• Anupam Roy


Orally disintegrating tablets (ODTs) are solid dosage forms containing drugs that disintegrate in the oral cavity within less than 1 minute leaving
an easy-to-swallow residue. The European Pharmacopeia adopted the term orodispersible tablet for a tablet that disperses or disintegrates within
<3 minutes in the mouth before swallowing. ODT is a good choice of drug delivery for pediatric and geriatric patients because it troubleshoots the
problem of dysphagia. The current article is focused on ideal characteristics, advantages and disadvantages, various technologies developed for ODT,
evaluation methods along with recent research and future potential.
Keywords: Orodispersible tablets, Mechanism of disintegration, Fast dissolving films, Recent research.


1. Debjit B, Chiranjib B, Krishna K, Chandira RM. Fast dissolving tablet:
An overview. J Chem Pharm Res 2009;1(1):163-77.
2. Sastry VS, Ram NJ, Joseph AF. Recent technological advances in oral
drug delivery – A review. PSTT 2000;3:139-44.
3. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating
tablets: Developments, technologies, taste-masking and clinical studies.
Crit Rev Ther Drug Carrier Syst 2004;21(6):433-76.
4. Sreenivas SA, Dandagi PM, Gadad AP, Godbloe AM, Hiremath SP,
Mastiholimath VS. Orodispersible tablets: New-fangled drug delivery
systems – A review. Indian J Pharm Educ Res 2005;39(4):177-81.
5. Seager H. Drug-delivery products and the Zydis fast-dissolving dosage
form. J Pharm Pharmacol 1998;50(4):375-82.
6. Bradoo R, Shahani S, Deewan B, Sudarshan S. Fast dissolving drug
delivery system. J Am Med Assoc India 2001;4(10):27-31.
7. Bangale GS, Shinde GV, Stephen Rathinaraj B. New generation of
orodispersible tablets: Recent advances and future propects. Int J Adv
Pharm Sci 2011;2:17-28.
8. Brown D. Orally disintegrating tablets - Taste over speed. Drug Deliv
Technol 2003;3:58-61.
9. Chiman B, Isha S. Development of fast disintegration tablets as oral drug
delivery system - A review. Indian J Pharm Biol Res 2013;1(3):80-99.
10. Gupta A, Mishra AK, Gupta V, Bansal P, Singh R, Singh AK. Recent
trends of fast dissolving tablet - An overview of formulation technology.
Int J Pharm Biol Arch 2010;1(1):1-10.
11. Ashish P, Harsoliya MS, Pathan JK, Shruti S. A review- Formulation of
mouth dissolving tablet. Int J Pharm Clin Sci 2011;1(1):1-8.
12. Prateek S, Ramdayal G, Kumar SU, Ashwani C, Ashwini G, Mansi S.
Fast dissolving tablets: A new venture in drug delivery. Am J PharmTech
Res 2012;2(4):252-79.
13. Deshpande KB, Ganesh NS. Orodispersible tablets: An overview of
formulation and technology. Int J Pharm Biol Sci 2011;2(1):726-34.
Asian J Pharm Clin Res, Vol 9, Issue 1, 2016, 19-26
14. Kumar E, Bhagyashree J. Mouth dissolving tablets – A comprehensive
review. Int J Pharm Res Rev 2013;2(7):25-41.
15. Rakesh P, Mona P, Prabodh SC, Dhirender K, Sanju N. Orally
disintegrating tablets - Friendly to pediatrics and geriatrics. Arch Appl
Sci Res 2010;2(2):35-48.
16. Patil MR, Gujarathi Nayan A, Rane Bhushan R. Formulation and
evaluation of mouth dissolving tablet: Review article. Pharm Sci Monit
17. Deepak H, Geeta A, Hari Kumar SL. Recent trends of fast dissolving
drug delivery system - An overview of formulation technology.
Pharmacophore 2013;4(1):1-9.
18. Velmurugan S, Vinushitha S. Oral disintegrating tablets: An overview.
Int J Chem Pharm Sci 2010;1(2):1-12.
19. Kumar NP, Nayyar P, Kumar SP. Fast dissolving tablets - A review.
Middle East J Sci Res 2015;23(1):142-8.
20. Sagar N, Goswami L, Kothiyal P. Orally disintegrating tablets:
A review. Int J Adv Pharm Res 2012;3(10):1222-8.
21. Badgujar BP, Mundada AS. The technologies used for developing
orally disintegrating tablets: A review. Acta Pharm 2011;61(2):117-39.
22. Sanket K, Garg SK, Ajay A, Pradeep L. Fast dissolving tablets (FDTS):
Recent trends and new market opportunities. Indo Am J Pharm Res
23. Patil PB, More VN, Tour NS. Recent trends in orodispersible tablets
– An overview of formulation technology and future prospects. Int J
Pharm Sci Res 2015;6(7):1056-66.
