Springer Verlag; 2002. p. 950.
10. Fossati P, Prencipe L. Serum triglycerides determined colorimetrically
with an enzyme that produces hydrogen peroxide. Clin Chem
1982;28(10):2077‑80.
11. Rao BK, Kesavulu MM, Giri R, Appa Rao C. Antidiabetic and
hypolipidemic effects of Momordica cymbalaria Hook. Fruit powder in
alloxan‑diabetic rats. J Ethnopharmacol 1999;67:103‑9.
12. Oh WK, Lee CH, Lee MS, Bae EY, Sohn CB, Oh H, et al. Antidiabetic
effects of extracts from Psidium guajava. J Ethnopharmacol
2005;96(3):411‑5.
13. Kumar R, Patel DK, Prasad SK, Laloo D, Krishnamurthy S,
Hemalatha S. Type 2 antidiabetic activity of bergenin from the roots of
Caesalpinia digyna Rottler. Fitoterapia 2012;83(2):395‑401.
Statistics
206 Views | 577 Downloads
How to Cite
Saha, D., S. Kumar Ghosh, T. Das, and S. B. Mishra. “HYPOGLYCEMIC AND ANTIHYPERLIPIDEMIC EFFECTS OF ADIANTUM CAUDATUM IN ALLOXAN INDUCED DIABETES IN RATS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 361-3, https://innovareacademics.in/journals/index.php/ajpcr/article/view/8974.
Section
Original Article(s)