24. Pooja A, Arora SV. Orodispersible tablets: A comprehensive review. Int
J Res Dev Pharm Life Sci 2013;2(2):270-84.
25. Chandra NB, Bhaskar M, Kadambari P, Nidhi S, Swati J, Stuti S, et al.
An overview on fast dissolving drug delivery system. Asian J Pharm
Sci Res 2011;1(2):1-30.
26. Mohit M, Sunil T, Manish G, Pankaj G. Super disintegrants: An updated
review. Int J Pharm Pharm Sci Res 2012;2(2):26-35.
27. Khairnar Dhiraj A, Anantwar Sanjay P, Chaudhari Chetan S,
Shelke Pravin A. Super disintegrants: An emerging paradigm in
orodispersible tablets. Int J Biopharm 2014;5(2):119-28.
28. Kumar SS, Ravendra V, Vikash C, Prakash SS. Orally disintegrating
tablets: A dosage form that extends the market exclusivity and patent
protection. World J Pharm Pharm Sci 2014;3(7):526-46.
29. Shubhra S, Kumar YS. Fast dissolving tablets: A strategy to
improve solubility of poorly soluble compounds. Glob J Pharmacol
30. Puneet M, Kumar SP, Rishabha M. A review on recent advances of oral
mouth dissolving tablet. J Drug Discov Ther 2014;2(18):17-22.
31. Alam MD, Nayyar P, Kumar SP. Novel technology for formulation
and evaluation of mouth dissolving tablet - A review. Adv Biol Res
32. Deepika J, Mishra A. A review - Formulation and development of
orodispersible tablet. Int J Pharm Erudition 2014;4(1):21-38.
33. Dey P, Maiti S. Orodispersible tablets: A new trend in drug delivery.
J Nat Sci Biol Med 2010;1(1):2-5.
34. Reddy BV, Navaneetha K. Formulation and evaluation of orodispersible
tablets of candesartan. Pharm Innov J 2015;4(1):25-32.
35. Kumar VS, Karthik N. Lovastatin fast dissolving tablets: Formulation
and in vitro evaluation. Appl Sci Rep 2015;11(2):76-82.
36. Girish TK, Shalini M. Formulation and evaluation of taste masked
orodispersible tablet of levocetirizine dihydrochloride. Bull Pharm Res
37. Pankaj S, Ashish D, Dheerendra R, Yogendra R, Ramakant J, Kuldeep S.
Formulate and evaluate orodispersible tablets of primaquine. Indo Am J
Pharm Res 2015;5(5):1625-32.
38. Prasad SR, Nagamani R, Satyajit P. Formulation, in vitro characterization
and stability studies of fast dispersing tablets of diclofenac sodium. J
Appl Pharm Sci 2015;5(7):94-102.
39. Reshma J, Gangotri Y, Vaishali J, Ashish J. Formulation and evaluation
of triphala orodispersible tablet. Int J Pharm Life Sci 2015;6(5):4491-4.
40. Srinivasan R, Vinod KK, Lakshmana G, Rajesh KD, Savinay KK.
Mouth dissolving tablets of meclizine hydrochloride by using super
disintegrants formulation and in-vitro evaluation. Int J Chem Pharm Sci
41. Kalyankar P, Panzade P, Lahoti S. Formulation design and optimization
of orodispersible tablets of quetiapine fumarate by sublimation method.
Indian J Pharm Sci 2015;77(3):267-73.
42. Pinkal P, Jitendra P. Formulation development and evaluation of fast
dissolving tablets of cyproheptadine hydrochloride. Pharm Sci Monit
2014;5 Suppl 1:247-55.
43. Dhadwe AK, Rathod CP, Vadvalkar SM, Ghiware NB, Gond NY,
Shendarkar GR, et al. Formulation and evaluation of orodispersible
tablet of cinnarizine by direct compression method. World J Pharm
Pharm Sci 2014;3(5):588-610.
44. Ayyappan T, Poojitha C, Vetrichelvan T. Formulation design,
optimization and in vitro evaluation of novel orodissolving
tablets of efavirenz for HIV infections. Bangladesh J Sci Ind Res
45. Tanmoy G, Amitava G, Devi P. A review on new generation
orodispersible tablets and its future prospective. Int J Pharm Pharm Sci
1222 Views | 8253 Downloads
How to Cite
Roy, A. “ORODISPERSIBLE TABLETS: A REVIEW”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 19-26, https://innovareacademics.in/journals/index.php/ajpcr/article/view/9029.
Review Article(s)